Intermittent Fasting After Spinal Cord Injury Does Not Improve the Recovery of Baroreflex Regulation in the Rat

Abstract

Modest recovery of somatic function after incomplete spinal cord injury (SCI) has been widely demonstrated. Recently we have shown that spontaneous recovery of baroreflex regulation of sympathetic activity also occurs in rats. Dietary restriction in the form of every other day fasting (EODF) has been shown to have beneficial effects on the recovery of motor function after SCI in rats. The goal of this study was to determine if EODF augments the improvement of baroreflex regulation of sympathetic activity after chronic left thoracic (T 8 ) surgical spinal hemisection. To determine this, we performed baroreflex tests on ad-lib fed or EODF rats 1 week or 7 weeks after left T 8 spinal hemisection. One week after T 8 left hemisection baroreflex testing revealed that gain of baroreflex responsiveness, as well as the ability to increase renal sympathetic nerve activity (RSNA) at low arterial pressure, was significantly impaired in the ad-lib fed but not the EODF rats compared with sham lesioned control rats. However, baroreflex tests performed 7 weeks after T 8 left hemisection revealed the inability of both ad-lib and EODF rats to decrease RSNA at elevated arterial pressures. While there is evidence to suggest that EODF has beneficial effects on the recovery of motor function in rats, EODF did not significantly improve the recovery of baroreflex regulation of sympathetic activity.

Systematic Review ‐ Neuroprotection of ketosis in acute injury of the mammalian central nervous system: A meta‐analysis

“…The 49 articles finally selected were published over a four‐decade span (1979–2020) (Anson et al., 2003; Appelberg et al., 2009; Arumugam et al., 2010; Biros et Nordness, 1996; Bruce‐Keller et al., 1999; Davis et al., 2008; Duan et al., 2001; Eiger et al., 1980; Go et al., 1988; Gueldry et al., 1990; Hu, et al., 2009; Hu, Wang, Qiao, et al., 2009; Jeong et al., 2011; Kirsch et D’Alecy, 1979, 1983; Kirsch et al., 1980; Lee et al., 2018; Lu et al., 2018; Lundy et al., ,1984, 1985; Marie et a, 1987; Marie et al., 1990; Mayr et al., 2020; Plunet et al., ,2008, 2010; Prins et al., 2005; Prins et al., 2009; Puchowicz et al., 2008; Rahman et al., 2014; Rising et D’Alecy, 1989; Ritter et al., 1996; Robertson et al., 1992; Rubovitch et al., 2019; Salberg et al., 2019; Schwartzkroin et al., 2010; Sharma et Kaur, 2005; Sims et Heward, 1994; Streijger et al., ,2011, 2013; Suzuki et al., ,2001, 2002; Tai et al., 2008; Tai et Truong, 2007; Tan et al., 2020; Yager et al., 1992; Yamada et al., 2005; Yin et al., 2015; Yu et Mattson, 1999; Zahner et Beaumont, 2020). Details regarding publication, model, type of experiment, and intervention are available in Table 1.…”