Interleukin-21 activates natural killer cell activity against cetuximab-coated pancreatic tumor cells

McMichael, Elizabeth L.; Jaime-Ramirez, Alena Cristin; Guenterberg, Kristan; Luedke, Eric; Atwal, Lakhvir S.; Carson, William E.

doi:10.1186/2051-1426-3-s2-p233

Cited by 2 publications

(2 citation statements)

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“…Not only are activating and inhibitory receptors important for stimulating NK cell cytotoxicity but they also strictly control cytokine and chemokine secretions that further drive antitumor reactions ( 23 ). In addition to stimulation by activating receptors, NK cell activity can be enhanced by certain cytokines, notably IFN-γ, interleukin (IL)-2, IL-12, IL-15, IL-18, and IL-21 ( 24 – 29 ).…”

Section: Importance Of Nk Cells In the Elimination Of Cancer Cellsmentioning

confidence: 99%

Acquired Natural Killer Cell Dysfunction in the Tumor Microenvironment of Classic Hodgkin Lymphoma

2018

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An understanding of interactions within the tumor microenvironment (TME) of classic Hodgkin lymphoma (cHL) has helped pave the way to novel immunotherapies that have enabled dormant and tumor-tolerant immune cells to be reactivated. The immunosuppressive nature of the TME in cHL specifically inhibits the proliferation and activity of natural killer (NK) cells, which contributes to tumor immune-escape mechanisms. This deficiency of NK cells begins at the tumor site and progresses systemically in patients with advanced disease or adverse prognostic factors. Several facets of cHL account for this effect on NK cells. Locally, malignant Reed–Sternberg cells and cells from the TME express ligands for inhibitory receptors on NK cells, including HLA-E, HLA-G, and programmed death-ligand 1. The secretion of chemokines and cytokines, including soluble IL-2 receptor (sCD25), Transforming Growth Factor-β, IL-10, CXCL9, and CXCL10, mediates the systemic immunosuppression. This review also discusses the potential reversibility of quantitative and functional NK cell deficiencies in cHL that are likely to lead to novel treatments.

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Section: Importance Of Nk Cells In the Elimination Of Cancer Cellsmentioning

confidence: 99%

Acquired Natural Killer Cell Dysfunction in the Tumor Microenvironment of Classic Hodgkin Lymphoma

2018

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“…Whether used as a monotherapy or in combination with immune checkpoint blockades (PD-1, T cell immunoglobulin, or ITIM domain (immunoreceptor tyrosine-based inhibitory motif)), enhanced anti-tumor efficacy results (106). In addition, IL-21 stimulates NK cells and leads NK cells to have stronger ADCC effects on cetuximab-treated pancreatic cancer cells (107). Phase I/II clinical trials include the IL-21/PD-L1 fusion protein AMG-256 (NCT04362748) initiated by Amgen, BMS-982470 (rIL-21) in combination with BMS-936558 (anti-PD-1) for solid tumors (NCT01629758) and rIL-21 combined with rituximab or sorafenib for non-Hodgkin's lymphoma (NCT00347971) or metastatic renal cell carcinoma (NCT00389285).…”

Section: Il-21mentioning

confidence: 99%

The application of Interleukin-2 family cytokines in tumor immunotherapy research

Zhou

Quan

Liu³

et al. 2023

Front. Immunol.

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The Interleukin-2 Family contains six kinds of cytokines, namely IL-2, IL-15, IL-4, IL-7, IL-9, and IL-21, all of which share a common γ chain. Many cytokines of the IL-2 family have been reported to be a driving force in immune cells activation. Therefore, researchers have tried various methods to study the anti-tumor effect of cytokines for a long time. However, due to the short half-life, poor stability, easy to lead to inflammatory storms and narrow safety treatment window of cytokines, this field has been tepid. In recent years, with the rapid development of protein engineering technology, some engineered cytokines have a significant effect in tumor immunotherapy, showing an irresistible trend of development. In this review, we will discuss the current researches of the IL-2 family and mainly focus on the application and achievements of engineered cytokines in tumor immunotherapy.

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Interleukin-21 activates natural killer cell activity against cetuximab-coated pancreatic tumor cells

Abstract: McMichael et al.: Interleukin-21 activates natural killer cell activity against cetuximab-coated pancreatic tumor cells.

Cited by 2 publications

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Acquired Natural Killer Cell Dysfunction in the Tumor Microenvironment of Classic Hodgkin Lymphoma

Acquired Natural Killer Cell Dysfunction in the Tumor Microenvironment of Classic Hodgkin Lymphoma

The application of Interleukin-2 family cytokines in tumor immunotherapy research

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