Interpenetrating Polymer Network Hydrogel Membranes of Karayagum and Sodium Alginate for Control Release of Flutamide Drug

Abstract

Flutamide (FLT) is a potent non-steroidal antiandrogen drug primarily used in palliative treatment of prostate cancer that inhibits androgen uptake and / or nuclear binding of androgen in target tissue. The present study gives, the experimental results on the successful encapsulation of Flutamide drug using Sodium Alginate (SA)/ Karaya gum (KG)) blend hydrogel membranes as controlled release (CR) polymer matrices. The Flutamidecontaining polymer blend hydrogel membranes have been prepared by changing the experimental variables such as KG, SA and drug content by solution casting evaporation method. The membranes were characterized by swelling studies, FTIR, DSC, XRD, and SEM studies. The swelling results indicated that swelling of polymer membranes decrease with the increasing the amounts of Karaya gum. However, no significant variation in swelling was observed with different amounts of flutamide loading. The absence of chemical interactions between active ingredients and polymer was confirmed by FT-IR spectral measurements. Differential scanning calorimeter (DSC) and X-ray diffraction (XRD) studies were performed to understand the crystalline nature of drug after encapsulation into the Hydrogel membranes. Scanning electron microscopy (SEM) was used to study the surface morphology of the hydrogel membranes. The in vitro studies were carried out in phosphate buffer pH 7.4 at 37 o C. The results of controlled release tests showed that the amount of Flutamide release increased with the increasing the amount of SA in the membrane. Moreover, the release rate of drug increased as the amount of drug loaded in the membranes increased. All the results indicated that the prepared membrane was potentially useful in drug delivery systems and the prolonged release rate was observed. Key words:Interpenetrating Polymer Network, Flutamide, Encapsulation, Karaya Gum. INTRODUCTIONIn recent years, biodegradable polymers have attracted attention to be used as biomaterials particularly, for tissue engineering, gene therapy, wound healing and controlled drug delivery systems (Sahoo et al., 2009). The most important advantage of biodegradable polymers is the disappearance of implanted foreign materials from the body as a result of their biodegradation. In general polymers used in biomedical * Corresponding Author E-mail: chowdojirao @ gmail.com applications are poly (lactic acid), poly(glycolic acid) (PGA), poly(e-caprolactone) (PCL), poly(3-hydroxyl butyrate) (PHB), copolymers of polyglycolide, chitosan, alginate and natural gums such as Xanthan Gum, Guar gum (Sahoo et al., 2010; Edulund et al., 2002;Jain Rajeev et al., 2002;Kamath et al., 1993).Different types of drug delivery systems, like microcapsules, microspheres, implants, pallets and hydrogel membranes have been fabricated by using above bio-degradable polymers as drug matrix. Hydrogel membranes play a major role in medical applications, in particular in a number of life saving treatment methods. Membranes are used in drug delivery, artificial organs, tissue regeneration,...

Fabrication and characterization of smart karaya gum/sodium alginate semi-IPN microbeads for controlled release of D-penicillamine drug

“…The percentage of D-PA release was increased by increasing the content of SA in the polymer matrix due to its more hydrophilic nature. As the content of KG increases, the percentage of D-PA release was decreased due to the presence of ester linkages in the KG which increases the hydrophobicity of the matrix, thereby decreasing the release rate of D-PA. 39…”

“…The percentage of D-PA release was increased by increasing the content of SA in the polymer matrix due to its more hydrophilic nature. As the content of KG increases, the percentage of D-PA release was decreased due to the presence of ester linkages in the KG which increases the hydrophobicity of the matrix, thereby decreasing the release rate of D-PA. 39 Effect of drug variation. The effect of drug content on in vitro release profiles was studied at constant polymer content was studied for formulations of SK2 (100 mg), SK8 (150 mg), and SK9(50 mg).…”

Polymeric Based Hydrogel Membranes for Biomedical Applications

“…In 2016, Nagarjuna et al [ 137 ] developed a hydrogel membrane consisting of a mixture of sodium alginate (SA) and Karaya rubber (KG). It was used for testing the sustained release, in physiological conditions obtained by phosphate buffer (pH 7.4 T 37 °C), of flutamide (FLT), a potent nonsteroidal antiandrogenic prostate anticancer drug, which was membrane-loaded.…”