2021
DOI: 10.1016/j.cytogfr.2020.10.003
|View full text |Cite
|
Sign up to set email alerts
|

Interleukin-26 in host defense and inflammatory disorders of the airways

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
11
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
5
1

Relationship

2
4

Authors

Journals

citations
Cited by 10 publications
(13 citation statements)
references
References 55 publications
2
11
0
Order By: Relevance
“…This interpretation is supported by the fact that type II alveolar epithelial cells, macrophages, and neutrophils released IL-26 as early as 3 h after the exposure to bacterial stimuli. Indeed, there is further evidence supporting this hypothesis in the literature showing that alveolar macrophages, T cells (6,8,9), bronchial epithelial cells (10), and lung fibroblasts (11) isolated from healthy human lungs display prestored as well as inherent release of IL-26 protein (6). Moreover, it is noteworthy that the protein concentrations of IL-26 in BW samples decreased with the duration of symptoms, an observation that is compatible with this cytokine reflecting early and critical events during bacterial lung infection.…”
Section: Discussionsupporting
confidence: 61%
See 3 more Smart Citations
“…This interpretation is supported by the fact that type II alveolar epithelial cells, macrophages, and neutrophils released IL-26 as early as 3 h after the exposure to bacterial stimuli. Indeed, there is further evidence supporting this hypothesis in the literature showing that alveolar macrophages, T cells (6,8,9), bronchial epithelial cells (10), and lung fibroblasts (11) isolated from healthy human lungs display prestored as well as inherent release of IL-26 protein (6). Moreover, it is noteworthy that the protein concentrations of IL-26 in BW samples decreased with the duration of symptoms, an observation that is compatible with this cytokine reflecting early and critical events during bacterial lung infection.…”
Section: Discussionsupporting
confidence: 61%
“…From a hypothetical point-of-view, the effect that we observed may be a unique feature of IL-26 that positions this cytokine as modulatory factor for innate immune response, displaying a homeostatic potential that may be beneficial for ascertaining adequate but limited innate immune responses over time after activation (28,(32)(33)(34). Clearly, the herein described effects of IL-26 motivate more in-depth investigations of the specific underlying mechanisms, taking into consideration the fact that IL-26 can exert effects independent of the one receptor complex that has been described so far (6).…”
Section: Discussionmentioning
confidence: 78%
See 2 more Smart Citations
“…However, little is known about the role of Th17 cytokines other than IL-17A. This is particularly true for interleukin (IL)-26, a member of the IL-10 family of cytokines, that is produced by Th17 cells, macrophages, and other leukocytes in the airways [ 14 18 ]. Importantly, this cytokine contributes to the local mobilization of neutrophils through chemokine release and potentiation of chemotaxis that is induced by other, pro-inflammatory stimuli including the archetype chemokine IL-8 [ 18 ].…”
Section: Introductionmentioning
confidence: 99%