Intermediate TCR Cells Can Induce Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation

Weerasinghe, Anura; Kawamura, Toshihiko; Moroda, Tetsuya; Seki, Shuji; Watanabe, Hirotaka; Abo, Toru

doi:10.1006/cimm.1998.1263

Cited by 11 publications

(6 citation statements)

References 40 publications

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“…In recent studies [2,3], we have reported that the mainstream of T‐cell differentiation in the thymus and the extrathymic pathway of T‐cell differentiation in the liver are reciprocally regulated, especially by steroid hormones. In addition to ageing [16–18], an activation of the extrathymic pathway is induced by stress [1–5], malignancy [22,23], autoimmune diseases [24–26], pregnancy [27,28], and chronic GVH disease [29,30]. When ageing and stress were both present, a reciprocal response was prominently seen in the present study (see Fig.…”

Section: Discussionmentioning

confidence: 52%

Age-related bias in function of natural killer T cells and granulocytes after stress: reciprocal association of steroid hormones and sympathetic nerves

Sagiyama

Tsuchida

Kawamura

et al. 2003

Clinical and Experimental Immunology

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SUMMARYStress-associated immune responses were compared between young (8 weeks of age) and old (56 weeks) mice. Since stress suppresses the conventional immune system (i.e. T and B cells) but inversely activates the primordial immune system (i.e. extrathymic T cells, NKT cells, and granulocytes), these parameters were analysed after restraint stress for 24 h. The thymus became atrophic as a function of age, and an age-related increase in the number of lymphocytes was seen in the liver. Although the number of lymphocytes in both the thymus and liver decreased as the result of stress, the magnitude was much more prominent in the thymus. To determine stress-resistant lymphocyte subsets, two-colour immunofluorescence tests were conducted in the liver and spleen. NKT cells were found to be such cells in the liver of young mice. On the other hand, an infiltration of granulocytes due to stress was more prominent in the liver of old mice than in young mice. Liver injury as a result of stress was prominent in young mice. This age-related bias in the function of NKT cells and granulocytes seemed to be associated with a difference in the responses of catecholamines (high in old mice) and corticosterone (high in young mice) after stress. Indeed, an injection of adrenaline mainly induced the infiltration of granulocytes while that of cortisol activated NKT cells. The present results suggest the existence of agerelated bias in the function of NKT cells and granulocytes after stress and that such bias might be produced by different responses of sympathetic nerves and steroid hormones between young and old mice.

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Section: Discussionmentioning

confidence: 52%

Age-related bias in function of natural killer T cells and granulocytes after stress: reciprocal association of steroid hormones and sympathetic nerves

Sagiyama

Tsuchida

Kawamura

et al. 2003

Clinical and Experimental Immunology

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“…Usually, the number and proportion of NKT cells both in the liver and thymus increase when the mainstream of T cell differentiation in the thymus declines. This inverted correlation is eventually seen in aging [22][23][24] and under conditions of pregnancy [25,26], malignancy [27], and chronic GVH diseases [28,29]. A similar correlation is also seen in another subset of primordial T cells, NK1.1 -TCR int cells.…”

Section: Introductionmentioning

confidence: 84%

Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide

et al. 2000

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“…At the same time, severe thymic involution always accompanied the above‐mentioned phenomenon. We previously reported that the extrathymic pathway and intrathymic pathway (the mainstream) of T cell differentiation are reciprocally regulated with aging 29, 30 and under conditions of stress 31, 32, malignancy 33, pregnancy 34, 35, chronic GVH disease 36, etc. In light of these findings, the present results suggest that the activation of NKT cells and CD5 + B cells may occur in parallel with the suppression of thymus‐derived, conventional T cells.…”

Section: Discussionmentioning

confidence: 99%

Tissue-specific expansion of NKT and CD5+B cells at the onset of autoimmune disease in (NZB×NZW)F1 mice

et al. 2002

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Natural killer T (NKT) cells and CD5+B cells were searched for in various immune organs of autoimmune prone (NZB×NZW)F1 (NZB/W F1) mice. The number of lymphocytes increased in the liver, spleen, and peritoneal cavity after the onset of disease (at the age of 30 weeks) while the number of thymocytes decreased at that time. Prominent changes of lymphocyte subsets were seen in the liver and peritoneal cavity, namely, expansion of IL‐2Rβ+TCRα βint cells in the liver and of CD5+B220+ cells in the peritoneal cavity. The majority of TCRα βint cells in the liver were NK1.1+, and CD5+B cells in the peritoneal cavity were CD1d+. Proteinuria became prominent in NZB/W F1 mice with the progression of disease. In parallel with this progression, the proportion of NKT cells decreased slightly in the liver, but their absolute number remained at a high level in this organ. These NKT cells were CD4+ and used an invariant chain of Vα14Jα281 for TCRα. Reflecting the elevation of CD5+B cells, autoantibodies against hepatocyte cytoplasmand denatured DNA were detected in sera. Although NKT cells are known to be immunoregulatory cells in some autoimmune mice, the present results raise the possibility that NKT cells as well as CD5+B cells might be associated with the onset of autoimmune diseases in NZB/W F1 mice. Indeed, NKT cells in F1 mice had a high potential to induce autoimmune‐like inflammationwhen α–galactosylceramide was administered or when active NKT cells were transferred into young F1 mice.

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Intermediate TCR Cells Can Induce Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation

Cited by 11 publications

References 40 publications

Age-related bias in function of natural killer T cells and granulocytes after stress: reciprocal association of steroid hormones and sympathetic nerves

Age-related bias in function of natural killer T cells and granulocytes after stress: reciprocal association of steroid hormones and sympathetic nerves

Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide

Tissue-specific expansion of NKT and CD5+B cells at the onset of autoimmune disease in (NZB×NZW)F1 mice

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