Interleukin-17A Levels Increase in Serum of Children With Juvenile Idiopathic Arthritis

Abstract

Objectives: This study aims to determine the serum levels of interleukin-17A (IL-17A) in children with juvenile idiopathic arthritis (JIA) and analyze the correlation between IL-17A values and disease activity, certain clinical features, and laboratory markers of inflammation. Patients and methods:The study included 30 children (7 boys, 23 girls; mean age 8.8±5.3 years; range 1 to 18 years), who had been diagnosed with JIA (18 children were diagnosed during the study period and 12 children were diagnosed before the start of the study) and had active disease during the study period. Control group included 30 healthy, age-and sex-matched children (9 boys, 21 girls; mean age 8.3±4.8 years; range 1 to 18 years). The enzyme-linked immunosorbent assay was used to assess the serum IL-17A levels of children with JIA in the active phase of the disease and control group. Clinical and laboratory features of the disease were evaluated for the children with JIA. Results: Serum levels of IL-17A in children with JIA were significantly higher in comparison to control group. In children with JIA who were prospectively monitored, statistically significantly decreased IL-17A level was recorded in the inactive phase of the disease. The incidence of arthritis of coxofemoral joints was significantly more common, and the mean levels of erythrocyte sedimentation rate and C-reactive protein were significantly higher in the group of children with JIA with detectable levels of IL-17A. Children with JIA and detectable levels of IL-17A had significantly higher values of Juvenile Arthritis Disease Activity Score-27 in comparison to children with JIA and non-detectable IL-17A. Conclusion: Assessment of serum IL-17A levels in early phases of JIA gives an opportunity for early detection of children that have higher risk for worse functional outcome.

Seroprevalence of Antibodies against SARS-CoV-2 in Children with Juvenile Idiopathic Arthritis a Case-Control Study

“…In the case of JIA, treatment-naive polyarticular JIA patients were found to have enhanced responsiveness to IFN-γ stimulation compared with controls (i.e., increased STAT1 and/or STAT3 phosphorylation in subsets of CD4 T cells and classical monocytes) [ 27 ]. In addition, serum IL-17A levels are elevated in children with active JIA and decrease during the inactive phase of the disease [ 28 ]. Indeed, JIA patients with detectable levels of IL-17A have significantly higher values of JADAS 27 than those with non-detectable IL-17A [ 28 ].…”

“…In addition, serum IL-17A levels are elevated in children with active JIA and decrease during the inactive phase of the disease [ 28 ]. Indeed, JIA patients with detectable levels of IL-17A have significantly higher values of JADAS 27 than those with non-detectable IL-17A [ 28 ]. These similarities may explain the association of the immune response to the SARS-CoV-2 with JIA activity.…”

Novel biomarkers for early targeted and individualized treatment in Juvenile Idiopathic Arthritis

“…Along with the biomarkers under investigation, IL17, which has already been identified as an indicator of JIA activity, will also be determined in the collected samples. 17 Prior to inclusion in the study, an informed consent from each participant/parent will be received, according to the Helsinki Declaration.…”

Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions

“…IL-1β, IL-17, and IL-23 are all elevated at transcript and protein levels in lesional and perilesional HS skin and Th17 cells, the predominant source of IL-17 ( Kelly et al., 2015 ; Schlapbach et al., 2011 ; van der Zee et al., 2012b , 2011 ; Wolk et al., 2011 ). Within the HS lesion, IL-17 stimulates production of chemokines, cytokines, MMPs, and AMPs ( Vijatov-Djuric et al., 2017 ; Wolk et al., 2009 ). IL-1β and IL-17 may employ a positive feedback loop, as IL-17 stimulates release of IL-1β from KCs via activation of the inflammasome protein NLRP3 and caspase-1 ( Cho et al., 2012 ; Lima et al., 2016 ).…”