Interleukins and inflammatory markers are useful in predicting the severity of acute pancreatitis

Abstract

Acute pancreatitis (AP) is a disease with significant morbidity and mortality. The aim of this study was to evaluate the prognostic role of inflammatory markers, particularly interleukins (ILs), in the course of AP and to determine the frequency of etiologic factors of AP. We included patients with AP who were treated at our institution from May 1, 2012 to January 31, 2015. Different laboratory parameters, including ILs, and the severity scoring systems Ranson’s criteria and Bedside Index of Severity in Acute Pancreatitis (BISAP) were analyzed. AP was classified into mild and severe, and independent parameters were compared between these groups. The predictive performance of each parameter was evaluated using receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC). A binomial logistic regression was performed to evaluate Ranson’s criteria and IL6, IL8, and IL10 (at admission and after 48 hours) in the course of AP. Overall, 96 patients were treated, 59 (61.5%) males and 37 (38.5%) females, average age 62.5 ± 16.8 years (range 22–91 years). The best predictor for the severity of AP was IL6, measured 48 hours after admission (AUC = 0.84). Other useful predictors of the severity of AP were lactate dehydrogenase (p < 0.001), serum glucose (p < 0.006), and difference in the platelet count (p < 0.001) between admission and after 48 hours (p < 0.001), hemoglobin (p < 0.027) and erythrocytes (p < 0.029). The major causes of AP were gallstones and alcohol consumption. According to our results, IL6 and Ranson score are important predictors of the severity of AP.

Development an Inflammation-Related Factor-Based Model for Predicting Organ Failure in Acute Pancreatitis: A Retrospective Cohort Study

“…For example, IL6 was the key accelerator in the final differentiation of B-cells into Ig-secreting cells, and IL8 had the function on neutrophil activation [ 17 ]. IL6 and IL8 could take part in a wide variety of inflammation-associated disease by inducing the inflammatory response, such as rheumatoid arthritis [ 18 ], ulcerative colitis [ 19 ], and acute pancreatitis [ 20 ]. In acute pancreatitis, the levels of these cytokines in peripheral blood were abnormally increased and significantly associated with the disease development.…”

TSPAN1 silencing protects against cerulein‐induced pancreatic acinar cell injury via targeting AGR2

“…The severity of AP is associated with increased serum levels of inflammatory cytokines markers including TNF‐α, IL‐1β, IL‐6, IL‐8, and IL‐10 (Chen et al, 2021). Furthermore, IL‐6 is identified as a significant inflammatory cytokine marker in the development of AP (Ćeranić et al, 2020). Findings in the present study indicated that TSPAN1 silencing suppressed the cerulein‐induced hypersecretion of inflammatory cytokines such as TNF‐α and IL‐6.…”

Association of Genetic Variants in IL6 Gene (rs1800795) with the Concentration of Inflammatory Markers (IL-6, hs-CRP) and Superoxide Dismutase in the Blood of Patients with Acute Pancreatitis—Preliminary Findings

“…IL-6, through gp130 protein, takes part in the activation of the Janus kinase/signal transducers and activators (JAK/STAT) signaling pathway [ 9 ]. The concentration of this cytokine increases earlier, and it is a more sensitive marker of severity of inflammation than C-reactive protein (CRP) [ 10 , 11 ]. The release of IL-6 from the inflamed pancreas tissue is associated with the dysfunction of this organ [ 8 , 9 ].…”