Interleukin 17A as a good predictor of the severity of Mycoplasma pneumoniae pneumonia in children

Yang, Mengxuan; Meng, Fanzheng; Kuo, Way; Gao, Man; Lu, Ruipeng; Li, Mengyao; Zhao, Fangxing; Huang, Lijuan; Zhang, Yining; Cheng, Genhong; Wang, Xiaosong

doi:10.1038/s41598-017-13292-5

Cited by 40 publications

(53 citation statements)

References 57 publications

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“…Furthermore, we found that more atopic children developed severe MP pneumonia. This finding was in accordance with the results in recent reports, which showed that a decreased IL‐17 level is a valuable biomarker in severe MP pneumonia children …”

Section: Discussionmentioning

confidence: 88%

“…This finding was in accordance with the results in recent reports, which showed TA B L E 4 Clinical characteristics, atopy, and specific allergen sensitization in patients with extrapulmonary and those with pulmonary that a decreased IL-17 level is a valuable biomarker in severe MP pneumonia children. 22 In addition, the serum IL-17 levels were also significantly lower in the extrapulmonary group than in the pulmonary group, which may indicate that the immunoregulatory function of IL-17 is insufficient in these children. These findings partly explain the recent report that more children in a high-MP-load group than those in a low-MP-load group presented with extrapulmonary manifestations and atopic conditions.…”

Section: Ta B L E 2 Comparison Of Respiratory Severity Between Atopicmentioning

confidence: 87%

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Impact of atopy on the severity and extrapulmonary manifestations of childhood Mycoplasmapneumoniae pneumonia

Wang

Sun

Liu

et al. 2019

Clinical Laboratory Analysis

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Objectives The impact of atopy on disease severity and extrapulmonary manifestations in children with Mycoplasma pneumoniae (MP) pneumonia is unknown. Methods Patients diagnosed with MP pneumonia between January 2016, and December 2017, were enrolled in this study. A total of 150 MP pneumonia patients were enrolled at diagnosis and divided into the atopic group (n = 48) and the nonatopic group (n = 102). Furthermore, these patients were also assessed after being divided into the pulmonary group (n = 120) and the extrapulmonary group (n = 30). Clinical characteristics, respiratory disease severity, any allergy history, and specific allergen sensitizations were collected from all patients. The serum interleukin‐17 (IL‐17) and total immunoglobulin E (lgE) levels were also measured. Results More children in the atopic group than those in the nonatopic group presented with severe MP pneumonia, tachypnea, oxygen therapy, steroid treatment, atopic conditions including asthma attack, a previous history of asthma, decreased IL‐17 levels, and increased IgE levels (all P < 0.05). When compared with those in the pulmonary group, the patients in the extrapulmonary group showed higher percentages of atopy, higher total lgE levels, and lower IL‐17 levels (all P < 0.05). Conclusions Atopy may be a risk factor for disease severity and extrapulmonary manifestations in children with MP pneumonia.

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Section: Discussionmentioning

confidence: 88%

Section: Ta B L E 2 Comparison Of Respiratory Severity Between Atopicmentioning

confidence: 87%

Impact of atopy on the severity and extrapulmonary manifestations of childhood Mycoplasmapneumoniae pneumonia

Wang

Sun

Liu

et al. 2019

Clinical Laboratory Analysis

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“…Although the mechanism of RMPP is not clear, it is widely accepted that inflammatory reactions and immune responses may play an important role in the progress of RMPP. Biomarkers related to inflammatory reactions were evaluated by previous studies 8–12 . CRP, LDH, and IL‐6 were found to be associated with high risk of RMPP in children through an ordinal logistic regression procedure 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Biomarkers related to inflammatory reactions were evaluated by previous studies. [8][9][10][11][12] CRP, LDH, and IL-6 were found to be associated with high risk of RMPP in children through an ordinal logistic regression procedure. 8 Other factors of clinical symptoms and radiological examinations were also found to be associated with RMPP.…”

Section: Rmpp Usually Leads To Long-duration Fever and May Develop Intomentioning

confidence: 99%

“…In recent years, some studies were conducted to explore the independent predictors of RMPP from laboratory and radiological data. Current studies showed that the level of C‐reactive protein (CRP), lactate dehydrogenase (LDH), T‐lymphocyte subsets, cytokines including interleukin‐10 (IL‐10) and interferon‐gamma (IFN‐γ) might be nonspecific factors to predict RMPP 8–12 . Though the main results in previous studies might improve the awareness of physicians about RMPP, there were still some limitations.…”

