Intermittent hypoxia changes the interaction of the kinin–VEGF system and impairs myocardial angiogenesis in the hypertrophic heart

Visniauskas, Bruna; Perry, Juliana C.; Gomes, Guiomar Nascimento; Nogueira‐Pedro, Amanda; Paredes‐Gamero, Edgar Julian; Tufik, Sérgio; Chagas, Jair Ribeiro

doi:10.14814/phy2.14863

Cited by 6 publications

(6 citation statements)

References 66 publications

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“…Obstructive Sleep Apnea Syndrome (OSAS) is a sleep-related breathing disorder characterized by transient interruption of ventilation during sleep caused by complete or partial occlusion of the upper airway (McNicholas et al, 2007). Consequent oxygen desaturation, increased inspiratory effort, sleep fragmentation, and arousal from sleep (Lévy et al, 2015;Jennum et al, 2021) lead to excessive daytime sleepiness, cardiovascular, and metabolic diseases (Pépin et al, 2019;Visniauskas et al, 2021), cognitive and memory impairments (Alomri et al, 2021;Huang et al, 2021;Legault et al, 2021), and mood disorders (Garbarino et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Improving CPAP Adherence in Adults With Obstructive Sleep Apnea Syndrome: A Scoping Review of Motivational Interventions

et al. 2021

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Objective: This scoping review aims to provide an accessible summary of available evidence on the efficacy of motivational interventions to increase adherence to Continuous Positive Airway Pressure (CPAP) among patients with Obstructive Sleep Apnea Syndrome (OSAS) and of their specific aspects and strategies by assessing adherence measures.Methods: A literature search was performed in PubMed, Scopus, Medline, PsycINFO, and Web of Science databases using the concepts of “obstructive sleep apnea syndrome,” “continuous positive airway pressure,” “motivational intervention,” and “adherence.” Rigorous inclusion criteria and screening by at least two reviewers were applied. Data were extracted to address the review aims and were presented as a narrative synthesis.Results: Search for databases produced 11 randomized controlled trials, all including naïve CPAP users. Findings showed that motivational interventions were more effective than usual care and educational programs in increasing adherence to CPAP, despite results were not always maintained over time across studies.Discussion: To our knowledge, this is the first scoping review of the literature aimed to explore the characteristics and impact of motivational interventions to promote adherence to CPAP in patients with OSAS. More research providing a detailed description of motivational strategies, and testing of their association with positive treatment outcomes via both direct and indirect measures are needed to increase awareness on active mechanisms of change.

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Section: Introductionmentioning

confidence: 99%

Improving CPAP Adherence in Adults With Obstructive Sleep Apnea Syndrome: A Scoping Review of Motivational Interventions

et al. 2021

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“…In contrast, the most significant genes associated with adverse outcomes in South Asia were HSPD1, FKBP4 , and SE RPINH1 . These genes are mainly associated with oxidative stress and intermittent hypoxia resembling reperfusion injury, production of reactive oxygen species, and inflammation . HSPD1 , a heat shock factor, is upregulated within 8 hours after short-term chronic hypoxia .…”

Section: Discussionmentioning

confidence: 99%

“…These genes are mainly associated with oxidative stress and intermittent hypoxia resembling reperfusion injury, production of reactive oxygen species, and inflammation. 23 , 24 HSPD1 , a heat shock factor, is upregulated within 8 hours after short-term chronic hypoxia. 25 HSPD1 is also increased in patients with temporal lobe epilepsy in response to seizures.…”

