Interneuron Types and Their Circuits in the Basolateral Amygdala

Hájos, Norbert

doi:10.3389/fncir.2021.687257

Cited by 34 publications

(43 citation statements)

References 166 publications

(367 reference statements)

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“…The amygdala, located in the medial temporal lobe of most mammals ( Sah et al, 2003 ), plays an important role in processing information about anxiety-inducing stimuli, and modulates emotional and behavioral responses ( Delgado et al, 2006 ; Sharp, 2017 ). The microcircuit in amygdala relevant for anxious responses includes the basolateral complex (BLA) and the central nucleus (CeA) ( Yang and Wang, 2017 ; Hájos, 2021 ). The BLA, as the main integrated input nucleus into the amygdala, receives processed and multisensory information from different brain regions such as the sensory thalamic and cortical structures as well as the hippocampus, PFC and the locus coeruleus ( McCall et al, 2015 ; Sah, 2017 ; Zhang et al, 2018 ; Pi et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Melanin-concentrating hormone promotes anxiety and intestinal dysfunction via basolateral amygdala in mice

Zhang

et al. 2022

Front. Pharmacol.

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The limbic system plays a pivotal role in stress-induced anxiety and intestinal disorders, but how the functional circuits between nuclei within the limbic system are engaged in the processing is still unclear. In our study, the results of fluorescence gold retrograde tracing and fluorescence immunohistochemistry showed that the melanin-concentrating hormone (MCH) neurons of the lateral hypothalamic area (LHA) projected to the basolateral amygdala (BLA). Both chemogenetic activation of MCH neurons and microinjection of MCH into the BLA induced anxiety disorder in mice, which were reversed by intra-BLA microinjection of MCH receptor 1 (MCHR1) blocker SNAP-94847. In the chronic acute combining stress (CACS) stimulated mice, SNAP94847 administrated in the BLA ameliorated anxiety-like behaviors and improved intestinal dysfunction via reducing intestinal permeability and inflammation. In conclusion, MCHergic circuit from the LHA to the BLA participates in the regulation of anxiety-like behavior in mice, and this neural pathway is related to the intestinal dysfunction in CACS mice by regulating intestinal permeability and inflammation.

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Section: Introductionmentioning

confidence: 99%

Melanin-concentrating hormone promotes anxiety and intestinal dysfunction via basolateral amygdala in mice

Zhang

et al. 2022

Front. Pharmacol.

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“…Among the multiple subnucleus of amygdala, the basolateral amygdala (BLA) is considered the main entry site for receiving and integrating multisensory information from the cortex, thalamus, and other regions [6]. Upon integration, the signal is then transmitted to its downstream brain regions involved in regulating emotional responses [7].…”

Section: Introductionmentioning

confidence: 99%

Connectivity and functional characterization of the mouse contralateral projecting neurons in basolateral amygdala

Zou¹,

Shang²,

Liu³

et al. 2022

Stress and Brain

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Amygdala is widely known as a critical neural hub for modulating negative emotions such as fear and anxiety. Recent studies have shown that the basolateral amygdala (BLA) has reciprocal innervation, which plays an important role in regulating social interaction and associative memory. However, the connectivity pattern and functional role of the contralateral projecting BLA neurons in stress-related anxiety are not fully understood. Here, using the virus tracing strategy, we first characterized the connectivity pattern of the contralateral projecting neurons in BLA. Then, we examined the effect of stress on the functional changes of those specific neuronal populations using a mouse model of inescapable footshock stress. The results showed that the fibers of the contralateral projecting BLA neurons labeled by enhanced green fluorescent protein (EGFP) have no collateral projections to the ipsilateral or contralateral hippocampus. Interestingly, they have some collateral projections to the ipsilateral medial prefrontal cortex. Behavioral results showed that footshock stress increases the anxiety-like behavior in mice; however, the excitatory synaptic transmission and intrinsic excitability of the contralateral projecting BLA neurons measured by whole-cell patch clamp recording did not change after stress exposure. In conclusion, our results indicate that contralateral projecting BLA neurons may not contribute to footshock stress-related anxiety-like behavior.

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“…Inhibitory synapses can be identified by specific inhibitory presynaptic markers, such as the vesicular GABA transporter (VGAT). There are several recent excellent reviews on interneuronal diversity and the reader can find detailed descriptions of their development, molecular profile, connectivity and physiology ( Freund and Buzsáki, 1996 ; Hájos, 2021 ; Lim et al, 2018 ; Tremblay et al, 2016 ). The subpopulations are defined by their differential expression of calcium binding proteins, neuropeptides, neurotransmitter receptors and the target of their axons, which define their structure, connectivity and physiology.…”

Section: The Diverse World Of Inhibitory Neuronsmentioning

confidence: 99%