Interleukin-6 as a diagnostic marker for infection in critically ill patients: A systematic review and meta-analysis

Iwase, Shinya; Nakada, Taka‐aki; Hattori, Noriyuki; Takahashi, Waka; Takahashi, Nozomi; Aizimu, Tuerxun; Yoshida, Masahiro; Morizane, Toshio; Oda, Shigeto

doi:10.1016/j.ajem.2018.05.040

Cited by 35 publications

(29 citation statements)

References 28 publications

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“…Similarly, interferon gamma-induced protein 10 (IP-10) is correlated with patient viral load, whereas monocyte-chemotactic protein 3 (MCP3) is associated with loss of lung function (PaO 2 /FaO 2 ratio), lung injury (Murray Score) and fatal outcome (40). Systemic inflammation was also observed in fatal cases of H1N1, with high IL-6 and IP-10 concentrations in the lungs, associated with massive infiltration of immune cells in the lung (41), also reported in severe or fatal forms of avian H5N1 and H7N9 pulmonary infection (42,43).…”

Section: Recent Progress In Immune Control Of Covid-19 Pathogenesismentioning

confidence: 99%

Cell-Mediated Immune Responses to COVID-19 Infection

et al. 2020

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An unprecedented outbreak of pneumonia caused by a novel coronavirus (CoV), subsequently termed COVID-19 by the World Health Organization, emerged in Wuhan City (China) in December 2019. Despite rigorous containment and quarantine efforts, the incidence of COVID-19 continues to expand, causing explosive outbreaks in more than 160 countries with waves of morbidity and fatality, leading to significant public health problems. In the past 20 years, two additional epidemics caused by CoVs have occurred: severe acute respiratory syndrome-CoV, which has caused a large-scale epidemic in China and 24 other countries; and respiratory syndrome-CoV of the Middle East in Saudi Arabia, which continues to cause sporadic cases. All of these viruses affect the lower respiratory tract and manifest as pneumonia in humans, but the novel SARS-Cov-2 appears to be more contagious and has spread more rapidly worldwide. This mini-review focuses on the cellular immune response to COVID-19 in human subjects, compared to other clinically relevant coronaviruses to evaluate its role in the control of infection and pathogenesis and accelerate the development of a preventive vaccine or immune therapies.

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Section: Recent Progress In Immune Control Of Covid-19 Pathogenesismentioning

confidence: 99%

Cell-Mediated Immune Responses to COVID-19 Infection

et al. 2020

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“…IL-6 also regulates B cell proliferation and differentiation and induces T cell differentiation [80][81][82]. Although IL-6 has been proposed to be involved in the repair of lung injury in the mouse model of influenza A H1N1 virus [83], it contributes to the pathogenesis of inflammatory or autoimmunity diseases [84,85], and excessive production of IL-6 leads to serious disease progression in viral infection [86,87].…”

Section: Cytokine Stormmentioning

confidence: 99%

Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications

Zhu

2020

Pharmacological Research

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Coronavirus Disease 2019 (COVID-19) has sparked a global pandemic, affecting more than 4 million people worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute lung injury (ALI) and even acute respiratory distress syndrome (ARDS); with a fatality of 7.0 %. Accumulating evidence suggested that the progression of COVID-19 is associated with lymphopenia and excessive inflammation, and a subset of severe cases might exhibit cytokine storm triggered by secondary hemophagocytic lymphohistiocytosis (sHLH). Furthermore, secondary bacterial infection may contribute to the exacerbation of COVID-19. We recommend using both IL-10 and IL-6 as the indicators of cytokine storm, and monitoring the elevation of procalcitonin (PCT) as an alert for initiating antibacterial agents. Understanding the dynamic progression of SARS-CoV-2 infection is crucial to determine an effective treatment strategy to reduce the rising mortality of this global pandemic.

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“…Shimazui et al (22) concluded that serum IL-6 was a more accurate predictor of the severity of organ dysfunction in critically ill patients than PCT or CRP, and rose more rapidly after the insult, reaching its peak earlier than SOFA score. We f o u n d a n i n c r e a s e d r a t e o f n o n -s u r v i v o r s (12,23,24). Our findings show that IL-2, IL-6, IL-8, TNF-α, and to a lesser extent PCT, are of crucial importance in the outcomes of critically ill surgical patients.…”

Section: Discussionmentioning

confidence: 60%

The predictive prognostic values of serum interleukin-2, interleukin-6, interleukin-8, tumor necrosis factor-α, and procalcitonin in surgical intensive care unit patients

Yan¹,

Hu²,

Wang³

et al. 2021

Ann Transl Med

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Background: The pathophysiological roles of serum cytokine levels in critically ill surgical patients has yet to be determined. This study aimed to determine the predictive prognostic values of serum interleukin IL-2, IL-6, IL-8, tumor necrosis factor-α (TNF-α), and procalcitonin (PCT) in surgical intensive care unit (ICU) patients.Methods: Cytokine concentrations were measured with an IMMULITE 1000 Immunoassay System

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Interleukin-6 as a diagnostic marker for infection in critically ill patients: A systematic review and meta-analysis

Cited by 35 publications

References 28 publications

Cell-Mediated Immune Responses to COVID-19 Infection

Cell-Mediated Immune Responses to COVID-19 Infection

Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications

The predictive prognostic values of serum interleukin-2, interleukin-6, interleukin-8, tumor necrosis factor-α, and procalcitonin in surgical intensive care unit patients

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