Interleukin 17, Interleukin 22 and FoxP3 expression in tissue and serum of non-segmental vitiligo: A case- controlled study on eighty-four patients

El-Ela, Mostafa Abou; Hegazy, Rehab A.; Fawzy, Marwa M.; Rashed, Lalia A.; Rasheed, Hoda

doi:10.1684/ejd.2013.2023

Cited by 77 publications

(72 citation statements)

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“…Corticosteroids, immunomodulators (tacrolimus, pimecrolimus), methotrexate and cyclosporin all decrease IL-1b production and have been tried with variable success in vitiligo [53][54][55][56][57]. Immunohistochemical studies showed infiltration of Th17 cells in vitiligo skin samples [58], and both serum and lesional expression of IL17 are increased in vitiligo [21]. That IFN-c inhibiting melanogenesis and inducing apoptosis in melanocytes reveals a pivotal role of CD8 + cytotoxic T lymphocytes in vitiligo [59].…”

Section: Discussionmentioning

confidence: 99%

Interleukin 10 protects primary melanocyte by activation of Stat-3 and PI3K/Akt/NF-κB signaling pathways

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Interleukin 10 protects primary melanocyte by activation of Stat-3 and PI3K/Akt/NF-κB signaling pathways

et al. 2016

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“…Vitiligo subjects were noted to have nearly 2-fold higher serum IL-17 compared to controls (p<0.001) that positively correlated with both Vitiligo Area Scoring Index (VASI) and Vitiligo Disease Activity (VDA)[55]. …”

Section: Il-17 Dynamics In Vitiligomentioning

confidence: 99%

“…Lesional expression of IL-17 mRNA in NSV has been reported to be up to 7-fold higher, with perilesional expression 3-fold higher compared to non-lesional control skin[52,55,63]. The extent of body surface affected by vitiligo (r=0.48, p<0.05), disease duration (r=0.45, p<0.015), and serum IL-17 (r=0.54, p=0.002) have also been noted to positively correlate with tissue IL-17 expression[52].…”

Section: Il-17 Dynamics In Vitiligomentioning

confidence: 99%

The role of IL-17 in vitiligo: A review

Singh

Lee

Vujkovic-Cvijin

et al. 2016

Autoimmunity Reviews

116

101

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IL-17 is involved in the pathogenesis of several autoimmune diseases, however its role in vitiligo has not been well defined. Emerging human and mouse studies have demonstrated that systemic, tissue, and cellular levels of IL-17 are elevated in vitiligo. Many studies have also shown significant positive correlations between these levels and disease activity, extent, and severity. Treatments that improve vitiligo, such as ultraviolet B phototherapy, also modulate IL-17 levels. This review synthesizes our current understanding of how IL-17 may influence the pathogenesis of autoimmune vitiligo at the molecular level. This has implications for defining new vitiligo biomarkers and treatments.

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“…Th17 cells have been implicated in skin lesions in vitiligo [110] because of the discovery of higher levels of serum IL-17 in patients than controls [111, 112]. Th17 cell infiltration and decreased Tregs have also been reported [113].…”

Section: Th17 Cells In Autoimmune and Infectious Diseasesmentioning

confidence: 99%

Th17 Cells in Autoimmune and Infectious Diseases

Zambrano‐Zaragoza

Romo-Martínez

Durán‐Avelar

et al. 2014

International Journal of Inflammation

152

125

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The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review.

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Interleukin 17, Interleukin 22 and FoxP3 expression in tissue and serum of non-segmental vitiligo: A case- controlled study on eighty-four patients

Cited by 77 publications

References 0 publications

Interleukin 10 protects primary melanocyte by activation of Stat-3 and PI3K/Akt/NF-κB signaling pathways

Interleukin 10 protects primary melanocyte by activation of Stat-3 and PI3K/Akt/NF-κB signaling pathways

The role of IL-17 in vitiligo: A review

Th17 Cells in Autoimmune and Infectious Diseases

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