Interleukin 2 Pseudomonas Exotoxin (IL2-PE664Glu) Chimeric Protein Kills B Cells from Patients with Myasthenia Gravis

Human toxin-based recombinant immunotoxins/chimeric proteins as a drug delivery system for targeted treatment of human diseases

“…To validate the use of proapoptotic proteins as the killing moiety in chimeric proteins, the author and co-workers had chosen a well-known target, the IL-2R targeted by its ligand --the human IL-2. A classical bacterial-based chimeric protein such as IL-2-PE had already been reported to eliminate successfully activated T cells, both in vitro and in vivo [86][87][88][89][90][91][92][93][94][95][96][97][98][99]. In the IL-2-Bax chimeric protein, the killing domain is Bax, the proapoptotic protein of the Bcl-2 family.…”