Interleukin-18 −607C/A Gene Polymorphism in Egyptian Asthmatic Children

Shaaban, Hala H.; Mohy, Abeer; Abdel-Razek, A. S.; Wahab, Amira Abdel

doi:10.1007/s40291-014-0097-0

Cited by 6 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SNaPShot, TaqMan, AS-PCR,PCR-RFLP, PCR-SSP and PCR-ARMS genotyping methods were used among the eligible literatures. Except for Lee CC 14 and Shaaban HH, 17 the genotype distributions among the controls of all eligible literatures were consistent with HWE. All studies have presented matching information, such as age and gender, except for the studies of Pawlik A, 6 Lee CC 14 and Higa S. 21…”

Section: Figure 1 Flow Diagram Of Included/excluded Studies In Meta-mentioning

confidence: 71%

“…6,13,15,16,18,20 The characteristics of the literatures are summarized in Table 1. For IL-18 polymorphisms, all the 8 studies (1851 cases and 1792 controls) for -607 A/C, 6,10,13,[15][16][17][18]20 8 studies (2646 cases and 7278 controls) for -137 G/C 6,[11][12][13]15,16,18,20 and 4 studies (1586 cases and 1004 controls) for -105 A/C 14,15,20,21 were conducted in the meta-analysis. Four studies were conducted in Asian, 13,15,18,20 tow in Caucasian, 6,16 and tow in African 10,17 for -607A/C; Five studies were conducted in Asian, 12,13,15,18,20 three in Caucasian 6,11,16 for 137 G/C; Four studies were conducted in Asian 14,15,20,21 for 105 A/C.…”

Section: Figure 1 Flow Diagram Of Included/excluded Studies In Meta-mentioning

confidence: 99%

“…Many studied suggested that the IL-18 polymorphisms were associated with asthma, [10][11][12][13][14] whereas some studies indicated that lack of an association between IL-18 polymorphisms and asthma. 6,[15][16][17][18] The inconsistent results may result in a single study or small sample size makes the lower statistical power. Ma and colleagues' 19 conducted a meta-analysis to evaluate the association between these polymorphisms (A-607C, G-137C) and the risk of asthma in 2012.…”

Section: Introductionmentioning

confidence: 99%

“…In the past few years, more studies concerning the association between the IL-18 polymorphisms (A-607C, G-137C) and the risk of asthma have been published in different regions. 12,13,17,18 We thought these studies should also be included, and we added a new polymorphism (A-105C) of IL-18. 14,15,20,21 Thus, the aim of our study is to use a systematic review and update meta-analysis to estimate the association between IL-18 polymorphisms (A-607C, G-137C, and A-105C) and asthma according to all published case-control studies.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis

Liu

Feng²,

Zhang

et al. 2019

IJAAI

View full text Add to dashboard Cite

Growing evidence indicated conflicting results that Interleukin-18 (IL-18) promoter polymorphisms rs1946518 (A-607C), rs187238 (G-137C) and rs549908 (A-105C) were associated with asthma risk. The aim of this study is to comprehensively evaluate the IL-18 polymorphisms and asthma by a systematic review and meta-analysis. A total of 12 studies testing the association between these polymorphisms and asthma were examined (8 studies for A-607C, 8 studies for G-137C, and 4 studies for A-105C) in the update meta-analysis, up to Dec 30, 2017. Summary odds ratios (ORs) and 95% confidence intervals (CI) were used to estimate the strength of association between each polymorphism and asthma using fixed- and random-effects models when appropriate. Heterogeneity and publication bias were evaluated. The meta-analysis results indicated that any allele frequencies of the IL-18 polymorphisms (A-607C, G-137C and A-105C) was not associated with asthma risk (p>0.05). And no statistically significant association was observed between genotype frequencies of these polymorphisms and asthma under different genetic models (p>0.05). Subgroup analysis results were similar to the main analysis by ethnicity, sample size, genotyping methods, matching criteria and quality score. There was no evidence of publication bias. The present meta-analysis suggests that IL-18 polymorphisms (A-607C, G-137C and A-105C) were unlikely to be associated with asthma risk.

show abstract

Section: Figure 1 Flow Diagram Of Included/excluded Studies In Meta-mentioning

confidence: 71%

Section: Figure 1 Flow Diagram Of Included/excluded Studies In Meta-mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis

Liu

Feng²,

Zhang

et al. 2019

IJAAI

View full text Add to dashboard Cite

show abstract

“…The synonymous variation in IL-18 rs549908 (105A/C) has been investigated for its association with asthma in a Chinese population where patients carrying the C/C homozygous genotype at rs549908 were observed to have a higher risk of developing asthma than those carrying the IL18 105A/C genotype (Lee et al, 2008). The association of the -607C/A genotype in the promoter region of IL-18 with asthma has been assessed, and although the frequency of the -607AA genotype appeared to be higher in Egyptian asthmatic children, the association was not statically significant (Shaaban et al, 2014) (Table 3)…”

Section: Introductionmentioning

confidence: 99%

Immune-related gene polymorphisms in pulmonary diseases

et al. 2017

View full text Add to dashboard Cite

Between the DNA sequences of two randomly-selected human genomes, which consist of over 3 billion base pairs and twenty five thousand genes, there exists only 0.1% variation and 99.9% sequence identity. During the last couple of decades, extensive genome-wide studies have investigated the association between single-nucleotide polymorphisms (SNPs), the most common DNA variations, and susceptibility to various diseases. Because the immune system's primary function is to defend against myriad infectious agents and diseases, the large number of people who escape serious infectious diseases underscores the tremendous success of this system at this task. In fact, out of the third of the global human population infected with Mycobacterium tuberculosis during their lifetime, only a few people develop active disease, and a heavy chain smoker may inexplicably escape all symptoms of chronic obstructive pulmonary disease (COPD), lung cancer, and other smoke-associated lung diseases. This may be attributable to the genetic makeup of the individual(s), including their SNPs, which provide some resistance to the disease. Pattern recognition receptors (PRRs), transcription factors, cytokines and chemokines all play critical roles in orchestrating immune responses and their expression/activation is directly linked to human disease tolerance. Moreover, genetic variations present in the immune-response genes of various ethnicities may explain the huge differences in individual outcomes to various diseases and following exposure to infectious agents. The current review focuses on recent advances in our understanding of pulmonary diseases and the relationship of genetic variations in immune response genes to these conditions.

show abstract