Interleukin-37 gene polymorphism and susceptibility to coronavirus disease 19 among Iraqi patients

Ahmed, Aeshah A.; Ad’hiah, Ali H.

doi:10.1016/j.mgene.2021.100989

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…Additionally, IL-37 was significantly correlated with vitamin D levels [ 231 ]. Second, they discovered that mutations of the IL37 genes are also associated with the susceptibility to the COVID-19 [ 232 ]. Accumulation data suggest the inflammatory role of IL-36 and protective features of the IL-37 and IL-38 in SARS-CoV-2 induced inflammation.…”

Section: The Pathogenesis Of Il-36 Il-37 and Il-38 In Covid-19mentioning

confidence: 99%

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

et al. 2022

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A global pandemic has erupted as a result of the new brand coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated with widespread mortality worldwide. The antiviral immune response is an imperative factor in confronting the recent coronavirus disease 2019 (COVID-19) infections. Meantime, cytokines recognize as crucial components in guiding the appropriate immune pathways in the restraining and eradication of the virus. Moreover, SARS-CoV-2 can induce uncontrolled inflammatory responses characterized by hyper-inflammatory cytokine production, which causes cytokine storm and acute respiratory distress syndrome (ARDS). As excessive inflammatory responses are contributed to the severe stage of the COVID-19 disease, therefore, the pro-inflammatory cytokines are regarded as the Achilles heel during COVID-19 infection. Among these cytokines, interleukin (IL-) 1 family cytokines (IL-1, IL-18, IL-33, IL-36, IL-37, and IL-38) appear to have a strong inflammatory role in severe COVID-19. Hence, understanding the underlying inflammatory mechanism of these cytokines during infection is critical for reducing the symptoms and severity of the disease. Here, the possible mechanisms and pathways involved in inflammatory immune responses are discussed.

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Section: The Pathogenesis Of Il-36 Il-37 and Il-38 In Covid-19mentioning

confidence: 99%

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

et al. 2022

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“…However, evidence suggests that rs3811047 is associated with susceptibility to PU, ankylosing spondylitis, RA, autoimmune thyroid diseases and Behcet's disease (Davarpanah et al., 2020; Lin et al., 2018; Özgüçlü et al., 2019; Tan et al., 2016). Interestingly, a similar study found a significant association between the two SNPs and susceptibility to COVID‐19 among Iraqi patients (Ahmed & Ad'hiah, 2022). In addition, we do not find the haplotypes associated with an increased risk for chronic HBV infection in this study, but the haplotype G‐C‐A‐T‐T‐A (in the order: rs3811042, rs3811043, rs2466449, rs3811045, rs3811046 and rs3811047) is associated with a 10.23‐fold increased risk of COVID‐19.…”

Section: Discussionmentioning

confidence: 89%

Correlation analysis of IL‐37 gene polymorphisms and susceptibility to chronic HBV infection among Han people in Central China

Cheng,

Sun,

Ouyang

et al. 2023

Int J Immunogenetics

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Hepatitis B virus (HBV) is responsible for various liver diseases, such as chronic hepatitis B (CHB), liver fibrosis, liver cirrhosis (LC) and hepatocellular carcinoma (HCC), which pose a significant threat to human health. An ineffective immune response to HBV can result in viral chronicity. Interleukin‐37 (IL‐37), an immunomodulator, is capable of inhibiting both innate and adaptive immune responses. It is believed that single nucleotide polymorphisms (SNPs) within the IL‐37 gene could contribute to the regulation of HBV clearance. Our aim to conduct this study was to investigate whether SNPs in the IL‐37 gene were associated with the risk of chronic HBV infection in adults. A total of 342 participants, consisting of 171 cases and 171 controls, were recruited for this study. Sanger sequencing was employed for genotyping six SNPs (rs3811042 G/A, rs3811043 G/C, rs2466449 A/G, rs3811045 C/T, rs3811046 T/G and rs3811047G/A). There was no significant difference in allele and genotype distribution between the two groups, and the constructed haplotypes were not found to be associated with the risk of chronic HBV infection. Our results revealed that there was no relationship between these six SNPs (rs3811042G/A, rs3811043G/C, rs2466449A/G, rs3811045C/T, rs3811046T/G and rs3811047G/A) in the IL‐37 gene and susceptibility to chronic HBV infection among Han people in Central China.

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“…Given the fact that high early IL-37 responses were accompanied with speedy recovery among hospitalized patients (earlier viral clearance, chest tomographic improvement, and cough relief) ( Table 1 ), the authors suggested that IL-37 administration may be used to maintain a balanced inflammatory response ( Li et al, 2021 ). Moreover, Ahmed and Ad’hiah (2021a) revealed the role of IL-37 in the virus-mediated pathogenesis. In a case-control study involving 200 patients, the sequencing of the IL37 gene (Gene ID: 27178) identified a couple of single nucleotide polymorphisms (SNPs) that were directly linked with the susceptibility to COVID-19.…”

Section: Correlation Between Interleukin 37 and Covid-19mentioning

confidence: 99%