Interleukin-32 Increases Human Gastric Cancer Cell Invasion Associated with Tumor Progression and Metastasis

Tsai, Chun‐Yi; Wang, Chia Siu; Tsai, Ming-Ming; Cheng, Hsiang; Cheng, Wanli; Tseng, Yi-Chuan; Chen, Cheng-Yi; Lin, Crystal D.; Wu, Jun; Wang, Lu Hai; Lin, Kwang Huei

doi:10.1158/1078-0432.ccr-13-1221

Cited by 94 publications

(113 citation statements)

References 34 publications

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“…In another study, IL-32 levels were found to be elevated in gastritis tissues and GC tissues compared to those in healthy gastric mucosa [38]. Tsai et al concluded that IL-32 expression was higher in 48 of 66 (74 %) GC tissues than that in paired noncancerous tissues (p<0.001) [28]. Fukamachi et al reported that tissues with colon, gastric, and renal cancers showed increased IL-32 expression compared to tissues from non-tumorous regions of the same patients [39].…”

Section: Discussionmentioning

confidence: 95%

“…Similarly, Tsai et al reported that IL-32 was significantly upregulated in GC and high expression of IL-32 in GC was associated with tumor progression and poor prognosis. They suggested that IL-32 was involved in cell migration and invasion in GC and IL-32 was significantly increased in patients with lymph node metastasis (p=0.005) [28]. After investigating the role of IL-32 expression in lung cancer, Sorrentino et al concluded that IL-32 was overexpressed mainly in advanced stage lung cancers and patients with IL-32-positive cancers developed lymph node metastases more readily.…”

Section: Discussionmentioning

confidence: 99%

“…Overexpression of IL-32 was detected in gastric [21,22], lung [23], pancreas [24], hepatocellular [25], and esophagus [26] cancer tissues. IL-32 increases the migration and invasion of several cancers, such as breast, gastric, and lung [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of serum interleukin-29, interleukin-32, and tumor necrosis factor alpha levels in patients with gastric cancer

et al. 2015

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Many studies suggested that cytokines interleukin (IL)-29, IL-32, and tumor necrosis factor alpha (TNF-α) are implicated in the pathogenesis of malignancies. The purpose of this study was to determine the clinical significance of the serum levels of IL-29, IL-32, and TNF-α in gastric cancer (GC) patients. Fifty-eight GC patients and 20 age- and sex-matched healthy controls were enrolled into this study. The median age at diagnosis was 59.5 years (range 32-82 years). Tumor localization of the majority of the patients was antrum (n = 42, 72.4 %), and tumor histopathology of the majority of the patients was diffuse (n = 43, 74.1 %). The majority of the patients had stage IV disease (n = 41, 70.7 %). Thirty-six (62.1 %) patients had lymph node involvement. The median follow-up time was 66 months (range 1 to 97.2 months). The baseline serum IL-29 concentrations were not different between patients and controls (p = 0.627). The baseline serum IL-32 and TNF-α concentrations of the GC patients were significantly higher (for IL-32, p = 0.014; for TNF-α, p = 0.001). Gender, localization, histopathology, tumor, and lymph node involvement were not found to be correlated with serum IL-29, IL-32, and TNF-α concentrations (p > 0.05). Patients without metastasis (p = 0.01) and patients who responded to chemotherapy (p = 0.04) had higher serum IL-29 concentrations. Patients older than 60 years had higher serum IL-32 (p = 0.002). Serum IL-29, IL-32, and TNF-α levels were not associated with outcome (p = 0.30, p = 0.51, and p = 0.41, respectively). In conclusion, serum levels of IL-32 and TNF-α may be diagnostic markers, and serum IL-29 levels may be associated with good prognosis in patients with GC.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Clinical significance of serum interleukin-29, interleukin-32, and tumor necrosis factor alpha levels in patients with gastric cancer

et al. 2015

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“…In clear cell renal cell carcinoma patients, IL-32 overexpression was associated with disease progression and poor overall survival, indicating that IL-32 may be a novel prognostic factor for predicting outcomes in this disease [26]. Similarly, IL-32 has been reported as a poor prognostic marker for gastric cancer [27,28]. Using the lung cancer A549 cell line, IL-32 inhibition reduced cell viability, migration and invasion, whereas IL-32 overexpression increased migration and invasion, indicating that this protein participates in the malignant phenotype of lung cancer cells [24].…”

Section: Discussionmentioning

confidence: 99%

IL32 expression in peripheral blood CD3+ cells from myelodysplastic syndromes patients

et al. 2017

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Background: Myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterized by ineffective hematopoiesis and risk of leukemia transformation. There is evidence to suggest the participation of immune system deregulation in MDS pathogenesis. Interleukin-32 (IL-32) is a newly described multifunctional cytokine reported as an important mediator in autoimmune and inflammatory disorders. In the present study, we reported the expression of IL32 and IL32 transcript variants (α, β, γ and δ) in peripheral blood CD3 + cells from healthy controls and MDS patients. Methods: CD3 + cells were isolated by immunomagnetic cell sorting from thirty-nine untreated MDS patients and twenty-nine healthy donors. Gene expression was evaluated by quantitative PCR. For statistical analysis, Mann-Whitney test, Kruskal-Wallis test with Dunns post test and Log-rank (Mantel-Cox) were used, as appropriate. A p value <0.05 was considered statistically significant.

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“…In addition, IL32 stimulates the production of vascular endothelial growth factor (VEGF) and thus has an indirect role in angiogenesis (24,25).…”

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confidence: 99%

Protein Expression and Genetic Variation of IL32 and Association with Colorectal Cancer in Swedish Patients

Shamoun

Kołodziej

Andersson

et al. 2018

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Interleukin-32 Increases Human Gastric Cancer Cell Invasion Associated with Tumor Progression and Metastasis

Cited by 94 publications

References 34 publications

Clinical significance of serum interleukin-29, interleukin-32, and tumor necrosis factor alpha levels in patients with gastric cancer

Clinical significance of serum interleukin-29, interleukin-32, and tumor necrosis factor alpha levels in patients with gastric cancer

IL32 expression in peripheral blood CD3+ cells from myelodysplastic syndromes patients

Protein Expression and Genetic Variation of IL32 and Association with Colorectal Cancer in Swedish Patients

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