Interleukin-17F gene polymorphisms in Korean patients with Behçet’s disease

Abstract

IL-17 is a novel cytokine that is characterized by an ability to induce several types of cells to secrete proinflammatory cytokines in various inflammatory diseases. This study analyzed the influence of IL-17F gene polymorphisms on disease susceptibility and clinical features. Ninety-nine Behçet's disease (BD) patients and 114 controls were genotyped to analyze three single nucleotide polymorphisms (SNPs) including A126G, G155A, and A161G of the IL-17F gene using automated sequencing. We compared the frequencies of IL-17F alleles, genotypes, and haplotypes in patients with BD and controls using the chi-square or Fisher's exact test. Significant differences in the frequencies of allele and genotype in A126G SNP of IL-17 gene were found between BD patients and controls (P<0.001 and P<0.001, respectively). None of three IL-17F SNPs were associated with diverse clinical features in BD. The frequency of haplotype AA did not differ between patients with BD and controls (P=0.985). The haplotypes, AG, and GG, have positive and inverse association with BD susceptibility (P<0.001 and P<0.001, respectively). These findings suggest that IL-17 gene SNPs may influence the susceptibility of BD.

Il-17 Genetic and Immunophenotypic Evaluation in Chronic Graft-Versus-Host Disease

“…Until now, no other work was reported in the literature relating IL17F polymorphism and GVHD. We did not find association between IL17F genotypes and cGVHD; however other authors showed association between IL17F polymorphism (T/C 7488) and Behçet disease [21], gastric cancer [14], and bone mineral density [22].…”

Significant Association between <i>IL-17F</i> Promoter Region Polymorphism and Susceptibility to Asthma in a Korean Population

“…Most of these studies demonstrated an association between SNPs in exon 3 (especially rs763780) and disease susceptibility. A positive association between rs2397084 SNP in exon 3 of the IL-17F gene and Behçet’s disease was reported in a Korean population [11]. A significant association between the rs763780 SNP in exon 3 of the IL-17F gene and ulcerative colitis was observed in both Japanese and Chinese populations [12,13].…”

“…In our study, 2 polymorphisms (in the promoter region and in exon 3 of the IL-17F gene) were identified in a Korean population. Genetic association studies to define polymorphisms in the IL-17F gene have been performed for several immune disorders such as asthma, atopic dermatitis, psoriasis vulgaris, ulcerative colitis and Behçet’s disease [11,12,13,14]. Most of these studies demonstrated an association between SNPs in exon 3 (especially rs763780) and disease susceptibility.…”

The role of IL-23/IL-17 axis in the etiopathogenesis of Behçet's disease

“…These findings hinted that the IL-23/IL-17 pathway together with IFN-γ was associated with the active intraocular inflammation in BD [5]. In addition, authors also identified IL-23R and IL-17F gene polymorphisms which were associated with susceptibility to BD [6,7].…”