International Diabetes Federation Position Statement on the 1-hour post-load plasma glucose for the diagnosis of intermediate hyperglycaemia and type 2 diabetes

Bergman, Michael; Manco, Melania; Satman, Ilhan; Chan, Juliana; Schmidt, Maria Inês; Sesti, Giorgio; Vanessa Fiorentino, Teresa; Abdul-Ghani, Muhammad; Jagannathan, Ram; Kumar Thyparambil Aravindakshan, Pramod; Gabriel, Rafael; Mohan, Viswanathan; Buysschaert, Martin; Bennakhi, Abdullah; Pascal Kengne, Andre; Dorcely, Brenda; Nilsson, Peter M.; Tuomi, Tiinamaija; Battelino, Tadej; Hussain, Akhtar; Ceriello, Antonio; Tuomilehto, Jaakko

doi:10.1016/j.diabres.2024.111589

Cited by 31 publications

(1 citation statement)

References 197 publications

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“…Even more recently, the International Diabetes Federation published a position statement document declaring that a plasma glucose value ≥155 mg/dL one hour after the glucose load should be considered highly predictive for detecting progression to type 2 diabetes, micro and macrovascular alterations, fatty liver associated with metabolic dysfunction, and increased mortality in subjects with risk factors. All this is to screen subjects who will evolve towards prediabetes and overt type 2 diabetes before irreversible organ damage occurs and to intervene with appropriate treatments for preventive purposes [22]. It is not the intent of this manuscript to describe in detail the intimate mechanisms underlying the development of damage in different districts of the human organism by Hypein.…”

Section: Insulin Resistance/hyperinsulinemiamentioning

confidence: 99%

Insulin Resistance/Hyperinsulinemia as an Independent Risk Factor That Has Been Overlooked for Too Long

Fazio,

Affuso,

Cesaro

et al. 2024

Biomedicines

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Unfortunately, cardiovascular diseases and cancers are still the leading causes of death in developed and developing countries despite the considerable progress made in the prevention and treatment of diseases. Maybe we missed something? Insulin resistance (IR) with associated hyperinsulinemia (Hypein) is a silent pandemic whose prevalence is continually growing in developed and developing countries, now exceeding 51% of the general population. IR/Hypein, despite the vast scientific literature supporting its adverse action on the development of type 2 diabetes, cardiovascular alterations, tumors, neurological disorders, and cellular senescence, is not yet considered an independent risk factor and, therefore, is not screened in the general population and adequately treated. There are now numerous substances, drugs, and natural substances that, in association with the correction of a wrong lifestyle, can help to reduce IR/Hypein. We are convinced that the time has come to implement a prevention plan against this critical risk factor. Therefore, this manuscript aims to highlight IR/Hypein as an independent risk factor for type 2 diabetes, cardiovascular diseases, cancers, cellular senescence, and neuropsychiatric disorders, supporting our conviction with the available scientific literature on the topic.

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Section: Insulin Resistance/hyperinsulinemiamentioning

confidence: 99%