Interobserver Variability in Ultrasound‐Based Liver Fat Quantification

Şendur, Halit Nahit; Cerit, Mahi Nur; Ibrahimkhanli, Nemat; Şendur, Aylin Billur; Oktar, Suna Özhan

doi:10.1002/jum.16048

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…The method is available as tissue scatter distribution imaging (TSI, Samsung Medison), and the TSI image acquisition process is similar to that of TAI [ 3 ]. According to the preliminary study data, the method is highly reproducible, operator-independent, and easy to learn [ 32 ]. Similar conclusions were reached in related studies, which also identified a good correlation of both parameters with CAP when assessing the presence of LS [ 33 , 34 ].…”

Section: Ultrasound Methods Used For Ls Evaluationmentioning

confidence: 99%

Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area

Hari

2022

Diagnostics

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Liver steatosis is a chronic liver disease that is becoming one of the most important global health problems, due to its direct connection with metabolic syndrome, its significant impact on patients’ socioeconomic status and frailty, and the occurrence of advanced chronic liver disease. In recent years, there has been rapid technological progress in the ultrasound-based diagnostics field that can help us to quantitatively assess liver steatosis, including continuous attenuation parameters in A and B ultrasound modes, backscatter coefficients (e.g., speed of sound) and ultrasound envelope statistic parametric imaging. The methods used in this field are widely available, have favorable time and financial profiles, and are well accepted by patients. Less is known about their reliability in defining the presence and degree of liver steatosis. Numerous study reports have shown the methods’ favorable negative and positive predictive values in comparison with reference investigations (liver biopsy and MRI). Important research has also evaluated the role of these methods in diagnosing and monitoring non-alcoholic fatty liver disease (NAFLD). Since NAFLD is becoming the dominant global cause of liver cirrhosis, and due to the close but complex interplay of liver steatosis with the coexistence of liver fibrosis, knowledge regarding NAFLD’s influence on the progression of liver fibrosis is of crucial importance. Study findings, therefore, indicate the possibility of using these same diagnostic methods to evaluate the impact of NAFLD on the patient’s liver fibrosis progression risk, metabolic risk factors, cardiovascular complications, and the occurrence of hepatocellular carcinoma. The mentioned areas are particularly important in light of the fact that most of the known chronic liver disease etiologies are increasingly intertwined with the simultaneous presence of NAFLD.

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Section: Ultrasound Methods Used For Ls Evaluationmentioning

confidence: 99%

Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area

Hari

2022

Diagnostics

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“…In particular, the Nakagami distribution correlates backscattering to the percentage of liver fat. In our work, Nakagami distribution is calculated by a parameter, tissue scatter distribution imaging (TSI, Samsung Medison), which calculates the concentration and the distribution of the ultrasound scatterers [ 41 , 42 ].…”

Section: Tissue Scatter Distribution Imaging (Tsi Samsung Medison)mentioning

confidence: 99%

Quantitative ultrasound (QUS) in the evaluation of liver steatosis: data reliability in different respiratory phases and body positions

Rocca,

Komici,

Brunese

et al. 2024

Radiol med

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Liver steatosis is the most common chronic liver disease and affects 10–24% of the general population. As the grade of disease can range from fat infiltration to steatohepatitis and cirrhosis, an early diagnosis is needed to set the most appropriate therapy. Innovative noninvasive radiological techniques have been developed through MRI and US. MRI-PDFF is the reference standard, but it is not so widely diffused due to its cost. For this reason, ultrasound tools have been validated to study liver parenchyma. The qualitative assessment of the brightness of liver parenchyma has now been supported by quantitative values of attenuation and scattering to make the analysis objective and reproducible. We aim to demonstrate the reliability of quantitative ultrasound in assessing liver fat and to confirm the inter-operator reliability in different respiratory phases. We enrolled 45 patients examined during normal breathing at rest, peak inspiration, peak expiration, and semi-sitting position. The highest inter-operator agreement in both attenuation and scattering parameters was achieved at peak inspiration and peak expiration, followed by semi-sitting position. In conclusion, this technology also allows to monitor uncompliant patients, as it grants high reliability and reproducibility in different body position and respiratory phases.

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“…However, the sensitivity of ultrasonography is limited when hepatic steatosis content is below a certain threshold [ 59 ]. Traditional ultrasonography uses semi-quantitative ordinal classifications for liver fat, such as mild, moderate, and severe, which exhibit limited inter-observer agreement [ 76 ]. In contrast, contemporary quantitative ultrasound techniques offer enhanced performance using quantitative data derived from acoustic parameters of liver tissue.…”

Section: Introductionmentioning

confidence: 99%