Interleukin 36 gamma in psoriasis patients

Farag, Azza Gaber Antar; Marea, Alaa H.; Al-Sharaky, Dalia Rifaat; Bahat, Safaa M.Al

doi:10.1097/01.ewx.0000546356.40865.e4

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Symptoms of leprosy may appear within a year, but for some people, symptoms may take 20 years or more to occur, (Farag et al, 2022). House contacts with leprosy cases are at the highest risk, (Tió-Coma et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

The Flow of Social Environmental Determinants of Disabilities on Lepers in Tuban City

Rockmawati,

Aris Santjaka,

Lagiono

et al. 2023

JPK

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Background: Leprosy is a neglected tropical disease considered rare in most areas despite having a relatively high incidence in some countries. Objective: Analyze the flow of determinants of the social environment that can affect the occurrence of disability in lepers and their impacts. Method: Research using a qualitative approach. The research was conducted in Tuban Regency, East Java Province. The informant selection technique uses a purposeful sampling technique. Data analysis uses triangulation techniques. Results: The frequency of leprosy in Tuban Regency tended to decrease from 2014-2019. Leprosy distribution occurred in 18 sub-districts; Lepers were found every month in 2019 with various characteristics of lepers that cause the emergence of leprosy and disability in leprosy. The total number of informants in this study was seven informants. Determinants of disability in lepers include informant characteristics and social environment, including knowledge, contact history, family support, self-confidence, and impact. Conclusion: In this study, the social environment that most impact the occurrence of disability in lepers is the informant knowledge factor. Informant knowledge is influenced by education, a large network of friends, and technological literacy. Education will show the type of informant work, and the type of work will determine the income of the informant; income determines economic status. Economic status contributes to food intake, medication seeking, and the home's physical condition. The duration of leprosy treatment will affect the worsening of the disability if good self-care is not carried out and always use PPE when doing activities.

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Section: Resultsmentioning

confidence: 99%

The Flow of Social Environmental Determinants of Disabilities on Lepers in Tuban City

Rockmawati,

Aris Santjaka,

Lagiono

et al. 2023

JPK

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“…A retrospective immunohistochemical study of psoriatic lesions of 40 patients with psoriasis and matched controls demonstrated that IL-36γ was strongly expressed (in four or more layers) in the nuclei of suprabasal epidermal keratinocytes, while, in all controls, weak cytoplasmic expression was detected in the basal layer. Additionally, the elevated IL-36γ expression was significantly associated with psoriasis severity [ 41 ].…”

Section: Il-36 As a Central Node In Gpp Pathogenesismentioning

confidence: 99%

Role of Interleukin 36 in Generalised Pustular Psoriasis and Beyond

Sugiura

2022

Dermatol Ther (Heidelb)

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Generalised pustular psoriasis (GPP), a severe neutrophilic skin disease characterised by the sudden and widespread eruption of superficial sterile pustules, remains a challenging disease with limited treatment options. The recent discovery of genetic mutations associated with GPP and advances in understanding of the molecular mechanisms of autoinflammation have resulted in identification of key cytokines that drive the development and progression of GPP. Accumulating evidence demonstrates that interleukin (IL)-36 acts as a central node cytokine by orchestrating the hyperactivation of key pro-inflammatory cytokines and stimulating immune cells, including neutrophilic accumulations, a unique feature of GPP skin lesions. These findings are paving the way for the discovery and development of novel targeted GPP therapeutics that block the IL-36 pathway and neutralise the pathogenic immunologic mechanisms and pro-inflammatory cytokines. This article provides an overview of the current evidence that supports the role of IL-36 as a central node cytokine in GPP pathogenesis.

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Interleukin 36 gamma in psoriasis patients

Cited by 2 publications

References 21 publications

The Flow of Social Environmental Determinants of Disabilities on Lepers in Tuban City

The Flow of Social Environmental Determinants of Disabilities on Lepers in Tuban City

Role of Interleukin 36 in Generalised Pustular Psoriasis and Beyond

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