Interleukin 6 Strongly Correlates with Malnutrition Inflammation Score and it is Strong Predictor for Mortality in Hemodialysis Patients

Th, Thiagarajan; avan,; Abraham, Georgi; Soundararajan, P.; rasekaran,

doi:10.15406/unoaj.2015.02.00030

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Similar results were also reported by Kaizu et where the average of IL-6 was 11.7 ± 2.8 pg/ml, 16.12 ± 34.1 pg/ml, and 45.2 ± 3.9 pg/ml [18], [22], [23]. Elevated of IL-6 can be caused by hypertension, adipocytes, insulin resistance, excess fluid, persistent infections, and dialysis procedures such as using bio incompatible membranes, non-sterile dialysis techniques, and back filtration [24], [25]. Several studies have shown that IL-6 do not increase during the hemodialysis process but rather than increase in 2 h after completion of hemodialysis [18], [25].…”

Section: Discussionmentioning

confidence: 99%

The Correlation of Interleukin-6, Malnutrition Inflammation Score and Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

Palar

Honoris

2022

Open Access Maced J Med Sci

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Introduction: Chronic kidney disease (CKD) patients undergoing routine hemodialysis (HD) have a high prevalence of protein-energy malnutrition (PEM) and inflammation. The combination of inflammation and PEM is associated with cardiovascular disease and poor outcomes. Interleukin-6 (IL-6) is an inflammatory factor that runs parallel to endothelial damage and is closely related to the nutritional status of CKD HD patients. The tool to assess nutrition status is Malnutrition Inflammation Score (MIS) and to assess endothelial damage is Asymmetric Dimethylarginine (ADMA). It is currently unclear whether there is a correlation between inflammation, malnutrition, and endothelial dysfunction. Therefore the aim of this study is to determine the correlation between IL-6, MIS and ADMA in CKD HD patients. Methods: A cross-sectional design with analytic observational study was conducted on end stage renal disease patient who undergo routine hemodialysis for at least 2 years with the duration of hemodialysis is 4-5 hours and at least twice per week. IL-6 was examined by kit (ELISA) and ADMA using LC-MS/MS at a certified laboratory in Manado city. History taking and physical examination were used to calculate MIS. Data analysis was done using SPSS version 22. Results: There were 30 participants consisting of 22 men (72%) and 8 women (28%). The median age of the subjects was 56.50 years. There was a statistically significant positive correlation between IL-6 and ADMA (r = 0.440, p = 0.015), MIS and ADMA (r = 0.378, p = 0.039), and IL-6 and MIS (r = 0.682, p = 0.0001). Conclusion: There was a significant correlation between IL-6, MIS and ADMA.

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Section: Discussionmentioning

confidence: 99%

The Correlation of Interleukin-6, Malnutrition Inflammation Score and Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

Palar

Honoris

2022

Open Access Maced J Med Sci

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“…The immune system can be express in two grades; cellular and humeral immunity , cellular immunity composed of (T cell) and (Cytokines) , while the humeral immunity composed of ( B cell) which immunoglobulin [7] . (IL-6) is one of the main of acute phase response, which is noted high in patients with end-stage dialysis, and is also is powerful predictor of disease outcome [8] , as well as plays an important role in the relationship between inflammation, malnutrition, and cardiovascular disease (CVD) in patients undergoing hemodialysis (HD) [9] . (IL-18) is produced when the renal tubules damaged [10] , also may be used as a marker for the diagnosis of dystrophy function loss in renal dysfunction patients [11] .…”

Section: Introductionmentioning

confidence: 99%

Detection Levels of Cytokines (IL-6 and IL-18) and Microbial Parameters in Patients with Renal Failure in Diyala Province

