Interleukin-2, Interferon-gamma Gene Polymorphisms in Recurrent Aphthous Stomatitis

Najafi, Shamsoulmolouk; Yousefi, Hadi; Mohammadzadeh, Mohammad; Bidoki, Alireza Zare; Farhadi, Elham; Rezaei, Nima

doi:10.14712/23362936.2017.7

Cited by 10 publications

(15 citation statements)

References 15 publications

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“…The study population included only 74 patients with RAS. However, the number of patients from this Czech population is comparable with the size of cohorts in other studies; see Table S1 . Another drawback of this study is that the levels of IL‐2, IL‐4, IL‐4R α , IL‐10, and IL‐13 were not measured; however, the functional relevance of the gene variants selected for the analysis is mostly known.…”

Section: Discussionmentioning

confidence: 84%

“…This is in line with the results of a study by SUN et al (38), also showing that MAFs are similar in Chinese healthy subjects and Czech controls. On the other hand, protective and risk IL2 genotypes were associated with RAS in an Iranian population (39). The differences between these studies may be a result of interpopulation genetic diversity; therefore, further studies in different ethnic groups and larger samples are needed.…”

Section: Discussionmentioning

confidence: 94%

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Recurrent aphthous stomatitis and gene variability in selected interleukins: a case–control study

Linhartová

Jánoš

Slezaková

et al. 2018

European J Oral Sciences

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Genetic factors, especially those related to immune system functioning, have been intensively studied to determine their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukin (IL)2, IL4 (and its receptor α, IL4Rα), IL10, and IL13, which were selected based on literature review and/or their functional relevance, in Czech patients with RAS and in healthy controls. In total, 252 subjects (178 controls and 74 patients with RAS) were enrolled in this case–control study, and their detailed anamnestic, clinical, and laboratory data were obtained. Nine polymorphisms in the genes encoding interleukins were determined using PCR techniques. There were no significant differences in allele or genotype frequencies of the IL2, IL4, IL4Rα, IL10, and IL13 polymorphisms rs2069762/rs2069763, rs2243250/rs79071878, rs1801275, rs1800896, and rs1800925, respectively, between controls and patients with RAS. The minority alleles rs1800871 and rs1800872, which encode variants of IL10, were associated with a statistically significantly higher risk of RAS, as confirmed by the results of genotype and haplotype analyses. We suggest that variability in the IL10 gene may play an important role in the development of RAS in the Czech population.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 94%

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case–control study

Linhartová

Jánoš

Slezaková

et al. 2018

European J Oral Sciences

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“…Recurrent aphthous stomatitis (RAS) is the most common oral painful ulcerative inflammatory disease of unknown etiology; thereby its management has been remained a challenge yet (25). Compelling evidences demonstrate that some immune dysfunctions may underlie RAS pathogenesis (26). This report is of importance for dentists aimed at strengthening therapeutic modalities.…”

Section: Xerostomia and Hyposalivationmentioning

confidence: 83%

“…NSAIDs, which are responsible for approximately 5-10% of all medications prescribed each year (35), and β-blockers are the most common drugs responsible for oral LP (26). Antihypertensive medications are major culprits for GT [ Table 5].…”

Section: Resultsmentioning

confidence: 99%

An Update on Drug-induced Oral Reactions

Yousefi¹,

Abdollahi²

2018

J Pharm Pharm Sci

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-Adverse drug reactions (ADRs) are one of the major culprits in the development of oral lesions, which can be misdiagnosed with underlying diseases. The goal of this study is to summarize and update the current knowledge about drug-induced oral reactions. Electronic searches were performed in Scopus, Google Scholar, Cochrane and PubMed databases, for articles published between January 2008 and August 2017. Two authors screened the titles and abstracts for eligibility. Finally, 56 studies included in this review. There was no systematic homogeneity in the included studies; thereby no meta-analysis was performed. The most frequent oral ADR was xerostomia, and the most reported cause was antihypertensive medications. Cardiovascular drugs were the most reported culprit agents for induction of oral ulcerative and vesiculo-bullous lesions, followed by methotrexate. Nonsteroidal anti-inflammatory drugs (NSAIDs) and β-blockers were found the most common responsible drugs for induction of oral lichen planus.

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“…FCOD is a non-malignant fibro-osseous lesion, having multifocal involvement in the tooth-bearing areas of the mandible. 6 Despite several evidences of familial and genetic predilection of some oral lesions, 7 , 8 FCOD has a poor familial and genetic background. 9 , 10 Clinically, this reactive lesion is asymptomatic, although the probability of dull pain, exposure of alveolar bone into the oral cavity, and alveolar sinus tract arising from secondary infection is quite possible.…”

Section: Discussionmentioning

confidence: 99%

Success of Dental Implant Osseointegration in a Florid Cemento-Osseous Dysplasia: A Case Report with 8-Year Follow-Up

Shadid

Kujan

2020

Clinics and Practice

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Florid cemento-osseous dysplasia (FCOD) is a rare benign fibro-osseous lesion which affects multiple quadrants and predominantly the mandible. This case report presents a successful implant placement with 8-year of follow-up in a 44-yearold woman asking for a fixed restoration in mandibular right posterior edentulous area. Radiographic images showed lobular, irregularly shaped radiopacities and radiolucencies almost symmetrically observed in the premolar-molar area of the right and left regions of the mandible. The findings of Xray images were attributable to FCOD. Minimally invasive two-stage surgery with strict infection control was followed to place two implants in lower right posterior region. The implants demonstrated clinically rigid fixation and restored successfully after 6 months. A direct functional connection between dysplastic bone and the implant load bearing surface was evidenced by the lack of symptoms, and the lack of soft tissues inflammation or peri-implant bone loss up to 8 years follow-up.

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Interleukin-2, Interferon-gamma Gene Polymorphisms in Recurrent Aphthous Stomatitis

Cited by 10 publications

References 15 publications

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case–control study

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case–control study

An Update on Drug-induced Oral Reactions

Success of Dental Implant Osseointegration in a Florid Cemento-Osseous Dysplasia: A Case Report with 8-Year Follow-Up

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