Interleukin 6 and depression in patients affected by Covid-19

García, Antonio Serrano; Mateo, Judith Montánchez; Pato, Clara Margarita Franch; Martínez, Rocío Gómez; Vázquez, Paula García; Rodríguez, Isabel González

doi:10.1016/j.medcle.2020.11.013

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…The most investigated inflammatory markers were readily available routine biomarkers of inflammation, especially CRP [ 10 , 13 , 26 , 34 , 98 , 110 – 115 ] and neutrophil/lymphocyte ratio (NLR) [ 10 , 13 , 110 , 112 , 114 – 117 ]. Among cytokines, the most investigated were IL-6 [ 34 , 111 – 115 , 118 , 119 ], IL-10 [ 34 , 111 , 112 , 120 ], and TNF-α [ 111 , 112 , 118 , 120 ]. Finally, two studies investigated T-cell subpopulations [ 111 , 120 ].…”

Section: Neurobiology Of Post-covid-19 Depressive Symptomsmentioning

confidence: 99%

“…Finally, two studies investigated T-cell subpopulations [ 111 , 120 ]. Among the included studies, 13 studies [ 10 , 13 , 26 , 34 , 98 , 111 – 113 , 115 – 117 , 119 , 120 ] found a significant association between inflammatory markers and COVID-19-related depressive symptoms, while three studies did not find any statistical association [ 110 , 114 , 118 ]. Specifically, post-COVID-19 depressive symptoms were found to be associated with NLR in four studies [ 112 , 115 – 117 ], with CRP in four studies [ 34 , 98 , 113 , 115 ], with systemic inflammation index (SII) in three studies [ 10 , 13 , 26 ], with the neutrophil count in two studies [ 115 , 117 ], and with IL-6 in two studies [ 34 , 113 ].…”

Section: Neurobiology Of Post-covid-19 Depressive Symptomsmentioning

confidence: 99%

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Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment

et al. 2022

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The Coronavirus Disease 2019 (COVID-19) pandemic is still spreading worldwide over 2 years since its outbreak. The psychopathological implications in COVID-19 survivors such as depression, anxiety, and cognitive impairments are now recognized as primary symptoms of the “post-acute COVID-19 syndrome.” Depressive psychopathology was reported in around 35% of patients at short, medium, and long-term follow-up after the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. Post-COVID-19 depressive symptoms are known to increase fatigue and affect neurocognitive functioning, sleep, quality of life, and global functioning in COVID-19 survivors. The psychopathological mechanisms underlying post-COVID-19 depressive symptoms are mainly related to the inflammation triggered by the peripheral immune-inflammatory response to the viral infection and to the persistent psychological burden during and after infection. The large number of SARS-CoV-2-infected patients and the high prevalence of post-COVID-19 depressive symptoms may significantly increase the pool of people suffering from depressive disorders. Therefore, it is essential to screen, diagnose, treat, and monitor COVID-19 survivors’ psychopathology to counteract the depression disease burden and related years of life lived with disability. This paper reviews the current literature in order to synthesize the available evidence regarding epidemiology, clinical features, neurobiological underpinning, and pharmacological treatment of post-COVID-19 depressive symptoms.

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Section: Neurobiology Of Post-covid-19 Depressive Symptomsmentioning

confidence: 99%

Section: Neurobiology Of Post-covid-19 Depressive Symptomsmentioning

confidence: 99%

Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment

et al. 2022

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“…38 Some data have suggested that the degree of inflammation in COVID-19 is correlated with the extent of depressive symptoms, 39 although this has not always been replicated. 40 It remains to be established whether cytokines play a causal role in depressive illness in COVID-19 and other inflammatory conditions or whether they simply represent epiphenomena without major significance (or, more likely, that the bidirectional relationship is complicated and not yet fully understood).…”

Section: Neurobiology Of Covid-19mentioning

confidence: 99%