Interleukin-6: A promising disease severity index for dengue virus infection

Kanwal, Fariha; Lu, Changrui; Qadri, Ishtiaq; Sohail, Muhammad; Farooqi, Zia-ur-Rahman

doi:10.12980/apjtd.7.2017d6-461

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…Moreover, the increased IL‐17 levels, were also associated with clinical manifestations including bleeding, pleural effusion, convulsions, and respiratory distress in dengue patients, 38 while in another study, interleukins IL‐17, IL‐4, and IL‐9 were significantly increased in DHF and DSS patients in comparison to DF subjects 39 . Kanwal et al carried out a study on 60 dengue‐infected subjects and demonstrated a correlation between serum IL‐6 levels and dengue complication DHF 40 . The CRP is a sensitive biomarker of inflammation and might be an early predictor of dengue severity.…”

Section: Discussionmentioning

confidence: 96%

Elevated serum PAR‐1 levels as an emerging biomarker of inflammation to predict the dengue infection severity

Sibia

Sood

Subedi

et al. 2022

Journal of Medical Virology

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The present study was designed to check the serum levels of protease‐activated receptor (PAR‐1) in patients during different phases of dengue severity. Moreover, a correlation between serum PAR‐1 levels and hematological parameters, inflammatory cytokine levels, and liver functional changes was also determined. Based on the World Health Organization criteria, the study population was divided into: nonsevere dengue fever (DF; n = 30), severe dengue hemorrhagic fever (DHF; n = 19), and severe dengue shock syndrome (DSS; n = 11). The platelet count (PLT) and hematocrit (HCT) were analyzed using an automated hematology analyzer and liver function enzymes aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphate (ALP), bilirubin were checked by auto‐analyzer using diagnostic kits. Moreover, the levels of inflammatory mediators C‐reactive protein (CRP), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), interleukin‐17 (IL‐17), and PAR‐1 were determined using respective ELISA kits. The HCT levels were elevated and platelet count decreased significantly during dengue complications (DHF and DSS) compared to the DF patients, while the levels of liver functional biomarkers AST, ALT, ALP, and bilirubin remained elevated in DHF and DSS groups than in the corresponding DF group. Similarly, the inflammatory cytokine levels of CRP, TNF‐α, IL‐6, and IL‐17 in DHF and DSS subjects were markedly increased when observed against DF subjects. Notably, the PAR‐1 levels were significantly elevated in DHF and DSS groups than in the DF group and positively correlated with changes in HCT levels, inflammatory biomarkers, and liver enzymes. Our findings conclude that PAR‐1 levels persistently increased with the severity of the dengue infection and are strongly associated with various clinical manifestations. Thus, PAR‐1 levels can be used as a diagnostic marker for assessing dengue severity.

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Section: Discussionmentioning

confidence: 96%

Elevated serum PAR‐1 levels as an emerging biomarker of inflammation to predict the dengue infection severity

Sibia

Sood

Subedi

et al. 2022

Journal of Medical Virology

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“…Estes últimos indicam que o aumento da IL-6 durante certas infecções virais pode promover a sobrevivência do vírus e/ ou exacerbação da doença clínica (HOU et al, 2014;PACHECO et al, 2015;ROLLENHAGEN;ASIN, 2011;VELAZQUEZ-SALINAS et al, 2018;WATTRANG et al, 2003) Em infecções pelo DENV, a presença de altos níveis de IL-6 no soro foi reportada em diversos estudos, sendo geralmente correlacionada com o acometimento de DHF (CHAKRAVARTI; KUMARIA, 2006;CHATURVEDI et al, 2000;HOBER et al, 1993;JUFFRIE et al, 2001;KANWAL et al, 2017;PINTO et al, 1999;PRIYADARSHINI et al, 2010 RAAB-TRAUB, PERCARIO et al, 2003;SEN et al, 2012;TACKE et al, 2011;WARIS;HUH;SIDDIQUI, 2001). Da mesma forma, infecções pelo DENV já demonstram levar a um aumento da expressão da via JAK/STAT3, através de mecanismos dependentes de IFN (HO et al, 2005;TSAI et al, 2011).…”

Section: Discussão Dos Resultadosunclassified

Sinalização e metabolismo celulares durante a diferenciação de linfócitos B humanos em secretores de anticorpos na presença do vírus da Dengue >i<in vitro>/i< e em pacientes com Dengue

Bonezi¹

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In vitro analysis of VEGF-mediated endothelial permeability and the potential therapeutic role of Anti-VEGF in severe dengue

Lim,

Gan,

Ong

et al. 2024

Biochemistry and Biophysics Reports

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Interleukin-6: A promising disease severity index for dengue virus infection

Cited by 6 publications

References 27 publications

Elevated serum PAR‐1 levels as an emerging biomarker of inflammation to predict the dengue infection severity

Elevated serum PAR‐1 levels as an emerging biomarker of inflammation to predict the dengue infection severity

Sinalização e metabolismo celulares durante a diferenciação de linfócitos B humanos em secretores de anticorpos na presença do vírus da Dengue >i<in vitro>/i< e em pacientes com Dengue

In vitro analysis of VEGF-mediated endothelial permeability and the potential therapeutic role of Anti-VEGF in severe dengue

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