Interleukin-24 inhibits osteosarcoma cell migration and invasion via the JNK/c-Jun signaling pathways

Zhuo, Baobiao; Shi, Yingchun; Qin, Haihui; Sun, Qingzeng; Zhang, Fengfei; Wang, Rong; Wang, Xiaodong

doi:10.3892/ol.2017.5990

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…A number of studies have demonstrated that JNK and ERK transcriptionally regulate the expression of MMP‐2 and MMP‐9, which results in regulation of cell migration and invasion . IL‐24 was overexpressed in osteosarcoma 143B cells through the activation of JNK/c‐Jun was inhibited and downregulation of MMP‐2 and MMP‐9 expression . Our results are consistent with the above studies, and we demonstrated that the sustained activation of ERK1/2 or JNK1/2 and the inhibition of MMP‐2 and MMP‐9 were involved in the β‐mangostin‐inhibited migration and invasion in HCC cells.…”

Section: Discussionsupporting

confidence: 92%

β‐mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP‐2 and MMP‐9 expression and activating the ERK and JNK pathways

Huang

Teng

et al. 2017

Environmental Toxicology

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β-mangostin is a dietary xanthone that has been reported to have the anticancer properties in some human cancer cell types. However, the antimetastatic effect and molecular mechanism of β-mangostin action in human hepatocellular carcinoma (HCC) cells remain unknown. In this study, we found that β-mangostin did not induce cytotoxicity in human HCC cells (SK-Hep-1, Huh-7 and HA22T/VGH cells). β-mangostin could inhibit migration and invasion of human HCC cells. Meanwhile, β-mangostin significantly decreased the protein activities and expression of matrix metalloproteinase (MMP)-2 and MMP-9 via increasing the activation of MEK1/2, ERK1/2, MEK4 and JNK1/2 signaling pathways. Furthermore, using specific inhibitor for ERK1/2 (PD98059) and JNK1/2 (JNKII) significantly restored the expression of MMP-2/-9 and invasion by β-mangostin treatment in Huh-7 cells. In addition, β-mangostin effectively restored the protein levels and transcription activity of MMP-2 and MMP-9 in siERK or siJNK-transfected Huh-7 cells, concomitantly with promotion on cell migration and invasion. Taken together, these findings are the first to demonstrate the antimetastatic activity of β-mangostin against human HCC cells, which may act as a promising therapeutic agent for the treatment of HCC.

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Section: Discussionsupporting

confidence: 92%

β‐mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP‐2 and MMP‐9 expression and activating the ERK and JNK pathways

Huang

Teng

et al. 2017

Environmental Toxicology

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“…Several studies have indicated that the MAPK signal pathway plays a vital role in regulating the enzyme activity and protein expression of MMPs . Our results have revealed that kaempferol‐treated ARPE‐19 cells can phosphorylate ERK1/2 (Figure A) as well as decrease the expression and activity of MMP‐2 (Figure A,C).…”

Section: Discussionsupporting

confidence: 51%

Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE‐19 cells

Chien

Wang

Chang

et al. 2018

Environmental Toxicology

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Kaempferol is a flavonoid with anticancer and anti-metastasis activity in different cancer-cell lines. However, the underlying mechanisms by which kaempferol acts on human retinal pigment epithelial (ARPE-19) cells remain unclear. In this study, we demonstrated that kaempferol inhibited migration and invasion in ARPE-19 cells at non-toxic dosages. We discovered that kaempferol obviously reduced the enzyme activity and protein expression of matrix metalloproteinase-2 by increasing the phosphorylated levels of extracellular signal-regulated kinases 1/2 (ERK1/2) signaling pathways. Additionally, ERK1/2-specific inhibitor PD98059 significantly reversed kaempferol's inhibitory effects on migration and expression of MMP-2 in ARPE-19 cells. Overall, our results are the first to demonstrate that kaempferol is capable of inhibiting cell migration by targeting ERK1/2 signaling in human retinal pigment epithelial cells. K E Y W O R D S ERK1/2 signaling, kaempferol, migration, MMP-2

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“…Both assays revealed a stronger effect of the C3G + DDP combination on HeLa cells than that by the corresponding single treatments. Previous studies have shown that phytochemicals such as daphnoretin and grape seed extracts inhibited the migration and invasion of tumor cells (Meo et al, 2019;Yu et al, 2019), which may hinder cancer development and improve response to treatment (Zhuo et al, 2017). Polyphyllin I inhibits the growth and invasion of DDP-resistant gastric cancer cells (Zhang et al, 2018).…”

Section: Effects Of C3g Ddp and Their Combination On Invasion And Migration Of Hela Cellsmentioning

confidence: 99%

Cyanidin‐3‐O‐glucoside and cisplatin inhibit proliferation and downregulate the PI3K/AKT/mTOR pathway in cervical cancer cells

Zhao

Yan

et al. 2021

Journal of Food Science

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Natural compounds have been increasingly investigated as substances enhancing the effect of drugs and reducing drug‐related adverse reactions. The objective of this study was to determine how a combination of cisplatin (DDP) with cyanidin‐3‐O‐glucoside (C3G) affected malignancy features of cervical cancer cells. The results demonstrated that the proliferation of HeLa cells treated with 5 µg/ml DDP, 400 µg/ml C3G, or a combination of both (5 µg/ml DDP and 400 µg/ml C3G) was inhibited by 17.43%, 34.98%, and 63.38%, respectively. The IC50 values for DDP and the DDP/C3G combination treatments in HeLa cells were 18.53 and 6.435 µg/ml, respectively. Flow cytometry analysis indicated that treatment with DDP, C3G, or the combination induced G1 cell cycle arrest and apoptosis in HeLa cells. Furthermore, after treatment, cyclin D1 and Bcl‐2 levels decreased; Bax, cleaved caspase‐3, p53, and TIMP‐1 were activated; and the PI3K/AKT/mTOR signaling pathway was modulated. These anticancer effects were enhanced in cells treated with the combination of DDP and C3G compared to those treated with DDP or C3G alone. Our study indicates that C3G increases the antitumor activity of DDP, suggesting a potential strategy to reduce adverse effects associated with chemotherapy in cervical cancer. Practical Application Natural biologically active food ingredients are suggested to have a potential to enhance the effect of chemotherapy in cancer. We believe that our study makes a significant contribution to the literature because it revealed, for the first time, that C3G could increase the antitumor activity of DDP, suggesting a potential strategy to reduce adverse effects associated with chemotherapy in cervical cancer.

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Interleukin-24 inhibits osteosarcoma cell migration and invasion via the JNK/c-Jun signaling pathways

Cited by 10 publications

References 32 publications

β‐mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP‐2 and MMP‐9 expression and activating the ERK and JNK pathways

β‐mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP‐2 and MMP‐9 expression and activating the ERK and JNK pathways

Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE‐19 cells

Cyanidin‐3‐O‐glucoside and cisplatin inhibit proliferation and downregulate the PI3K/AKT/mTOR pathway in cervical cancer cells

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