Interleukin-6 and Interleukin-10 Gene Polymorphisms in Patients with Chronic Periodontitis and Response to Treatment after 3 Years

Abstract

Objective The aim of this study was to investigate whether genetic susceptibility to chronic periodontitis, conferred by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele, influences the outcomes following a non-surgical periodontal therapy (NSPT)over a long period of time. Material and methods Thirty-seven chronic periodontitis patients were divided into two groups according to genotype as susceptible (SCP) and non-susceptible (NSCP). All subjects were clinically evaluated at baseline and 3 years following NSPT. Blood samples were collected at baseline from the individuals who fulfilled the inclusion criteria. All participants received NSPT from a single periodontist who was blind to the genotype status of each patient. A statistical analysis was performed by comparing the variables between groups using the Mann-Whitney U test and between baseline and 3 years for each group using the Wilcoxon test. Results The mean age of the population was estimated to be 47.68±8.64 years and it included 51.4% females, 48.6% smokers, and 45.9% alcohol consumers. Following a genetic analysis, 70.3% of patients were homozygous carriers of the IL-6 -572G (IL-6 SCP), and 46.0% of them were carriers of the IL-10 -592A allele (IL-10 SCP). NSPT reduced all studied parameters (probing depth, attachment loss, bleeding on probing, percentage of sites with 4-6mm and ≥7mm pocket depth and attachment loss) to all participants, but the treatment outcome was not associated with the genotype. The SCP and NSCP individuals showed similar clinical parameters at baseline and at 3 years. Conclusions Within the limitations of this 3-year prospective cohort study in Caucasians diagnosed with chronic periodontitis, individuals susceptible to periodontal disease as determined by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele showed similar treatment outcome following NSPT.

The Role of Interleukin 6 in Periodontitis and Its Complications

“…Several experimental studies have measured the IL-6 values in serum as well as in GCF to prove the effectiveness of periodontitis therapy. In addition to clinical control parameters, diagnostic IL-6 values help clinicians to understand the pathophysiology of a patient's individual disease, and the probability of regression can be determined with great accuracy [91][92][93]. When clinical parameters are improved and the levels of cytokines are also reduced, the probability of an effective cure is very high.…”

Dental Status and Periodontal Health of Patients with Phenylketonuria in Latvia

“…Bacteria are the main etiological factor of periodontal disease; however, the severity of periodontal lesions can be influenced by numerous environmental factors and acquired diseases. There can also be a certain degree of genetic predisposition to periodontal disease ( 7 , 8 ). In most cases, incorrect and/or irregular tooth brushing coupled with a failure to use interdental cleaning products is the direct cause of periodontal disease development since perfect conditions for bacteria to flourish in persistent dental plaque and calculus are thus created ( 9 , 10 ).…”