International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E<sub>2</sub>Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

Norel, Xavier; Sugimoto, Yukihiko; Özen, Gülsev; Abdelazeem, Heba; Amgoud, Yasmine; Bouhadoun, Amel; Bassiouni, Wesam; Goepp, Marie; Mani, Salma; Manikpurage, Hasanga D.; Senbel, Amira; Longrois, Dan; Heinemann, Ákos; Yao, Chengcan; Clapp, Lucie H.

doi:10.1124/pr.120.019331

Cited by 35 publications

(27 citation statements)

References 845 publications

(1,228 reference statements)

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“…On the other hand, myeloid cell-derived IGF1 also influences the outcomes of muscle regeneration through an autocrine effect, which regulates the transition of infiltrating macrophages from a M1 to a M2 phenotype [ 67 , 68 ]. Prostaglandin E2 (PGE2), another important immunosuppressive factor, can inhibit the proliferation of T cells, reduce the toxic effects of NK cells, and shape the functions and phenotypes of macrophages [ 69 – 71 ]. In addition, PGE2 also acts as a strong mitogen for MuSCs, through binding to the EP4 receptor on their own surface, triggering the intracellular cAMP/phosphor-CREB pathway and activating the proliferation-inducing transcription factor Nurr1 , ultimately robustly augmenting MuSC expansion [ 72 ].…”

Section: Regulation Of Myogenesis By Anti-inflammatory Responsesmentioning

confidence: 99%

Redressing the interactions between stem cells and immune system in tissue regeneration

et al. 2021

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Skeletal muscle has an extraordinary regenerative capacity reflecting the rapid activation and effective differentiation of muscle stem cells (MuSCs). In the course of muscle regeneration, MuSCs are reprogrammed by immune cells. In turn, MuSCs confer immune cells anti-inflammatory properties to resolve inflammation and facilitate tissue repair. Indeed, MuSCs can exert therapeutic effects on various degenerative and inflammatory disorders based on their immunoregulatory ability, including effects primed by interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α). At the molecular level, the tryptophan metabolites, kynurenine or kynurenic acid, produced by indoleamine 2,3-dioxygenase (IDO), augment the expression of TNF-stimulated gene 6 (TSG6) through the activation of the aryl hydrocarbon receptor (AHR). In addition, insulin growth factor 2 (IGF2) produced by MuSCs can endow maturing macrophages oxidative phosphorylation (OXPHOS)-dependent anti-inflammatory functions. Herein, we summarize the current understanding of the immunomodulatory characteristics of MuSCs and the issues related to their potential applications in pathological conditions, including COVID-19.

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Section: Regulation Of Myogenesis By Anti-inflammatory Responsesmentioning

confidence: 99%

Redressing the interactions between stem cells and immune system in tissue regeneration

et al. 2021

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“…Several studies suggested that the mediators released from these adipose tissues can be involved in the pathogenesis of OA 33,34 . Prostanoids are released from adipose tissue and they are involved in pain and inflammation 13,22 . Therefore, we focused on the association between prostanoid levels and local fat pad thickness as well as other clinical parameters in knee OA patients.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies including ours indicated that prostanoids were released from adipose tissue [13][14][15][16][17][18] and there are involved in the pathogenesis of obesity [19][20][21] . Among prostanoids, prostacyclin (PGI2) and thromboxane (TxA2) have opposite actions 22 . Therefore, TxA2/PGI2 ratio reflects the pathological condition 23 .…”

Section: Introductionmentioning

confidence: 99%

Diz osteoartriti bulunan hastalarda sinoviyal sıvılarındaki prostanoid düzeyleri ve ultrasonografik bulgular arasındaki ilişki