Section: Introductionmentioning

confidence: 99%

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Development and validation of a simple‐to‐use nomogram for predicting refractoryMycoplasma pneumoniaepneumonia in children

Cheng

Lin

Zheng

et al. 2020

Pediatric Pulmonology

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Objective This study aimed to develop and validate a simple‐to‐use nomogram for predicting refractory Mycoplasma pneumoniae pneumonia (RMPP) in children. Methods A total of 73 children with RMPP and 146 children with general Mycoplasma pneumoniae pneumonia were included. Clinical, laboratory, and radiological data were obtained. A least absolute shrinkage and selection operator (LASSO) regression model was used to determine optimal predictors. The nomogram was plotted by multivariable logistic regression. The performance of the nomogram was assessed by calibration, discrimination, and clinical utility. Results The LASSO regression analysis identified lactate dehydrogenase, albumin, neutrophil ratio, and high fever as significant predictors of RMPP. This nomogram‐illustrated model showed good discrimination, calibration, and clinical value. The area under the receiver operating characteristic curve of the nomogram was 0.884 (95% CI, 0.823‐0.945) in the training set and 0.881 (95% CI, 0.807‐0.955) in the validating set. Calibration curve and Hosmer‐Lemeshow test showed good consistency between the predictions of the nomogram and the actual observations, and decision curve analysis showed that the nomogram was clinically useful. Conclusion A simple‐to‐use nomogram for predicting RMPP in early stage was developed and validated. This may help physicians recognize RMPP earlier.

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Analysis of cytokine levels, cytological findings, and MP‐DNA level in bronchoalveolar lavage fluid of children with Mycoplasma pneumoniae pneumonia

Deng

Liang

et al. 2023

Immunity Inflam & Disease

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Background The present study was conducted to determine the inflammatory response in the lungs of children with Mycoplasma pneumoniae pneumonia (MPP). Methods This study retrospectively analyzed cytokine levels, cytological findings, and M. pneumoniae (MP)‐DNA level in the bronchoalveolar lavage fluid (BALF) of 96 children with MPP. The study utilized Spearman's correlation method to evaluate the contribution of BALF and blood parameters in MPP children. Results (1) A total of 96 MPP children were classified into the Low MP‐DNA MPP group (BALF MP‐DNA ≤ 10 5 copies/mL) and the High MP‐DNA MPP group (BALF MP‐DNA > 10 5 copies/mL); the Non‐fever MPP group (no fever during the entire course of pneumonia) and the Fever MPP group; the Defervescence MPP group (fever had subsided at the time of bronchoscopy) and the Fervescence MPP group; and the Mild MPP group and the Severe MPP group. (2) The High MP‐DNA MPP, Fever MPP, Fervescence MPP, and Severe MPP groups had higher levels of interleukin (IL)‐6, IL‐10, and tumor necrosis factor‐α (TNF‐α) in their BALF (all p < .05). (3) The proportions of neutrophils and macrophages in the BALF of the High MP‐DNA MPP and Fever MPP groups increased and decreased, respectively (all p < .05). (4) In the BALF of MPP children, MP‐DNA, IL‐6, IL‐10, TNF‐α, and interferon gamma (IFN‐γ) levels positively correlated with neutrophil proportion while negatively correlated with macrophage proportion (all p < .05). (5) The MP‐DNA, IL‐6, IL‐10, TNF‐α, and IFN‐γ levels in the BALF of MPP children were positively correlated with the levels of C‐reactive protein, procalcitonin, lactic dehydrogenase, fibrinogen, and d‐dimer, while they were negatively correlated with the albumin level (all p < .05). Conclusions In children with MPP, the pulmonary inflammatory immune response was stronger in the High MP‐DNA MPP, Fever MPP, Fervescence MPP, and Severe MPP groups. The relationship between pulmonary cytokine levels, MP‐DNA load, and serum inflammatory parameters were found to be weak.

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Interleukin 17A as a good predictor of the severity of Mycoplasma pneumoniae pneumonia in children

Cited by 40 publications

References 57 publications

Impact of atopy on the severity and extrapulmonary manifestations of childhood Mycoplasmapneumoniae pneumonia

Impact of atopy on the severity and extrapulmonary manifestations of childhood Mycoplasmapneumoniae pneumonia

Development and validation of a simple‐to‐use nomogram for predicting refractoryMycoplasma pneumoniaepneumonia in children

Analysis of cytokine levels, cytological findings, and MP‐DNA level in bronchoalveolar lavage fluid of children with Mycoplasma pneumoniae pneumonia

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