International Prostate Symptom Score is a predictive factor of lower urinary tract symptoms after radical prostatectomy

Abstract

Objective: To evaluate the impact of radical prostatectomy on lower urinary tract symptoms by using the International Prostate Symptom Score and International Prostate Symptom Score quality of life. Methods: The present prospective study comprised 804 patients having localized prostate cancer who underwent radical prostatectomy. International Prostate Symptom Score and International Prostate Symptom Score quality of life were recorded preoperatively, and at 1, 3, 6, 12 and 24 months. Two study groups were considered: group 1 included patients with International Prostate Symptom Score 7 (mild) and group 2 included patients with International Prostate Symptom Score 8 (moderate to severe). Student's t-test and logistic regression were carried out to detect a predictive factor of International Prostate Symptom Score 7 at 24 months. Results: The mean International Prostate Symptom Score was 5.58 ± 6.6, 11.12 ± 7.1 and 7.62 ± 6 at baseline, 1 month and 3 months, respectively (P <0.0001). The mean quality of life score showed the same evolution with a significant difference at 1 and 3 months. The mean International Prostate Symptom Score was initially 1.57 ± 1.9 in group 1 and 13.51 ± 5.5 in group 2 (P <0.0001), evolving to 3.41 ± 3.1 and 7.69 ± 5.8 at 24 months (P <0.0001), respectively. The mean quality of life score was significantly different between the groups initially, and at 6 and 12 months with P <0.0001, P = 0.005 and P = 0.02, respectively. The multivariate logistic regression showed that age, prostate volume and preoperative International Prostate Symptom Score were independent predictive factors of International Prostate Symptom Score 7 at 24 months (P <0.0001). In group 2, 47 patients (17%) had an International Prostate Symptom Score 8 at 24 months, 15 of them (32%) having a QoL score 3.Conclusions: The present study shows the beneficial impact of radical prostatectomy on lower urinary tract symptoms. However, a proportion of patients with a baseline International Prostate Symptom Score 8 maintain the same score at 24 months, with worsening in quality of life score in one-third of them.

Improved lower urinary tract symptoms after robot‐assisted radical prostatectomy: implications for survivorship, treatment selection and patient counselling

“…Analysis of the long-term treatment sequelae, such as LUTS and QoL, using the IPSS and its corresponding QoL scores, has been widely used in the BPH literature to allow comparison among studies, and can be repeated to assess progression, recurrence and severity of symptoms over time [41,42]. When applied to LUTS after PCa treatment, the use of the IPSS allows surgeons to better counsel patients regarding post-treatment urinary function.…”

Comparison of functional outcomes between laparoscopic radical prostatectomy and robot-assisted laparoscopic radical prostatectomy: a propensity score-matched comparison study

“…International Prostate Symptom Score (IPSS) and International Index of Erectile Function‐5 (IIEF‐5) were predictive parameters of urinary and erectile function . Therefore, all patients completed self‐administered questionnaires concerning their urinary and erectile function (IPSS and IIEF‐5) at 1, 3, 6 and 12 months after RP.…”

Effect of high-dose finasteride combined with transurethral plasmakinetic resection of prostate on prostatespecific antigen and inflammatory factors in patients with benign prostatic hyperplasia

“…The international prostate symptom score (IPSS) [12] and the maximum urinary flow rate of patients in the two groups were measured at 7 days before and after surgery.…”