Özen¹,

Şen

Çelik³

et al. 2021

Cukurova Medical Journal

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ÖzPurpose. The aim of this study was to investigate the association between prostanoid [thromboxane (TxA2) and prostacyclin (PGI2)] levels in synovial fluid and infrapatellar fat pad (IPFP)/ suprapatellar fat pad (SPFP) thickness as well as other clinical findings in knee steoarthritis (OA) patients. Materials and Methods: 16 patients with knee OA with effusion were included. The average pain levels were evaluated using a Visual Analogue Scale (VAS). The pain, stiffness, and physical functions were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The levels of 6-keto-PGF1α, stable metabolite of PGI2, and TxB2, stable metabolite of TxA2, were measured in synovial fluid using an enzyme immunoassay. Results: 6-keto-PGF1α levels were significantly greater than TxB2 levels in synovial fluid of patients with OA. TxB2 levels and TxB2/6-keto-PGF1α ratio were negatively correlated with SPFP and cartilage thickness, respectively. IPFP thickness was positively correlated with SPFP thickness and effusion volume. WOMAC scores were positively correlated with VAS-activity and VACevening scores. Conclusion:In comparison to 6-keto-PGF1α levels in synovial fluid, TxB2 levels seem to be more associated with ultrasonographic findings in patients with OA. Amaç: Bu çalışmada, diz osteoartriti olan hastaların sinoviyal sıvılarındaki prostanoidlerin [tromboksan (TxA2) ve prostasiklin (PGI2)] düzeyi ile infrapatellar ve suprapatellar yağ yastığı kalınlığı ve diğer klinik parametreler arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya efüzyonlu diz osteoartriti bulunan 16 hasta dahil edilmiştir. Ağrı düzeyleri görsel analog skala (VAS) ile değerlendirilmiştir. Ağrı, sertlik ve fiziksel fonksiyon osteoartrit indeksi (WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index) ile değerlendirilmiştir. PGI2'nin kararlı metaboliti olan 6keto-PGF1α ve TxA2'nin kararlı metaboliti olan TxB2 düzeyleri enzim immunoassay yöntemi ile ölçülmüştür. Bulgular: Sinoviyal sıvıda ölçülen 6-keto-PGF1α düzeyleri TxB2 düzeylerine göre anlamlı derecede yüksek bulunmuştur. TxB2 düzeyleri ile suprapatellar yağ yastığı kalınlığı ve TxB2/6-keto-PGF1α oranı ile kıkırdak kalınlığı arasında negatif korelasyon bulunmaktadır. Infrapatellar yağ yastığı kalınlığı ile suprapatellar yağ yastığı kalınlığı ve efüzyon hacmi arasında pozitif korelasyon bulunmaktadır. WOMAC değerleri ile VAS-aktivite ve VAS-gece skorları arasında pozitif korelasyon bulunmaktadır. Sonuç: 6-keto-PGF1α düzeylerine kıyasla, sinoviyal sıvı TxB2 düzeyleri osteoartritli hastalardaki ultrasonografik bulgular ile daha çok ilişkili bulunmuştur.

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“…However, it should be noted that the addition of COX-2 inhibitor did not signi cantly affect the outcomes of randomized clinical trials of non-small cell lung cancer and colon cancer patients 30,31 . In PC, several in vivo and in vitro studies showed that anti-cancer effects including improvement of prognosis of COX-2 inhibitors were limited [32][33][34][35] . Thus, the chemopreventive and anti-cancer effects of COX-2 inhibitors in PC are still controversial.…”

Section: Discussionmentioning

confidence: 99%

Oral administration of E-type prostanoid (EP) 1 receptor antagonist suppresses carcinogenesis and development of prostate cancer via upregulation of apoptosis in an animal model

Miyata

Masato

Mitsunari

et al. 2021

Preprint

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Prostaglandin E2 plays important roles in carcinogenesis and malignant potential of prostate cancer (PC) by binding to its specific receptors, E-type prostanoid (EP) receptors. However, anti-carcinogenic effects of EP receptor antagonist are not clear. In this study, feed with or without EP1 receptor antagonist were given to a mouse model of prostate cancer. The mice were sacrificed at 10, 15, 30, and 52 weeks of age. Apoptosis was evaluated by immunohistochemical analysis using cleaved caspase-3. The incidence of cancer in the experimental group was significantly lower than that in the control group at 15, 30, and 52 weeks of age. The percentage of poorly differentiated PC cells was significantly lower in the experimental group than in the control group at 30 and 52 weeks of age. The survival period in the experimental group was significantly longer than that in the control group, and the percentage of apoptotic cells in the experimental group was significantly higher than that in the control group at 15, 30, and 52 weeks of age. Thus, an EP1 receptor antagonist delayed PC progression via the upregulation of apoptosis. We suggest that EP1 receptor may be a novel chemopreventive agent for the development of PC.

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International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E₂Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

Cited by 35 publications

References 845 publications

Redressing the interactions between stem cells and immune system in tissue regeneration

Redressing the interactions between stem cells and immune system in tissue regeneration

Diz osteoartriti bulunan hastalarda sinoviyal sıvılarındaki prostanoid düzeyleri ve ultrasonografik bulgular arasındaki ilişki

Oral administration of E-type prostanoid (EP) 1 receptor antagonist suppresses carcinogenesis and development of prostate cancer via upregulation of apoptosis in an animal model

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International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

Cited by 35 publications

References 845 publications

Redressing the interactions between stem cells and immune system in tissue regeneration

Redressing the interactions between stem cells and immune system in tissue regeneration

Diz osteoartriti bulunan hastalarda sinoviyal sıvılarındaki prostanoid düzeyleri ve ultrasonografik bulgular arasındaki ilişki

Oral administration of E-type prostanoid (EP) 1 receptor antagonist suppresses carcinogenesis and development of prostate cancer via upregulation of apoptosis in an animal model

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Product

Resources

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International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E₂Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions