International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors

Systematic Mapping of WNT-FZD Protein Interactions Reveals Functional Selectivity by Distinct WNT-FZD Pairs

“…It also regulates a plethora of processes during embryonic development, such as stem cell proliferation, migration, and differentiation. Dysfunction of WNT-FZD signaling leads to impairment of cell regulatory mechanisms, thereby leading to disease, such as cancer and neurological and bone disorders (1)(2)(3). Despite the physiological relevance of this pathway, little is known about the specificity of the interactions between the 19 members of the WNT family of lipoglycoproteins and their respective FZD cell-surface receptors.…”

Structure du récepteur Smoothened

“…L'homologie faible avec les autres classes de récepteurs couplés aux protéines G (RCPG) a conduit à classifier ces récepteurs dans la classe F des RCPG [14] (➜). Cependant, l'appartenance du récepteur Smo à la famille des RCPG demeurait controversée avant sa cristallisation.…”

Targeting Human Cancer Stem Cells with Monoclonal Antibodies

“…The Frizzled (FZD) family of transmembrane G protein-coupled receptors consists of 10 members (FZD 1-10), which are activated by secreted lipoglycoproteins of the Wnt family [177]. The highly conserved Wnt/FZD signaling pathway has multiple functions in animal development and cell fate determination and polarization [178].…”