Interleukin 18 in the CNS

Alboni, Silvia; Cervia, Davide; Sugama, Shuei; Conti, Bruno

doi:10.1186/1742-2094-7-9

Cited by 255 publications

(212 citation statements)

References 165 publications

(182 reference statements)

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“…Additionally, prolonged allograft ischemic time has been associated with impaired gas exchange (i.e., Pa O 2 /FI O 2 ) immediately postoperatively (34) and impaired longterm survival. Confirmatory studies, designed to examine markers of oxidative stress (34,35), inflammation (e.g., IL-18) (35,(43)(44)(45), and oxygenation postoperatively as potential mediators of the observed relationships between allograft ischemic time, oxygenation, and cognitive function, are required to validate our observations. Related future studies are required to examine whether the previously identified relationship between prolonged allograft ischemic time and long-term survival (34) is mediated by cognitive impairment and the potential adverse events related to such impairment (i.e., functional impairment, medication nonadherence, infectious complications) (46,47).…”

Section: Original Researchmentioning

confidence: 86%

Cognitive Function, Mental Health, and Health-related Quality of Life after Lung Transplantation

Cohen

Christie²,

Anderson³

et al. 2014

Annals ATS

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Rationale: Cognitive and psychiatric impairments are threats to functional independence, general health, and quality of life. Evidence regarding these outcomes after lung transplantation is limited.Objectives: Determine the frequency of cognitive and psychiatric impairment after lung transplantation and identify potential factors associated with cognitive impairment after lung transplantation.Methods: In a retrospective cohort study, we assessed cognitive function, mental health, and health-related quality of life using a validated battery of standardized tests in 42 subjects posttransplantation. The battery assessed cognition, depression, anxiety, resilience, and post-traumatic stress disorder (PTSD). Cognitive function was assessed using the Montreal Cognitive Assessment, a validated screening test with a range of 0 to 30. We hypothesized that cognitive function post-transplantation would be associated with type of transplant, cardiopulmonary bypass, primary graft dysfunction, allograft ischemic time, and physical therapy posttransplantation. We used multivariable linear regression to examine the relationship between candidate risk factors and cognitive function post-transplantation.Measurements and Main Results: Mild cognitive impairment (score, 18-25) was observed in 67% of post-transplant subjects (95% confidence interval [CI]: 50-80%) and moderate cognitive impairment (score, 10-17) was observed in 5% (95% CI, 1-16%) of post-transplant subjects. Symptoms of moderate to severe anxiety and depression were observed in 21 and 3% of post-transplant subjects, respectively. No transplant recipients reported symptoms of PTSD. Higher resilience correlated with less psychological distress in the domains of depression (P , 0.001) and PTSD (P = 0.02). Prolonged graft ischemic time was independently associated with worse cognitive performance after lung transplantation (P = 0.001).The functional gain in 6-minute-walk distance achieved at the end of post-transplant physical rehabilitation (P = 0.04) was independently associated with improved cognitive performance post-transplantation.Conclusions: Mild cognitive impairment was present in the majority of patients after lung transplantation. Prolonged allograft ischemic time may be associated with cognitive impairment. Poor physical performance and cognitive impairment are linked, and physical rehabilitation post-transplant and psychological resilience may be protective against the development of long-term impairment. Further study is warranted to confirm these potential associations and to examine the trajectory of cognitive function after lung transplantation.Keywords: lung transplantation; cognitive function; psychological function; quality of life; critical illness

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Section: Original Researchmentioning

confidence: 86%

Cognitive Function, Mental Health, and Health-related Quality of Life after Lung Transplantation

Cohen

Christie²,

Anderson³

et al. 2014

Annals ATS

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“…In contrast, IL-18 was originally identified as an interferon-␥-inducing factor, and can enhance the production of other inflammatory molecules such as IL-1␤, tumor necrosis factor-␣, and the inducible form of nitric oxide synthase. 25 The precise pathway between inflammation process and SVD is largely unknown and needs additional investigation. Our results have some limitations.…”

Section: Discussionmentioning

confidence: 99%

Relations of Blood Inflammatory Marker Levels With Cerebral Microbleeds

Miwa

Tanaka

Okazaki

et al. 2011

Stroke

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Background and Purpose-Cerebral microbleeds (CMB) are observed in the elderly and have been regarded as one of the manifestations of small vessel disease. Although inflammatory processes have attracted much attention not only in large-artery disease, but also in small vessel disease, their involvement in CMB remains to be determined. The purpose of this study is to clarify relations between inflammatory marker levels and CMB. Methods-Four hundred thirty-one patients without histories of cerebrovascular diseases were prospectively enrolled. The presence and number of CMB were assessed on gradient-echo magnetic resonance imaging. As common inflammatory markers, serum levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and interleukin-18 (IL-18) were evaluated. Results-CMB were found in 65 patients (15%). In 35 patients, at least one CMB was found in deep locations, but 30 patients had strictly lobar CMB. Levels of hsCRP, IL-6, and IL-18 were higher in patients with CMB than in those without. Logistic regression analyses showed that each 1SD increase in each inflammatory marker level was significantly associated with the presence of CMB after adjustment for age and sex, and after additional adjustment for cardiovascular risk factors, silent lacunar infarction, and white matter hyperintensity. The OR (95% CI) of hsCRP, IL-6, and IL-18 was 1.81 (1.35-2.46), 1.73 (1.18 -2.61), and 2.41 (1.44 -4.52), respectively. Furthermore, the inflammatory marker levels were associated with both deep and lobar CMB. Conclusions-Higher levels of hsCRP, IL-6, and IL-18 are associated with CMB, in both deep and lobar locations, suggesting the involvement of inflammation in CMB. (Stroke. 2011;42:3202-3206.)

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“…После секреции он связывается либо с ИЛ-18-рецепторным антагонистом, инактивирующим его, либо с комплексом, состоящим из рецептора ИЛ-1R5 и ИЛ-18-дополняющего белка (ИЛ-1R7). После формирования лиганд-рецепторного соединения к нему прикрепля-ются цитозольные белки MyD88 (myeloid differentiation primary response gene 88) и IRAK-1 (interleukin-1 receptorassociated kinase 1), активирующие транскрипционный фактор NF-κB [3,10]. Активация ИЛ-18 может приводить к усилению цикла ИФН-γ/ИЛ-18: ИЛ-18 индуцирует образование лимфоцитами ИФН-γ, который стимулирует моноциты/макрофаги с увеличением их ICE-активности, что способствует синтезу ИЛ-18 [8].…”

Section: особенности строения и активации членов семейства ил-1unclassified

“…Иммуносупрессивное воздействие избытка глюкокортикоидов сопровождается снижением числа циркулирующих в крови Т-и В-лимфоцитов, моно-цитов, эозинофилов и базофилов, ограничением способ-ности макрофагов к фагоцитозу и киллингу злокаче-ственно трансформированных клеток [11]. Установлено, что ИЛ-18 способен угнетать нейроэндокринную деятель-ность, проявляя антагонизм по отношению к эффектам ИЛ-1β [10,18].…”

Section: биологические свойства цитокинов семейства ил-1unclassified

The Role of Interleukin-1 and Associated Cytokines in Gastric Carcinogenesis

Матвеева

Мосина

2012

Annals RAMS

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Interleukin 18 in the CNS

Cited by 255 publications

References 165 publications

Cognitive Function, Mental Health, and Health-related Quality of Life after Lung Transplantation

Cognitive Function, Mental Health, and Health-related Quality of Life after Lung Transplantation

Relations of Blood Inflammatory Marker Levels With Cerebral Microbleeds

The Role of Interleukin-1 and Associated Cytokines in Gastric Carcinogenesis

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