Section: Discussionmentioning

confidence: 99%

Whole-Blood Gene Expression Profile After Hypoxic-Ischemic Encephalopathy

Montaldo,

Burgod,

Herberg

et al. 2024

JAMA Netw Open

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ImportanceInduced hypothermia, the standard treatment for hypoxic-ischemic encephalopathy (HIE) in high-income countries (HICs), is less effective in the low-income populations in South Asia, who have the highest disease burden.ObjectiveTo investigate the differences in blood genome expression profiles of neonates with HIE from an HIC vs neonates with HIE from South Asia.Design, Setting, and ParticipantsThis case-control study analyzed data from (1) a prospective observational study involving neonates with moderate or severe HIE who underwent whole-body hypothermia between January 2017 and June 2019 and age-matched term healthy controls in Italy and (2) a randomized clinical trial involving neonates with moderate or severe HIE in India, Sri Lanka, and Bangladesh recruited between August 2015 and February 2019. Data were analyzed between October 2020 and August 2023.ExposureWhole-blood RNA that underwent next-generation sequencing.Main Outcome and MeasuresThe primary outcomes were whole-blood genome expression profile at birth associated with adverse outcome (death or disability at 18 months) after HIE in the HIC and South Asia cohorts and changes in whole-genome expression profile during the first 72 hours after birth in neonates with HIE and healthy controls from the HIC cohort. Blood samples for RNA extraction were collected before whole-body hypothermia at 4 time points (6, 24, 48, and 72 hours after birth) for the HIC cohort. Only 1 blood sample was drawn within 6 hours after birth for the South Asia cohort.ResultsThe HIC cohort was composed of 35 neonates (21 females [60.0%]) with a median (IQR) birth weight of 3.3 (3.0-3.6) kg and gestational age of 40.0 (39.0-40.6) weeks. The South Asia cohort consisted of 99 neonates (57 males [57.6%]) with a median (IQR) birth weight of 2.9 (2.7-3.3) kg and gestational age of 39.0 (38.0-40.0) weeks. Healthy controls included 14 neonates (9 females [64.3%]) with a median (IQR) birth weight of 3.4 (3.2-3.7) kg and gestational age of 39.2 (38.9-40.4) weeks. A total of 1793 significant genes in the HIC cohort and 99 significant genes in the South Asia cohort were associated with adverse outcome (false discovery rate &lt;0.05). Only 11 of these genes were in common, and all had opposite direction in fold change. The most significant pathways associated with adverse outcome were downregulation of eukaryotic translation initiation factor 2 signaling in the HIC cohort (z score = −4.56; P &lt; .001) and aldosterone signaling in epithelial cells in the South Asia cohort (z score = null; P &lt; .001). The genome expression profile of neonates with HIE (n = 35) at birth, 24 hours, 48 hours, and 72 hours remained significantly different from that of age-matched healthy controls in the HIC cohort (n = 14).Conclusions and RelevanceThis case-control study found that disease mechanisms underlying HIE were primarily associated with acute hypoxia in the HIC cohort and nonacute hypoxia in the South Asia cohort. This finding might explain the lack of hypothermic neuroprotection.

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“…36 A prior study by Visniauskas et al showed that myocardial angiogenesis and capillary density were both decreased from the third to the fifth weeks of CIH exposure, accompanied by delayed increase in both gene and protein expression of VEGF. 37 They further demonstrated that this discrepancy was related to the classic interaction between VEGF and kallikrein-kinin system (KKS) components, and their temporal expressions were not sufficient to stimulate the formation of new blood vessels. This could partially explain our results.…”

Section: Discussionmentioning

confidence: 99%

Berberine ameliorates chronic intermittent hypoxia‐induced cardiac remodelling by preserving mitochondrial function, role of SIRT6 signalling

Zhou,

Zhao,

Huang

et al. 2024

J Cellular Molecular Medi

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Chronic intermittent hypoxia (CIH) is associated with an increased risk of cardiovascular diseases. Previously, we have shown that berberine (BBR) is a potential cardioprotective agent. However, its effect and mechanism on CIH‐induced cardiomyopathy remain uncovered. This study was designed to determine the effects of BBR against CIH‐induced cardiac damage and to explore the molecular mechanisms. Mice were exposed to 5 weeks of CIH with or without the treatment of BBR and adeno‐associated virus 9 (AAV9) carrying SIRT6 or SIRT6‐specific short hairpin RNA. The effect of BBR was evaluated by echocardiography, histological analysis and western blot analysis. CIH caused the inactivation of myocardial SIRT6 and AMPK‐FOXO3a signalling. BBR dose‐dependently ameliorated cardiac injury in CIH‐induced mice, as evidenced by increased cardiac function and decreased fibrosis. Notably, SIRT6 overexpression mimicked these beneficial effects, whereas infection with recombinant AAV9 carrying SIRT6‐specific short hairpin RNA abrogated them. Mechanistically, BBR reduced oxidative stress damage and preserved mitochondrial function via activating SIRT6‐AMPK‐FOXO3a signalling, enhancing mitochondrial biogenesis as well as PINK1‐Parkin‐mediated mitophagy. Taken together, these data demonstrate that SIRT6 activation protects against the pathogenesis of CIH‐induced cardiac dysfunction. BBR attenuates CIH‐induced myocardial injury by improving mitochondrial biogenesis and PINK1‐Parkin‐dependent mitophagy via the SIRT6‐AMPK‐FOXO3a signalling pathway.

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Intermittent hypoxia changes the interaction of the kinin–VEGF system and impairs myocardial angiogenesis in the hypertrophic heart

Cited by 6 publications

References 66 publications

Improving CPAP Adherence in Adults With Obstructive Sleep Apnea Syndrome: A Scoping Review of Motivational Interventions

Improving CPAP Adherence in Adults With Obstructive Sleep Apnea Syndrome: A Scoping Review of Motivational Interventions

Whole-Blood Gene Expression Profile After Hypoxic-Ischemic Encephalopathy

Berberine ameliorates chronic intermittent hypoxia‐induced cardiac remodelling by preserving mitochondrial function, role of SIRT6 signalling

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