Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk

Landi, Stefano; Bottari, Fabio; Gemignani, Federica; Gioia-Patricola, Lydie; Guinó, Elisabet; Osorio, Alfonso; de, Javier; Capellà, Gabriel; Canzian, Federico; Moreno, Vı́ctor

doi:10.1016/j.ejca.2006.10.024

Cited by 49 publications

(36 citation statements)

References 27 publications

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“…For IL-4, the main effect was not statistically significant in the complete dataset (OR 1.23, 95 % CI 0.81-1.86), but was significant in the colon cancer subgroup (Landi et al 2007). Our results have shown that individuals with a T allele in the rs2243250 SNP, located in the promoter region of IL-4, tended to have a lower DII.…”

Section: Discussionmentioning

confidence: 52%

“…The four selected SNPs of inflammatory genes [IL-4, IL-6, IL-8, and peroxisome proliferator-activated receptor-c (PPARG)] were the genes significantly associated with CRC risk in our previous studies in the main effects or in the subgroup analyses (Landi et al 2003(Landi et al , 2007. After DNA was extracted, genotyping was performed with the TaqMan technology using the protocol recommended by the supplier (Applied Biosystems, Foster City, CA, USA).…”

Section: Gene and Lifestyle Assessmentmentioning

confidence: 99%

“…Thus, patients with a history of chronic inflammatory bowel diseases have an increased risk of developing CRC (Laukoetter et al 2011), whereas habitual use of nonsteroidal anti-inflammatory drugs is associated with a lower CRC risk (Wang and DuBois 2013). Moreover, circulating inflammatory biomarkers, such as C-reactive protein (CRP) (Aleksandrova et al 2010), cytokines, chemokines, and cell adhesion molecules (McClellan et al 2012;Song et al 2013), and some genes related to pro-inflammation (Landi et al 2003(Landi et al , 2007 tended to be associated with a higher CRC risk. Diet plays a crucial role in the etiology of CRC (World Research Cancer Fund and American Institute for Cancer Research 2007), although there is little evidence of the proinflammatory and anti-inflammatory effects of the overall diet on CRC risk (Shivappa et al 2014a).…”

Section: Introductionmentioning

confidence: 99%

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Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

et al. 2014

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Chronic inflammation is an important factor in colorectal carcinogenesis. However, evidence on the effect of pro-inflammatory and anti-inflammatory foods and nutrients is scarce. Moreover, there are few studies focusing on diet-gene interactions on inflammation and colorectal cancer (CRC). This study was designed to investigate the association between the novel dietary inflammatory index (DII) and CRC and its potential interaction with polymorphisms in inflammatory genes. Data from the Bellvitge Colorectal Cancer Study, a case-control study (424 cases with incident colorectal cancer and 401 hospital-based controls), were used. The DII score for each participant was obtained by multiplying intakes of dietary components from a validated dietary history questionnaire by literature-based dietary inflammatory weights that reflected the inflammatory potential of components. Data from four important single nucleotide polymorphisms located in genes thought to be important in inflammationassociated CRC: i.e., interleukin (IL)-4, IL-6, IL-8, and peroxisome proliferator-activated receptor-c (PPARG) were analyzed. A direct association was observed between DII score and CRC risk (OR Q4 vs. Q1 1.65, 95 % CI 1.05-2.60, and P trend 0.011). A stronger association was found with colon cancer risk (OR Q4 vs. Q1 2.24, 95 % CI 1.33-3.77, and P trend 0.002) than rectal cancer risk (OR Q4 vs. Q1 1.12, 95 % CI 0.61-2.06, and P trend 0.37). DII score was inversely correlated with SNP rs2243250 in IL-4 among controls, and an interaction was observed with CRC risk. Neither correlation nor interaction was detected for other inflammatory genes. Overall, high-DII diets are associated with increased risk of CRC, particularly for colon cancer, suggesting that dietary-mediated inflammation plays an important role in colorectal carcinogenesis.Electronic supplementary material The online version of this article

