Interleukin-17A gene variants and risk of coronary artery disease: A large angiography-based study

Zhang, Xiaolin; Pei, Fang; Zhang, Mingxiang; Cao, Yan; Huang, Mingfang; Wang, Tao; Han, Yaling

doi:10.1016/j.cca.2010.10.027

Cited by 33 publications

(47 citation statements)

References 29 publications

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“…However, the results of the present study were not consistent with the findings of Zhang et al (10), which may be attributed to ethnic differences between the populations studied. The role of the IL17A rs3819025 polymorphism in the development of FP artery disease was also investigated and consistent with the finding of Zhang et al (10), as no association between this polymorphism and FP artery disease was observed.…”

Section: Discussioncontrasting

confidence: 99%

“…In the present study, no significant difference was observed in the genotype and allele frequencies of IL17A SNP rs8193037 between patients with FP artery disease and controls, consistent with results of a study by Vargas-Alarcón et al (33). However, the results of the present study were not consistent with the findings of Zhang et al (10), which may be attributed to ethnic differences between the populations studied. The role of the IL17A rs3819025 polymorphism in the development of FP artery disease was also investigated and consistent with the finding of Zhang et al (10), as no association between this polymorphism and FP artery disease was observed.…”

Section: Discussionsupporting

confidence: 75%

“…In addition, plasma IL17A levels were higher in patients with AMI, and the G allele was associated with increased expression of IL17A in AMI patients and was a predictive factor for CAD. The same study investigated the IL17A rs3819025 polymorphism in patients with CAD and reported no significant difference in the genotype and allele frequencies between patients with CAD and controls (10). In another study, no association was reported between rs8193037 and premature CAD; however, certain haplotypes were involved in determining the risk of developing premature CAD (33).…”

Section: Discussionmentioning

confidence: 97%

“…Zhang et al (10) reported that the incidence of IL17A rs8193037 GG homozygote and G allele was significantly higher in patients with CAD than in the general Chinese Han population. The G allele was associated with an increased risk of CAD in male patients.…”

Section: Discussionmentioning

confidence: 99%

“…IL17A has been studied as part of numerous inflammatory diseases (7,8) and has been demonstrated to serve an essential role in the maintenance of angiotensin II-induced hypertension and vascular dysfunction (9). Another study has indicated that IL17A gene variants are significantly associated with an increased risk of developing coronary artery disease (CAD) and that IL17A is overexpressed in patients with AMI (10). In a recent study, oxLDL, a hyperlipidemia stimulus, was found to upregulate IL17 receptors in human primary aortic cells (11).…”

Section: Introductionmentioning

confidence: 99%

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Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

Arslan

Bayoğlu

Tel

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Oxidized low-density lipoprotein receptor 1 (OLR1) and interleukin 17A (IL17A) have pro-inflammatory roles in the development of cardiovascular disorders. The present study evaluated the association of OLR1 and IL17A and their polymorphisms with the development of femoropopliteal (FP) artery disease. The mRNA expression of OLR1 and IL17A in peripheral blood mononuclear cells as well as the frequency of OLR1 rs11053646 and IL17A rs8193037 and rs3819025 polymorphisms were assessed by polymerase chain reaction in 70 patients with FP artery disease and 80 age-matched disease-free controls. Furthermore, the levels of plasma cytokines were assessed by multiplex immunoassay. OLR1 and IL17A mRNA expression was significantly higher in patients with FP artery disease compared with that in controls (P<0.001). No significant difference was observed in the genotypic frequencies of OLR1 rs11053646 (P= 0.87) or in IL17A rs8193037 and rs3819025 (P= 0.80 and 0.92, respectively) polymorphisms between patients with FP artery disease and controls. Plasma IL4, -6, -10, -22, -31 and -33 as well as soluble cluster of differentiation 40 ligand and tumor necrosis factor-α levels were significantly increased among FP artery disease patients compared with controls (P<0.05). Furthermore, OLR1 expression was positively correlated with triglyceride (r= 0.463, P<0.001), low-density lipoprotein cholesterol (r= 0.507, P<0.001) and total cholesterol levels (r= 0.357, P= 0.006) in patients with FP artery disease. To the best of our knowledge, the present study was the first to identify an association between OLR1 and IL17A genes and FP artery disease. OLR1 and IL17A mRNA transcripts may be associated with blood lipid parameters and with the development of FP artery disease.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

Arslan

Bayoğlu

Tel

et al. 2017

Experimental and Therapeutic Medicine

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Surface and Interface Engineering: Molybdenum Carbide–Based Nanomaterials for Electrochemical Energy Conversion

Huo

Sun

et al. 2019

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104

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Molybdenum carbide (MoxC)‐based nanomaterials have shown competitive performances for energy conversion applications based on their unique physicochemical properties. A large surface area and proper surface atomic configuration are essential to explore potentiality of MoxC in electrochemical applications. Although considerable efforts are made on the development of advanced MoxC‐based catalysts for energy conversion with high efficiency and stability, some urgent issues, such as low electronic conductivity, low catalytic efficiency, and structural instability, have to be resolved in accordance with their application environments. Surface and interface engineering have shown bright prospects to construct highly efficient MoxC‐based electrocatalysts for energy conversion including the hydrogen evolution reaction, oxygen evolution reaction, nitrogen reduction reaction, and carbon dioxide reduction reaction. In this Review, the recent progresses in terms of surface and interface engineering of MoxC‐based electrocatalytic materials are summarized, including the increased number of active sites by decreasing the particle size or introducing porous or hierarchical structures and surface modification by introducing heteroatom(s), defects, carbon materials, and others electronic conductive species. Finally, the challenges and prospects for energy conversion on MoxC‐based nanomaterials are discussed in terms of key performance parameters for the catalytic performance.

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Association of G197 Polymorphism of IL-17A Gene with Myocardial Remodeling and Aerobic Performance in Athletes

et al. 2014

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We studied the relationship between G197A polymorphism of IL-17A gene and changes in morphometric echocardiography parameters and physiological parameters in skiers (19 examinees). Genotyping was performed by restriction fragment length polymorphism analysis and echocardiography using a Nemio MX ultrasound scanner (Toshiba). Association of 197A allele of IL-17A gene with low myocardial growth and high aerobic performance of athletes was demonstrated.

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Interleukin-17A gene variants and risk of coronary artery disease: A large angiography-based study

Cited by 33 publications

References 29 publications

Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

Surface and Interface Engineering: Molybdenum Carbide–Based Nanomaterials for Electrochemical Energy Conversion

Association of G197 Polymorphism of IL-17A Gene with Myocardial Remodeling and Aerobic Performance in Athletes

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