Intermolecular interactions between imidazolium- and cholinium-based ionic liquids and lysozyme: Regularities and peculiarities

Khachatrian, Artashes A.; Mukhametzyanov, Timur A.; Yakhvarov, Dmitry G.; Sinyáshin, O. G.; Garifullin, B. F.; Rakipov, Ilnaz T.; Mironova, Diana A.; Burilov, Vladimir; Solomonov, Boris N.

doi:10.1016/j.molliq.2021.118426

Cited by 11 publications

(4 citation statements)

References 51 publications

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“…Furthermore, the thermal stability of HEWL in aqueous solutions containing ionic liquids was determined using the circular dichroism spectroscopy (CD) method. In most cases, the most studied ILs have little effect on the fluorescence of lysozyme, according to fluorescence data, and no effect on its native secondary and tertiary structure at room temperature, according to CD data [ 186 ]. Kumari et al studied the inhibiting effect of ammonium and choline-based ILs, including tetrabutylammonium methanesulfonate (TBAMS), tetrabutylammonium chloride (TBACl), and choline chloride (CholCl), on amyloid aggregation of superoxide dismutase 1 (SOD1).…”

Section: Ionic Liquids In Biomedical Applicationsmentioning

confidence: 99%

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review

Zhuo,

Cheng,

Zhao

et al. 2024

Pharmaceutics

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The unique properties of ionic liquids (ILs), such as structural tunability, good solubility, chemical/thermal stability, favorable biocompatibility, and simplicity of preparation, have led to a wide range of applications in the pharmaceutical and biomedical fields. ILs can not only speed up the chemical reaction process, improve the yield, and reduce environmental pollution but also improve many problems in the field of medicine, such as the poor drug solubility, product crystal instability, poor biological activity, and low drug delivery efficiency. This paper presents a systematic and concise analysis of the recent advancements and further applications of ILs in the pharmaceutical field from the aspects of drug synthesis, drug analysis, drug solubilization, and drug crystal engineering. Additionally, it explores the biomedical field, covering aspects such as drug carriers, stabilization of proteins, antimicrobials, and bioactive ionic liquids.

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Section: Ionic Liquids In Biomedical Applicationsmentioning

confidence: 99%

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review

Zhuo,

Cheng,

Zhao

et al. 2024

Pharmaceutics

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“…The interactions between ILs and proteins depend on H-bonds, van der Waals force, hydrophobic interactions, etc. 155,165–168 For instance, anions of choline-based ILs choline iodide, choline bitartrate, and choline dihydrogen citrate ([Ch][I], [Ch][Bit] and [Ch][Dhc]) could spontaneously combine with the residues of bovine serum albumin (BSA) by H-bonds and van der Waals force, changing the natural structure of BSA significantly. 165 Choline geranic acid ILs (CAGE) could inhibit human neutrophil elastase at low concentrations by disrupting the hydrophobic effect.…”

Section: Therapeutic Components and Mechanismmentioning

confidence: 99%

“…The interactions between ILs and proteins depend on H-bonds, van der Waals force, hydrophobic interactions, etc. 155,[165][166][167][168] For instance, anions of choline-based ILs choline iodide, choline bitartrate, and choline dihydrogen citrate…”

Section: Interactions Between Ils and Cell Organellesmentioning

confidence: 99%

Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities

Hu,

Xing,

Yue

et al. 2023

Chem. Soc. Rev.

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“…Since ILs do not emit toxic organic compounds into the environment and are biocompatible, they are considered as green and sustainable solvents. Particularly, Chn ILs because of their lower toxicity and high biodegradability are becoming the choice for replacing organic solvents and also other families of ILs. − A schematic representation of the effect of organic solvents and ILs on the native state of proteins is provided in Scheme .…”

Section: Advantages Of Cholinium-based Ionic Liquids Over Organic Sol...mentioning

confidence: 99%

Contemporary Advancement of Cholinium-Based Ionic Liquids for Protein Stability and Long-Term Storage: Past, Present, and Future Outlook

Sindhu

Kumar

Venkatesu

2022

ACS Sustainable Chem. Eng.

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In the past two decades, ionic liquids (ILs) have been acknowledged as potentially attractive “green” and “designer” solvents since their broader chemical space and the tunable nature of the diverse ions can finely modulate their physiochemical properties while enabling task-specific optimization. They have found numerous applications in fields ranging from enzymatic reactions to protein preservation, which focused on the development of various types of ILs and their application for providing protein stability in vitro. Among various families of ILs, some of them have serious limitations similar to organic solvents; they cause environmental toxicity as they are non-biodegradable. In other words, some of the ILs impart stress to biomolecules and ultimately denature the protein. In this regard, the need for biocompatible ILs has come to the light and cholinium-based ILs (Chn ILs) have proved themselves as the most promising ILs to support the structure of biomolecules. The family of Chn ILs has only taken growth in recent years. Despite the numerous studies, more exhaustive research in the field of Chn ILs and biomolecules still needs acceleration. Herein, we review the strategies and current progress on Chn ILs for protein and enzyme-based applications keeping in mind all crucial past and present research outcomes. Furthermore, we elucidate an overview of the various ways to enhance enzymatic activity, structural stability, and long-term storage of proteins in the presence of Chn ILs. We believe these insights will be fruitful for designing various processes based on ILs in the diverse field of biotechnology and ILs will serve as novel solvents for protein stability and enzymatic reactions, maintaining their utility in industrial and biomedical based applications. The huge varieties of biobased Chn ILs hold the promise of recent advances and developments for the correct selection of long-term storage of enzymes.

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Intermolecular interactions between imidazolium- and cholinium-based ionic liquids and lysozyme: Regularities and peculiarities

Cited by 11 publications

References 51 publications

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review

Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities

Contemporary Advancement of Cholinium-Based Ionic Liquids for Protein Stability and Long-Term Storage: Past, Present, and Future Outlook

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