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Section: Discussionmentioning

confidence: 52%

Section: Gene and Lifestyle Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

et al. 2014

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“…In a Japanese study on sporadic renal cell carcinoma, the IL4R I75V polymorphism was described as a useful genetic marker for assessing the risk of the tumor development and progression [24]. No increased risk for colorectal cancer but an increased risk for cervical cancer was found for the IL4R V75 allele [25,26]. Cervical cancer is related to human papillomavirus infection and Th1 immune responses are essential for viral clearance.…”

Section: Discussionmentioning

confidence: 99%

Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial

et al. 2009

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Background: Recently published data indicate that host germline variations in immune genes can influence the outcome of lymphoma patients. Interleukin (IL)-4 and IL13 are crucial immune factors and may influence the course of the disease. Both cytokines signal through the interleukin-4 receptor (IL4R). Therefore, we investigated whether polymorphisms of IL4, IL13 and IL4R genes could predict the outcome of diffuse large B-cell lymphoma (DLBCL) patients. Methods:In 228 DLBCL samples of the German High-Grade Non-Hodgkin's Lymphoma Study Group, the polymorphisms of IL4 (-524CT, rs2243250), IL13 (-1069CT, rs1800925) and IL4R (I75V, rs1805010; S503P, rs1805015; Q576R, rs1801275) were analyzed and the soluble interleukin-4 receptor (sIL4R) serum level was measured before the start of chemotherapy.Results: Patients harboring IL4R V75 (IL4R I75V-AG and IL4R I75V-GG ) had shorter overall survival (OS) (P = 0.044) and event-free survival (EFS) (P = 0.056) periods compared with I75 carriers (IL4R I75V-AA ). Multivariate analysis adjusted to the International Prognostic Index revealed a relative risk of 1.9 for carriers of the IL4R V75 (P = 0.011) in relation to OS. DLBCL patients homozygous for the IL4R I75 and low sIL4R serum levels have the most favorable OS and EFS.Conclusions: These data support the role for host germline gene variations of immunologically important factors like the IL4R I75V gene variation to predict the survival in DLBCL patients.

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“…In particular, evidence suggests that SOCS-1 acts as a critical regulator of the IFN-γ (Piganis et al, 2011) and IL-4 (Losman et al, 1999) signaling pathways, which are both involved in the pathogenesis of CC (Landi et al, 2007;Slattery et al, 2011). A functional SOCS-1 promoter polymorphism (-1478CA>del) has been shown to increase SOCS-1 transcription in vitro (Harada et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The SOCS-1 -1478CA/del Polymorphism is not Associated with Colorectal Cancer or Age at Onset in Turkish Subjects

Hartavi

Kurt²,

Oral³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Suppressor of cytokine signaling (SOCS)-1 acts as a key regulator of many cytokine signaling pathways and its abnormal expression has been identified in several human malignancies, suggesting potential roles in carcinogenesis. The aim of this study was to investigate any association between the functional SOCS-1 -1478CA>del polymorphism and colorectal cancer (CC) as well as age at onset in a Turkish clinical sample. Materials and Methods: A total of 122 subjects were enrolled in this case-control study (70 CC cases and 52 controls). The SOCS-1 -1478CA>del polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The odds ratio of the del allele for CC relative to the CA allele was not significantly different between the groups (OR=0.71, 95% CI=0.41-1.22, p=0.27). This result did not change after adjustment for age and sex on multivariable regression analysis (OR=0.84, 95% CI=0.59-1.34, p=0.53). When the SOCS-1 -1478CA>del polymorphism was analyzed among CC patients in relation to the age at disease onset, we found no significant differences between subjects with the del/del, CA/del, and CA/CA genotypes. Conclusions: The results of our study did not point towards a major role of the SOCS-1 -1478CA>del polymorphism in the pathogenesis of CC in Turkish subjects.

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Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk

Cited by 49 publications

References 27 publications

Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial

The SOCS-1 -1478CA/del Polymorphism is not Associated with Colorectal Cancer or Age at Onset in Turkish Subjects

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