Intermittent theta burst stimulation (iTBS) adjustment effects of schizophrenia: Results from an exploratory outcome of a randomized double-blind controlled study

Wang, Lu; Chen, Xingui; Wu, Yang; He, Kai; Xu, Fei; Xiao, Guixian; Hu, Panpan; Qiu, Bensheng; Ji, Gong‐Jun; Wang, Kai

doi:10.1016/j.schres.2019.12.008

Cited by 21 publications

(29 citation statements)

References 7 publications

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“…Dorso-lateral PFCx weaker processing of sensory information from thalamus is in fact associated with hallucination experiences which are common in > 50% of the SCZ patients ( Daskalakis et al., 2020 ). The molecular studies point at parvalbumin positive (PV+) GABAergic interneurons and cortical pyramidal cells networks as both altered in SCZ PFCx and across species in SCZ models ( Chung et al., 2018 ; Petralia et al., 2020 ; Wang et al., 2020 ; Weidenauer et al., 2020 ). Dopaminergic ascending terminals reaching these neurons are also hypofunctional ( Rao et al., 2019 ).…”

Section: Section 2: Dr Alterations In Schizophreniamentioning

confidence: 99%

Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia

Martel¹,

McArthur²

2020

Front. Pharmacol.

177

125

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Dopamine receptors are widely distributed within the brain where they play critical modulator roles on motor functions, motivation and drive, as well as cognition. The identification of five genes coding for different dopamine receptor subtypes, pharmacologically grouped as D1- (D1 and D5) or D2-like (D2S, D2L, D3, and D4) has allowed the demonstration of differential receptor function in specific neurocircuits. Recent observation on dopamine receptor signaling point at dopamine—glutamate-NMDA neurobiology as the most relevant in schizophrenia and for the development of new therapies. Progress in the chemistry of D1- and D2-like receptor ligands (agonists, antagonists, and partial agonists) has provided more selective compounds possibly able to target the dopamine receptors homo and heterodimers and address different schizophrenia symptoms. Moreover, an extensive evaluation of the functional effect of these agents on dopamine receptor coupling and intracellular signaling highlights important differences that could also result in highly differentiated clinical pharmacology. The review summarizes the recent advances in the field, addressing the relevance of emerging new targets in schizophrenia in particular in relation to the dopamine – glutamate NMDA systems interactions.

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Section: Section 2: Dr Alterations In Schizophreniamentioning

confidence: 99%

Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia

Martel¹,

McArthur²

2020

Front. Pharmacol.

177

125

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“…On average, each participant has 41.09 [95%, (40,42)] components remaining. The mean proportion of rejected epochs was 9.75% [95%, (6,13)] in pre_iTBS group, 13.98% [95%, (7,21)] in pre_sham group, 13.98% [95%, (7,21)] in post_iTBS group and 15.81% [95%, (8,23)] in post_iTBS group. Rejection rates did not differ significantly among groups (F = 0.909, p = 0.441).…”

Section: Electrophysiological Recordingsmentioning

confidence: 99%

“…iTBS consists of clusters of burst stimulation to excite the cerebral cortex, which affects brain metabolism and the electrical activity of nerves, with the advantages of no pain or damage, and shorter treatment time (19,20). In addition, previous studies have proved the effectiveness of iTBS in interfering with the symptoms of schizophrenia (21). Thus, iTBS combined with magnetic resonance imaging (MRI)-guided navigation would have greater efficacy and may be a preferred strategy for the treatment of decision-making disorders in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Intermittent Theta Burst Stimulation (iTBS) as an Optimal Treatment for Schizophrenia Risk Decision: an ERSP Study

Wang²,

Yu³

et al. 2021

Front. Psychiatry

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Objective: People with schizophrenia have serious impairments in social function, especially in decision-making ability. Transcranial magnetic stimulation modified intermittent theta burst transcranial magnetic stimulation (iTBS) has been shown to regulate the functional connection of brain networks. Our study explored the therapeutic effect of iTBS on decision-making disorders in schizophrenia.Methods: Participants were pseudorandomized and assigned to iTBS (n = 16) or sham (n = 16) group. iTBS group was administered 1,800 pulses on the target of the left dorsol lateral prefrontal cortex (L-DLPFC) per day for 14 consecutive days. We compared Iowa gambling task performance and associated event-related spectral perturbation results (ERSP) among two groups.Results: The results show that participants' performance in the high-lose in the iTBS group had stronger stimulation of theta spectral power than those in the sham group. Specifically, we found that under high-risk conditions, compared with the control group, the iTBS group showed significant activation of the theta spectrum power in the FPZ, FZ, FCZ, and CZ regions after treatment.Conclusions: Our results provide evidence that long-term iTBS stimulation effectively improves the decision-making ability of schizophrenia. After receiving negative feedback, patients can turn to safety options. These findings support that iTBS may be a potential treatment for clinical decision-making disorders.

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“…Specifically, we aimed to identify the more effective between the two TMS protocols, and based on previous findings, the L‐DLPFC was chosen as the stimulation target (Wang et al., 2020). Therefore, we hypothesized that excitation of the DLPFC could result in more safe choices over time.…”

Section: Introductionmentioning

confidence: 99%

“…To date, the effect of feedback on decision-making has not been investigated or compared with traditional high-frequency rTMS in the same context. Specifically, we aimed to identify the more effective between the two TMS protocols, and based on previous findings, the L-DLPFC was chosen as the stimulation target (Wang et al, 2020). Therefore, we hypothesized that excitation of the DLPFC could result in more safe choices over time.…”

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confidence: 99%

Better modulation for risk decision‐making after optimized magnetic stimulation

Wang

et al. 2021

J of Neuroscience Research

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Decision-making, as a kind of high-level cognitive process that involves selecting response options that will ultimately maximize gains while minimizing losses, is of great significance to human survival and adaptation (Hsu et al., 2005). Adaptive decision-making is important for utilizing only relevant and valid feedback and ignoring irrelevant feedback. Individuals can capitalize on feedback to provide learning

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Intermittent theta burst stimulation (iTBS) adjustment effects of schizophrenia: Results from an exploratory outcome of a randomized double-blind controlled study

Cited by 21 publications

References 7 publications

Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia

Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia

Intermittent Theta Burst Stimulation (iTBS) as an Optimal Treatment for Schizophrenia Risk Decision: an ERSP Study

Better modulation for risk decision‐making after optimized magnetic stimulation

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