Interocular Symmetry in Macular Choroidal Thickness in Children

Abstract

Objective. To report interocular differences in choroidal thickness in children using spectral domain optical coherence tomography (SD-OCT) and correlate findings with biometric data. Methods. This observational cross-sectional study included 91 (182 eyes) healthy children aged 6 to 17 years with no ocular abnormality except refractive error. After a comprehensive eye exam and axial length measurement, high definition macular scans were performed using SD-OCT. Two observers manually measured the choroidal thickness at the foveal center and at 1500 µm nasally, temporally, inferiorly, and superiorly. Interocular differences were computed; correlations with age, gender, refractive error, and axial length were performed. Results. Mean age was 10.40 ± 3.17 years; mean axial length and refractive error values were similar between fellow eyes. There was excellent correlation between the two observers' measurements. No significant interocular differences were observed at any location. There was only a trend for right eyes to have higher values in all thicknesses, except the superior thickness. Most of the choroidal thickness measurements correlated positively with spherical equivalent but not with axial length, age, or gender. Conclusion. Choroidal thickness measurements in children as performed using SD-OCT revealed a high level of interobserver agreement and consistent interocular symmetry. Values correlated positively with spherical equivalent refraction.

Choroidal and Retinal Thickness in Children With Different Refractive Status Measured by Swept-Source Optical Coherence Tomography

“…This result was consistent with previous reports in both adult and pediatric patients. 5,17,22,24,[27][28][29][30][31][32][33] No statistical correlation between central foveal choroidal thickness and retinal thickness was observed, which is consistent with a previous retrospective adult study. 34 The mean central foveal retinal thickness of the myopic participants in our study was 234 mm, which is very close to the 240 mm mean retinal thickness reported in a former study that was also conducted in Chinese children.…”

Sex differences and subclinical retinal injury in pediatric-onset MS

“…It has recently been reported that healthy boys have larger macular volumes than girls. 19 In our MS cases, we observed that male sex was associated with larger total macular volumes (0.075 mm 3 , 95% CI = 0.008, 0.14, p = 0.028). In our smaller set of control subjects, we observed a similar point estimate for greater volumes in males (0.077 mm 3 , 95% CI = −0.021, 0.17, p = 0.13) although this did not reach statistical significance.…”

“…: volume; GCL: ganglion cell layer; IPL: inner plexiform layer; M/F: male/female. Models for macular metrics with mutual adjustment for the four variables listed: age, history of ON, sex and disease duration. a Macular volumes have been reported to be larger in healthy boys versus girls. 19 …”

Discrepancy in Subfoveal Choroidal Thickness in Healthy Adults with Isometropia

“…1e4 Previous studies have demonstrated interocular symmetry of choroidal thickness, and interocular difference seems to be correlated with interocular difference of axial length in adults 1,2 and children. 3 However, in our clinical setting, interocular differences of choroidal thicknesses are greater in some individuals, although these patients do not seem to have definite anisometropia. Thus, we investigated the interocular discrepancy in subfoveal choroidal thickness in healthy volunteers with isometropia in this study.…”