International study to develop the <scp>WOUND‐Q</scp> patient‐reported outcome measure for all types of chronic wounds

Background: Chronic wounds are a significant burden on healthcare systems due to high costs of care (2%–4% total healthcare cost) and a considerable burden on patient’s quality of life. Patient-reported outcome measures (PROMs) are questionnaires developed to enable patient self-assessments of their outcomes. A gap in knowledge exists because previous reviews on wound-specific PROMs did not evaluate the quality of the development. The main question is which PROM has the best quality development properties and should be used in clinical care and research. Methods: PubMed, Embase, and CINAHL were searched from their inception through December 2021. Studies that included patients aged 18 years or older, with chronic wounds, and who reported using a condition-specific PROM for wounds were extracted. We excluded generic PROMs, comments, guidelines, and editorial letters. The COSMIN-guidelines were used to evaluate the quality of the PROMs. Results: Of the 16,356 articles, a total of 251 articles describing 33 condition-specific PROMs for wounds were used. In total, 17 of 33 (52%) PROMs were developed for specific wound types, and nine of 33 (27%) PROMs were developed for any type of wound. Two of 33 (6%) PROMs were not rated because no development article was available. Only the SCI-QOL (Spinal Cord Injury-QOL) and the WOUND-Q rated “very good” in PROM design. Conclusions: Thirty-three condition-specific PROMs were found. Only the SCI-QOL and the WOUND-Q rated very good in PROM design. The WOUND-Q is the only condition-specific PROM, which can be used in all types of chronic wounds in any anatomic location.

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“…VLU-QoL: Venous Leg Ulcer Quality of Life questionnaire, 62 , 63 30. WOUND-Q, 64 31. Wound-QoL, 65 32.…”

Section: Resultsmentioning

confidence: 99%

“…Two PROMs, the SCI-QOL (Spinal Cord Injury-QOL) and the WOUND-Q, rated very good in PROM design. 53 , 54 , 64 In subscore cognitive interview/pilot test scores, 23 of 33 (70%) studies scored inadequate, eight of 33 (24%) scored doubtful, and two of 33 (6%) were not scored.…”

Section: Resultsmentioning

confidence: 99%

SCI-QOL and WOUND-Q Have the Best Patient-reported Outcome Measure Design: A Systematic Literature Review of PROMs Used in Chronic Wounds

Alphen

Brugge

Haren

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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“…The need for accurate histological grading of wounds based on the different parameters within each phase of wound healing has been emphasized in reviews of the skin wound healing literature [15][16][17]. Despite numerous tools available for the clinical evaluation of wounds in human patients [6,18], to our knowledge this is the first study to statistically standardize and validate a histopathologic scoring system for grading murine skin wounds. The scoring system was based on parameters routinely assessed in literature and was selected to correspond with the different phases of healing.…”

Section: Discussionmentioning

confidence: 99%

“…Since underlying conditions such as age, stress, obesity, and diabetes (DM) are associated with dysfunctional healing responses, the prevalence of chronic wounds are expected to increase considerably in the near future [5]. In addition to placing enormous strain on health care systems, chronic wounds can have debilitating consequences for patients [1,3,5,6].…”

Section: Introductionmentioning

confidence: 99%

Histology Scoring System for Murine Cutaneous Wounds

Vyver

Boodhoo

Frazier³

et al. 2021

Stem Cells and Development

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Monitoring wound progression over time is a critical aspect for studies focused on in-depth molecular analysis or on evaluating the efficacy of potential novel therapies. Histopathological analysis of wound biopsies can provide significant insight into healing dynamics, yet there is no standardized and reproducible scoring system currently available. The purpose of this study was to develop and statistically validate a scoring system based on parameters in each phase of healing that can be easily and accurately assessed using either Hematoxylin & Eosin (H&E) or Masson's Trichrome (MT) staining. These parameters included re-epithelization, epithelial thickness index, keratinization, granulation tissue thickness, remodeling, and the scar elevation index. The initial phase of the study was to (1) optimize and clarify healing parameters to limit investigator bias and variability; (2) compare the consistency of parameters assessed using H&E versus MT staining. During the validation phase of this study, the accuracy and reproducibility of this scoring system was independently iterated upon and validated in four different types of murine skin wound models (Excisional; punch biopsy; pressure ulcers; burn wounds). A total of n = 54 histology sections were randomized, blinded, and assigned to two groups of independent investigators (n = 5 per group) for analysis. The sensitivity of each parameter (ranging between 80% and 95%) is reported with illustrations on the appropriate assessment method using ImageJ software. In the validated scoring system, the lowest score (score:0) is associated with an open/unhealed wound as is evident immediately and within the first day postinjury, whereas the highest score (score:12) is associated with a completely closed and healed wound without excessive scarring. This study defines and describes the minimum recommended criteria for assessing wound healing dynamics using the SPOT skin wound score. The acronym SPOT refers to the academic and scientific institutions that were involved in the development of the scoring system, namely

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“…For example, the HS-QoL was published more recently and has not yet been used in prospective studies. 32,34 The Dermatology Life Quality Index…”

Section: Patient-reported Outcome Measuresmentioning

confidence: 99%

Use of Patient-Reported Outcome Measures in the Surgical Treatment of Hidradenitis Suppurativa: A Systematic Review

et al. 2022

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BACKGROUND Surgery is considered to be the best treatment for recurrent hidradenitis suppurativa (HS). Although it is necessary to assess the effect on health-related quality of life (HR-QoL), patient-reported outcome measures (PROMs) are scarce and heterogeneously used in the literature about the surgical treatment of HS. OBJECTIVE The aim of this study was to provide a review of the complete literature for different PROMs used in the surgical treatment of HS and to assess their methodological qualities. METHODS A systematic literature search of PubMed, Medline, Cochrane, CINAHL, and Embase with an assessment following the COnsensus-based standards for the Selection of health status Measurement INstrument criteria. RESULTS The search identified 218 articles, with the inclusion of 6 studies for analysis. Identified PROMs were as follows: the Dermatology Life Quality Index (DLQI), the Derriford Appearance Scale-24 (DAS-24), and the Work Productivity and Activity Impairment (WPAI). These non-disease-specific PROMs seem to have poor results concerning development and content validation. CONCLUSION The DLQI, WPAI, and DAS-24 are generic PROMs with poor methodological qualities for PROM development and content validation. Hidradenitis suppurativa-specific instruments are not used in available studies because they have been developed recently and, therefore, partially validated. More research is needed to further investigate methodological qualities of HS-specific instruments.

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International study to develop the WOUND‐Q patient‐reported outcome measure for all types of chronic wounds

Cited by 16 publications

References 45 publications

SCI-QOL and WOUND-Q Have the Best Patient-reported Outcome Measure Design: A Systematic Literature Review of PROMs Used in Chronic Wounds

SCI-QOL and WOUND-Q Have the Best Patient-reported Outcome Measure Design: A Systematic Literature Review of PROMs Used in Chronic Wounds

Histology Scoring System for Murine Cutaneous Wounds

Use of Patient-Reported Outcome Measures in the Surgical Treatment of Hidradenitis Suppurativa: A Systematic Review

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