Interleukin‐17A gene polymorphism with the susceptibility of intestinal symptoms in patients with Behçet's disease

Nakamura, Koichiro; Miyano, Kyohei; Tsuchida, Takaaki; Meguro, Akira; Mizuki, Nobuhisa

doi:10.1111/1346-8138.13251

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Il-17 and Il-181

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2023

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“…The another genetic study in a Korean population, the IL17A rs8193036C > T variant was associated with the risk of intestinal BD [62]. In another study, the IL-17A gene rs2275913 polymorphism has been showed it might be associated with intestinal involvement in patients with BD [63]. IL-18 is a proinflammatory cytokine that mediates T-helper (Th)-1-polarized immune responses.…”

Section: Il-17 and Il-18mentioning

confidence: 99%

Genetics of Behçet’s Disease

Kocaaga¹

2023

Rare Diseases - Recent Advances

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Behçet’s disease (BD; MIM 109650) is an autoinflammatory disease characterized by with recurrent oral aphthae, genital ulcers and vasculitis involving the skin, joints, eyes, veins, arteries, nervous and gastrointestinal systems. Although the pathogenesis remains uncertain, genome-wide and validation studies have demonstrated that genetic predisposition is a major factor in disease susceptibility. Several gene polymorphisms that are involved in the response to pathogens and modulate inflammation have been associated with the pathophysiology of BD. Understanding the genetic association with BD may ensure insight into the pathogenesis and for development of targeted therapies for this autoinflammatory disease. This chapter will deal the role of genetic and epigenetic factors as contributing factors in the pathogenesis of BD.

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Section: Il-17 and Il-18mentioning

confidence: 99%