Interleukin-6 and interleukin-10 gene polymorphism, endothelial dysfunction, and postoperative prognosis in patients with peripheral arterial disease

Stoica, Adina; Stoica, Emanuel; Constantinescu, Ileana; Uscătescu, Valentina; Ginghină, Carmen

doi:10.1016/j.jvs.2010.01.088

Cited by 28 publications

(15 citation statements)

References 30 publications

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“…The combined analysis showed the formation of seven haplotypes, of which ATA, ACC, and GCC had been previously identified in leprosy patients by Franceschi et al (9). Trajkov et al (32) found the haplotype ATC to have a positive association with an individual's susceptibility to tuberculosis, while the other haplotypes were observed only in the study of diseases not related to leprosy, such as the GTA haplotype, found by Wu et al (33), in healthy individuals susceptible to silicosis; ACA, which was observed by Lung et al (34) to be associated with schizophrenia; and GCA, in studies on peripheral arterial disease (35) and diabetes (36). In the present study, no significant difference was found for the haplotypes ACC and GCC despite their high frequency (Table 2), as previously suggested by Ates et al (12).…”

Section: Discussionmentioning

confidence: 98%

Haplotypes of theIL10Gene as Potential Protection Factors in Leprosy Patients

Garcia

Alencar

Pinto

et al. 2013

Clin. Vaccine Immunol.

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Section: Discussionmentioning

confidence: 98%

Haplotypes of theIL10Gene as Potential Protection Factors in Leprosy Patients

Garcia

Alencar

Pinto

et al. 2013

Clin. Vaccine Immunol.

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“…One other study in an Eastern Finland population showed that IL-10 plasma concentration independently correlates with cardioembolic high-risk sources, suggesting its usefulness in improving diagnosis of stroke etiology (81). Lastly, in Caucasian patients with peripheral artery disease receiving elective revascularization, the IL-10ATA haplotypes that are associated with lower serum IL-10 levels correlate with a high risk for postoperative cardiovascular events (73). …”

Section: Ischemic Strokementioning

confidence: 99%

Role of Interleukin-10 in Acute Brain Injuries

et al. 2017

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Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to brain injury, where it facilitates the resolution of inflammatory cascades, which if prolonged causes secondary brain damage. Here, we comprehensively review the current knowledge regarding the role of IL-10 in modulating outcomes following acute brain injury, including traumatic brain injury (TBI) and the various stroke subtypes. The vascular endothelium is closely tied to the pathophysiology of these neurological disorders and research has demonstrated clear vascular endothelial protective properties for IL-10. In vitro and in vivo models of ischemic stroke have convincingly directly and indirectly shown IL-10-mediated neuroprotection; although clinically, the role of IL-10 in predicting risk and outcomes is less clear. Comparatively, conclusive studies investigating the contribution of IL-10 in subarachnoid hemorrhage are lacking. Weak indirect evidence supporting the protective role of IL-10 in preclinical models of intracerebral hemorrhage exists; however, in the limited number of clinical studies, higher IL-10 levels seen post-ictus have been associated with worse outcomes. Similarly, preclinical TBI models have suggested a neuroprotective role for IL-10; although, controversy exists among the several clinical studies. In summary, while IL-10 is consistently elevated following acute brain injury, the effect of IL-10 appears to be pathology dependent, and preclinical and clinical studies often paradoxically yield opposite results. The pronounced and potent effects of IL-10 in the resolution of inflammation and inconsistency in the literature regarding the contribution of IL-10 in the setting of acute brain injury warrant further rigorously controlled and targeted investigation.

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“…[24][25][26][27][28] However, despite being a common disease, the etiology of noninherited vascular anomalies is still poorly investigated. Recently, Limaye et al 17 was the first to identify eight somatic mutations in exon 17 of the TEK gene in 49.1% of patients with common sporadic venous malformation in Europe.…”

Section: Discussionmentioning

confidence: 99%