Interleukin-1β and Ibuprofen Effects on CD4/CD8 Cells after Endotoxic Challenge

Mansilla‐Roselló, Alfonso; Ferrón-Orihuela, José Antonio; Ruiz‐Cabello, Francisco; Garrote-Lara, Daniel; Delgado-Carrasco, S.; Tamayo-Pozo, F.

doi:10.1006/jsre.1996.0347

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…The CD4 + /CD8 + ratio is widely accepted as an indicator of immune activity (22), and also provides valuable prognostic information for patients with certain type of tumor, such as renal cell carcinoma (23) and metastatic melanoma (24). In the present study, an increased CD4 + /CD8 + ratio was detected in patients with MODS, indicating elevated immunoactivity in these patients.…”

Section: Discussionsupporting

confidence: 57%

Characteristics of CD4+CD25+Foxp3+ regulatory T cells in patients with multiple organ dysfunction syndrome

Zang

Jiang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Multiple organ dysfunction syndrome (MODS) is a systemic inflammation. The aim of the present study was to evaluate the role of CD4 + CD25 + Foxp3 + regulatory T cells (Treg) in patients with MODS and to determine the association between Treg cells and serum cytokine levels. The percentage of Treg in 42 MODS patients and 10 healthy subjects was evaluated using flow cytometry. Serum levels of cytokines were measured using an enzyme-linked immunosorbent assay.

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Section: Discussionsupporting

confidence: 57%

Characteristics of CD4+CD25+Foxp3+ regulatory T cells in patients with multiple organ dysfunction syndrome

Zang

Jiang

et al. 2016

Experimental and Therapeutic Medicine

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“…Thus, it is assumed that CXCLi2 expressed in the granulosa and theca layers of follicles and stroma in response to LPS might directly or indirectly recruit CD4 + T cells in the ovarian follicles and stroma. In a mouse model study, IL-1β stimulated the clonal expression of CD4 + T cells and increased CD4:CD8 ratio due to the increased CD4 + T cells (Mansilla-Roselló et al, 1996). In the current study, CD4 + T cells were increased in frequency in both theca and stroma, but the changes in the frequency of CD8 + T cells were not significant.…”

Section: Figurementioning

confidence: 59%

Effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokines and influx of leukocytes in the hen ovary

2011

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The aim of this study was to determine whether the expression of proinflammatory cytokines and chemokines in ovarian cells was changed to recruit heterophils and T cells in response to lipopolysaccharide (LPS), a gram-negative bacterial component. White Leghorn laying hens were intravenously injected with LPS or saline and their ovarian follicles and stroma were collected. Changes in the mRNA expression of IL-1β, IL-6, and CXCLi2 in the theca and granulosa layers and ovarian stroma were analyzed by quantitative reverse transcriptase PCR, whereas proteins of IL-1β and IL-6 were also identified by Western blot analysis. Localization of heterophil-like cells and CD4(+) and CD8(+) T cells was examined by general histology and immunohistochemistry. The expressions of IL-1β, IL-6, and CXCLi2 were significantly increased in the granulosa layer, theca layer, and stroma tissues by 3 to 6 h after LPS injection. Increase of IL-1β and IL-6 proteins in those tissues was also identified 12 h after LPS injection. The LPS stimulation resulted in the increased influx of heterophil-like cells and CD4(+) T cells, but not CD8(+) cells, in the theca layers of follicles. Saline injection affected neither expression of examined proinflammatory cytokines and chemokines nor frequencies of immunocompetent cells. These results suggest that ovarian follicular cells and stromal cells have the ability to express proinflammatory cytokines and chemokines, and their expression is upregulated by LPS in association with the recruitment of heterophil-like cells and T cells. These responses may play roles in local host defense in ovarian follicles.

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Section: Discussionmentioning

confidence: 99%

“…The CD4 + /CD8 + ratio of T cells, is considered to be a good indicator of immune function (44). During sepsis, the reduction of CD4 + /CD8 + ratio is closely related to sepsis-induced immunosuppression (45). Xia et al reported that the CD4 + /CD8 + ratio in patients of sepsis were significantly lower than those in patients with a non-sepsis diagnosis (46).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Sepsis Exacerbates CD4+ T Cell Exhaustion and Decreases Antiviral Immune Responses

Xiao

et al. 2021

Front. Immunol.

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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. It is a disease with a high incidence, mortality, and recurrence rate and frequently results in its survivors requiring readmission into hospitals. The readmission is mainly due to recurrent sepsis. Patients with recurrent sepsis are more susceptible to secondary infections partly due to immune dysfunction, leading to a higher mortality in the long term. However, there remains a gap in the understanding of immunological characteristics and underlying mechanisms of recurrent sepsis. In this study, we used mouse models of acute and recurrent sepsis to investigate their different immunological characteristics. And then we subjected the two mouse models to a secondary influenza A virus (H1N1) infection and characterized the different immune responses. Here, we demonstrated that CD4+ T cells present an exacerbated exhaustion phenotype in response to recurrent sepsis as illustrated by the decreased frequency of CD4+ T cells, reduced co-stimulatory CD28 and increased inhibitory PD-1 and Tim-3 expression on CD4+ T cells, increased frequency of regulatory T cells, and reduced MHC-II expression on antigen-presenting cells. Moreover, we showed that antiviral immune responses decrease in the recurrent sepsis mouse model subjected to a secondary infection as illustrated by the reduced pathogen clearance and inflammatory response. This may be a consequence of the exacerbated CD4+ T cell exhaustion. In summary, recurrent sepsis exacerbates CD4+ T cell exhaustion and decreases antiviral immune responses, contributing to significant morbidity, increased late mortality, and increased health care burden in recurrent sepsis patients.

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Interleukin-1β and Ibuprofen Effects on CD4/CD8 Cells after Endotoxic Challenge

Cited by 5 publications

References 5 publications

Characteristics of CD4+CD25+Foxp3+ regulatory T cells in patients with multiple organ dysfunction syndrome

Characteristics of CD4+CD25+Foxp3+ regulatory T cells in patients with multiple organ dysfunction syndrome

Effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokines and influx of leukocytes in the hen ovary

Recurrent Sepsis Exacerbates CD4+ T Cell Exhaustion and Decreases Antiviral Immune Responses

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