Interleukin-17 concentration as a biomarker in diagnosis of exudative pleural effusion compared with benign pleural effusion

Abstract

Pleural effusion is one of signs and complications resulting from malignant disease such as lung and breast cancer, and also tuberculosis and infective lung disease by cytological analysis of pleural fl uid we can use of tumor marker and other biomarkers to better diagnose malignant pleural effusion.in this study we examined the concentration of interleukin-17 in pleural fl uid with causes of exudative pleural effusion in the patients referred to hospital of 2015-2016.This is a descriptiveanalytical and case-control study and 130 patients with exudative pleural effusion were enrolled in the study after an informed consent samples collected from the patients divide into two main group including 88 patients with malignant pleural effusion and 42 patient with benign effusion. in the next step by using of the same previous pleural fl uid samples, the concentration of interleukin-17 was measured with ELISA by specifi c kit after entering to computer through SPSS-18 statistical software, description of data was done into frequency and percentage.Interleukin-17 concentration was (69.73±64.58) in patients with malignant causes and (55.32±43.60) in benign causes.The results showed that this different was statistically signifi cant (P=0.02) and interleukin-17 rate, is higher in the malignant pleural effusion.According to higher levels of interleukin-17 in malignant pleural effusion maybe we can achieve important result in differentiating between malignant and non-malignant pleural exudate, without the need for invasive procedures, by putting together the clinical symptoms, the interleukin-17 concentration in pleural fl uid and pleural fl uid cytology results.