Wasan A. Wahab Alsiadi,

Alaa Mohammed Albayati,

Ban Talib Elhaboby

2021

Indian Journal of Forensic Medicine & Toxicology

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Current study was conducted in Diyala province for kidney failure patients ( Ibn Sina Center ) for dialysis in Baqubah teaching hospital and started from beginning August 2016 to end April 2017. A total 100 blood sample had from kidney failure patients, has been the number males 61 and females 39 with age range (10 -88) years and collected 50 of blood sample from oculary healthy individuals act as a control group , has been the number males 25 and females 25 with age range 10 -88 years . By (ELISA) technique detection immunological parameters (IL-6 , IL-18) , and (SRID) for detection microbial parameters (HBV, CMV , T. gondii, HCV) . Result of study expressed that the incidence of disease rate among males 61% more than females 39% with no significant different (P>0.05), also highest rate disease in both age groups (31-50, 51-70) years , while lowest rate disease the age range (10-30 , >70) years recorded with significance different) P <0.05(. So, high levels of ( IL-18) for patients than to control with significance different between study groups (P <0.05), while (IL-6) was raised in patients compared to control. Also, result showed positivity of ( HBV, CMV , T. gondii, HCV ) in patients was (8% , 13%, 10%, 25% ) respectively with high significant different (P<0.05). Conclusions of current study showed male more than female, age period >70 and 51-17 year recorded highest percentage infection ,high levels of immunological (IL-6 and IL-18) in renal dialysis patients, as well as to some microbial infected patients with kidney failure. The aim of study is detection levels of cytokines (IL-6 and IL-18) and some microbial infection in patients with renal failure.

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“…This suggestion gave way to development of modified NUTRIC in which IL-6 is not included in the score [15], and most studies have excluded IL-6 [16][17][18]. However, there is abundant evidence suggesting that IL-6 is strongly correlated with malnutrition inflammation in hemodialysis patients [19,20], patients with lung cancer [21], patients with latent tuberculosis infection [22], and end stage renal disease patients [23]. Therefore, IL-6 can be considered as an important biomarker which cannot be easily ignored in patients hospitalized in ICU.…”

Section: Introductionmentioning

confidence: 99%

The relation between malnutrition screening tool (NUTRIC) score and serum pro- and anti-inflammatory cytokines levels and some nutritional parameters in patients with traumatic head injury in Sulaimani

Ezzaddin¹

2021

PJMHS

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Background: Research has provided evidence that malnutrition screening tool (NUTRIC) score has a relation with interleukin-6 but not with other cytokines. In addition, the relation between malnutrition screening tool (NUTRIC) score and some nutritional parameters has not yet been studied in traumatic head injured patients. Therefore, the aim of the current study is examining the relation between malnutrition screening tool (NUTRIC) score and serum pro- and anti-inflammatory cytokines levels and some nutritional parameters in patients with traumatic head injury in the intensive care unit (ICU) of General Teaching Hospital in Sulaimani, the Kurdistan Region of Iraq in 2016-17. Methods: Using appropriate methods and tools, the patients’ (NUTRIC) score, mid-upper arm circumference (MUAC), disease severity and organ dysfunction, concentration level of serum cytokines (IL-6) were assessed within 24 hours after admission. All of the mentioned measurements except the serum interleukin were also assessed on days 6 and 13 of staying in ICU. Afterwards, in order to examine the relationship between the study’s variables, the collected data were analyzed using Mann-Whitney U test through SPSS 22.0. Results: The results of data analysis using Mann-Whitney U and independent samples T-tests revealed that there was a significant relation between malnutrition screening tool (NUTRIC) score and the studied interleukin (IL-6) within 24 hours after ICU admission. Other studied variables that had a significant association with the patients’ (NUTRIC) score within 24 hours after ICU admission were APACHE II score, SOFA score, and MUAC, this significant association has been seen on days 6 and 13 after ICU admission between malnutrition screening tool (NUTRIC) score and serum cytokines (IL-6) APACHE II, and SOFA scores. Conclusion: The results of the present study revealed that pro-inflammatory cytokines (IL-6) along with other factors such as APACHE II and SOFA had significantly higher among patients with risk of malnutrition. Keywords: pro-inflammatory cytokines, traumatic head injury (THI), nutritional score

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Interleukin 6 Strongly Correlates with Malnutrition Inflammation Score and it is Strong Predictor for Mortality in Hemodialysis Patients

Cited by 5 publications

References 13 publications

The Correlation of Interleukin-6, Malnutrition Inflammation Score and Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

The Correlation of Interleukin-6, Malnutrition Inflammation Score and Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

Detection Levels of Cytokines (IL-6 and IL-18) and Microbial Parameters in Patients with Renal Failure in Diyala Province

The relation between malnutrition screening tool (NUTRIC) score and serum pro- and anti-inflammatory cytokines levels and some nutritional parameters in patients with traumatic head injury in Sulaimani

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