Interleukin-8 gene expression by human dental pulp fibroblast in cultures stimulated with Prevotella intermedia lipopolysaccharide

Pulp capping materials exert an effect on the secretion of IL-1β and IL-8 by migrating human neutrophils

“…Among the inflammatory cytokines, IL-8 and IL-1β have already been found in the dental pulp. [10][11][12][13][14][15][16][17] In fact, IL8, whose production is generally induced by bacteria, is one of the most important chemotactic cytokines. This cytokine is responsible for recruiting neutrophils, a process required to induce acute inflammation, and is also involved in determining the duration of the inflammatory process.…”

Roles of dental pulp fibroblasts in the recognition of bacterium-related factors and subsequent development of pulpitis

“…Dental pulp cells, especially dental pulp fibroblasts, are known to produce various inflammatory mediators, such as IL-8, IL-6 and vascular endothelial growth factor (VEGF), in response to the components of caries-related bacteria, prior to the discovery and establishment of the innate immune system feature that PRRs including TLRs recognize various PAMPs [29,31,32,58]. TLR2, TLR3, TLR4 and TLR5 expressions have been determined in dental pulp fibroblasts and their specific agonists can induce TLR-mediated inflammatory signals [54,55,59,60], although immunohistological detection of TLRs was not clear in the fibroblasts of dental pulp tissues [49,52].…”

“…With the development of exposure to bacterial components, partial destruction of the odontoblast layer along with severe damage or death of odontoblasts can be observed, and the underlying dental pulp cells including fibroblasts and undifferentiated mesenchymal or stem cells in the cell-rich zone are activated to participate in the host response and initiate reparative dentin formation [26][27][28]. Thus, the dental pulp cells, a major cell type in the dental pulp, play a crucial role in maintaining the structural integrity of connective tissues, and they also have capacity to produce pro-inflammatory cytokines and express adhesion molecules in response to pathogen-associated molecular patterns (PAMPs), which are structures expressed by microorganisms [29][30][31][32][33][34]. Generally, the initial sensing of microbial pathogens is mediated by pattern recognition receptors (PRRs) for PAMPs.…”

Interleukin-1 α Alters the Expression of Matrix Metalloproteinases and Collagen Degradation by Pulp Fibroblasts

“…Bacteria are known to be a major contributor to pulpal complications. Bacteria lipopolysaccharides associated with pulpal diseases have been reported to stimulate the production of several cytokines including IL-1␤ (6), IL-6 (7), IL-8 (8), and IL-10 receptor (9), as well as neurotransmitter peptide substance P (10) from human pulp fibroblasts. In contrast, some bacteria associated with endodontic treatment failure such as Enterococcus faecalis inhibited IL-2 and IL-4 production by activated T lymphocytes (11).…”