Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: Crosstalk among calorie restriction, autophagy and immune response

Hannan, Md. Abdul; Rahman, Ataur; Rahman, Saidur; Sohag, Abdullah Al Mamun; Dash, Raju; Hossain, Khandkar Shaharina; Farjana, Mithila; Uddin, Jamal

doi:10.1016/j.imlet.2020.07.001

Cited by 60 publications

(48 citation statements)

References 81 publications

(102 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IF can activate immune responses ( Cheng et al, 2014 ) and induce autophagy, which is the elimination of dysfunctional organelles and proteins, as well as invading pathogens ( Bagherniya et al, 2018 ), and through distinct mechanisms, stimulates the immune system and primes host defense; therefore, along with the other effects mentioned above, IF could be a potential preventative approach to COVID-19 ( Hannan et al, 2020 ). However, this is not recommended for everyone, as spontaneous fasting could have adverse effects even among healthy individuals.…”

Section: Therapeutic Opportunitiesmentioning

confidence: 99%

Altered immunoemotional regulatory system in COVID-19: From the origins to opportunities

Pourriyahi

Saghazadeh

Rezaei

2021

Journal of Neuroimmunology

View full text Add to dashboard Cite

The emergence of the novel coronavirus (SARS-CoV-2) and the worldwide spread of the coronavirus disease (COVID-19) have led to social regulations that caused substantial changes in daily life. The subsequent loneliness and concerns of the pandemic during social distancing, quarantine, and lockdown are psychosocial stressors that negatively affect the immune system. These effects occur through mechanisms controlled by the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenocortical (HPA) axis that alter immune regulation, namely the conserved transcriptional response to adversity (CTRA), which promotes inflammation and diminishes antiviral responses, leading to inadequate protection against viral disease. Unhealthy eating habits, physical inactivity, sleep disturbances, and mental health consequences of COVID-19 add to the pathological effects of loneliness, making immunity against this lethal virus an even tougher fight. Therefore, social isolation, with its unintended consequences, has inherently paradoxical effects on immunity in relation to viral disease. Though this paradox can present a challenge, its acknowledgment can serve as an opportunity to address the associated issues and find ways to mitigate the adverse effects. In this review, we aim to explore, in detail, the pathological effects of the new social norms on immunity and present suggested methods to improve our physical, psychological, and healthcare abilities to fight a viral infection in the context of the COVID-19 pandemic.

show abstract

Section: Therapeutic Opportunitiesmentioning

confidence: 99%

Altered immunoemotional regulatory system in COVID-19: From the origins to opportunities

Pourriyahi

Saghazadeh

Rezaei

2021

Journal of Neuroimmunology

View full text Add to dashboard Cite

show abstract

“…SARS-CoV-2 infection suppresses autophagy (Gassen et al, 2020;Hannan, Rahman, et al, 2020). While autophagy machinery is essential for their replication, some viruses evolved strategies to evade autophagy flux (Gassen et al, 2019).…”

Section: Autophagymentioning

confidence: 99%

Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID‐19 prevention and cure

Islam

Hossain

Sarker

et al. 2020

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

Nigella sativa seed and its active compounds have been historically recognized as an effective herbal panacea that can establish a balanced inflammatory response by suppressing chronic inflammation and promoting healthy immune response. The essential oil and other preparations of N. sativa seed have substantial therapeutic outcomes against immune disturbance, autophagy dysfunction, oxidative stress, ischemia, inflammation, in several COVID‐19 comorbidities such as diabetes, cardiovascular disorders, Kawasaki‐like diseases, and many bacterial and viral infections. Compelling evidence in the therapeutic efficiency of N. sativa along with the recent computational findings is strongly suggestive of combating emerged COVID‐19 pandemic. Also, being an available candidate in nutraceuticals, N. sativa seed oil could be immensely potential and feasible to prevent and cure COVID‐19. This review was aimed at revisiting the pharmacological benefits of N. sativa seed and its active metabolites that may constitute a potential basis for developing a novel preventive and therapeutic strategy against COVID‐19. Bioactive compounds of N. sativa seed, especially thymiquinone, α‐hederin, and nigellidine, could be alternative and promising herbal drugs to combat COVID‐19. Preclinical and clinical trials are required to delineate detailed mechanism of N. sativa 's active components and to investigate their efficacy and potency under specific pathophysiological conditions of COVID‐19.

show abstract

“…As a proof of concept, recent study demonstrated the utility of three different autophagy-inducing drugs, spermidine, MK02206, and niclosamide, in restricting SARS-CoV-2 propagation [ 138 ]. Autophagy induction and related upregulation of overall immunity helps combat exacerbations and is suggested as an immunity boosting strategy as a preventive measure against COVID-19 [ 139 ]. In addition to boosting immunity, dampening viral load, and allowing SARS-COV2 clearance, autophagy induction may provide strategic advantage in the treatment of COVID-19 and prevention of negative outcomes, which makes it a subject of ongoing studies.…”

Section: Autophagy Dysfunction In Respiratory Diseasesmentioning

confidence: 99%

Autophagy Augmentation to Alleviate Immune Response Dysfunction, and Resolve Respiratory and COVID-19 Exacerbations

Pehote

Vij

2020

Cells

View full text Add to dashboard Cite

The preservation of cellular homeostasis requires the synthesis of new proteins (proteostasis) and organelles, and the effective removal of misfolded or impaired proteins and cellular debris. This cellular homeostasis involves two key proteostasis mechanisms, the ubiquitin proteasome system and the autophagy–lysosome pathway. These catabolic pathways have been known to be involved in respiratory exacerbations and the pathogenesis of various lung diseases, such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), idiopathic pulmonary fibrosis (IPF), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and coronavirus disease-2019 (COVID-19). Briefly, proteostasis and autophagy processes are known to decline over time with age, cigarette or biomass smoke exposure, and/or influenced by underlying genetic factors, resulting in the accumulation of misfolded proteins and cellular debris, elevating apoptosis and cellular senescence, and initiating the pathogenesis of acute or chronic lung disease. Moreover, autophagic dysfunction results in an impaired microbial clearance, post-bacterial and/or viral infection(s) which contribute to the initiation of acute and recurrent respiratory exacerbations as well as the progression of chronic obstructive and restrictive lung diseases. In addition, the autophagic dysfunction-mediated cystic fibrosis transmembrane conductance regulator (CFTR) immune response impairment further exacerbates the lung disease. Recent studies demonstrate the therapeutic potential of novel autophagy augmentation strategies, in alleviating the pathogenesis of chronic obstructive or restrictive lung diseases and exacerbations such as those commonly seen in COPD, CF, ALI/ARDS and COVID-19.

show abstract

Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: Crosstalk among calorie restriction, autophagy and immune response

Abstract: Graphical abstract

Cited by 60 publications

References 81 publications

Altered immunoemotional regulatory system in COVID-19: From the origins to opportunities

Altered immunoemotional regulatory system in COVID-19: From the origins to opportunities

Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID‐19 prevention and cure

Autophagy Augmentation to Alleviate Immune Response Dysfunction, and Resolve Respiratory and COVID-19 Exacerbations

Contact Info

Product

Resources

About