Interplay between biomaterials and the immune system: Challenges and opportunities in regenerative medicine

Salthouse, Daniel; Novakovic, Katarina; Hilkens, Catharien; Ferreira, Ana Marina

doi:10.1016/j.actbio.2022.11.003

Cited by 54 publications

(43 citation statements)

References 98 publications

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“…The appropriate recruitment, differentiation, and activation of the right cell types as well as the progressive resolution of the acute inflammatory phase with time are both necessary for optimal tissue healing and biomaterial integration. Neutrophil persistence and chronic inflammatory signaling can, for example, result in foreign body giant cell recruitment, fibrotic capsule formation, and implant rejection . Several biomaterial characteristics such as host protein adsorption, surface topography and chemistry, mechanical properties, and biodegradability can influence the immune response to a biomaterial.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical Characterization and Immunomodulatory Activity of Polyelectrolyte Multilayer Coatings Incorporating an Exopolysaccharide from Bifidobacterium longum

Bagnol,

Siverino,

Barnier

et al. 2023

Biomacromolecules

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Section: Resultsmentioning

confidence: 99%

Physicochemical Characterization and Immunomodulatory Activity of Polyelectrolyte Multilayer Coatings Incorporating an Exopolysaccharide from Bifidobacterium longum

Bagnol,

Siverino,

Barnier

et al. 2023

Biomacromolecules

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“…At the same time, polyacrylamide, poly(vinyl pyrrolidone), poly(methacrylic acid), as well as PVA can also be used as a material. The mechanism of biocompatibility increase is associated with an improvement in the hydrophilicity of the surface, i.e., a preventive decrease in the absorption of proteins on the surface, the blood coagulation, and the immune response [ 162 , 163 ]. It is shown that such modification is relevant primarily for short-term blood-contacting applications; however, presumably, PVA might be the most promising polymer for long-term blood-contacting PHV valves, taking into account the problems of cycle resistance.…”

Section: Novel Polymers: Materials Synthesis and Propertiesmentioning

confidence: 99%

Polymeric Heart Valves Will Displace Mechanical and Tissue Heart Valves: A New Era for the Medical Devices

Резвова

Klyshnikov

Грицкевич³

et al. 2023

IJMS

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The development of a novel artificial heart valve with outstanding durability and safety has remained a challenge since the first mechanical heart valve entered the market 65 years ago. Recent progress in high-molecular compounds opened new horizons in overcoming major drawbacks of mechanical and tissue heart valves (dysfunction and failure, tissue degradation, calcification, high immunogenic potential, and high risk of thrombosis), providing new insights into the development of an ideal artificial heart valve. Polymeric heart valves can best mimic the tissue-level mechanical behavior of the native valves. This review summarizes the evolution of polymeric heart valves and the state-of-the-art approaches to their development, fabrication, and manufacturing. The review discusses the biocompatibility and durability testing of previously investigated polymeric materials and presents the most recent developments, including the first human clinical trials of LifePolymer. New promising functional polymers, nanocomposite biomaterials, and valve designs are discussed in terms of their potential application in the development of an ideal polymeric heart valve. The superiority and inferiority of nanocomposite and hybrid materials to non-modified polymers are reported. The review proposes several concepts potentially suitable to address the above-mentioned challenges arising in the R&D of polymeric heart valves from the properties, structure, and surface of polymeric materials. Additive manufacturing, nanotechnology, anisotropy control, machine learning, and advanced modeling tools have given the green light to set new directions for polymeric heart valves.

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“…Innate immune cells recognize the lipid A portion of endotoxin through Toll-like receptor-4 (TLR4), which initiates downstream signalling leading to proinflammatory cytokine release, resulting in activation of potent immune responses [ 20 ]. The host immune system can detect and elicit potent proinflammatory responses in response to extremely small concentrations of endotoxin [ 21 ]; for example, monocytes and dendritic cells are shown to be activated by endotoxin concentrations as low as 0.01 ng/mL (0.05 EU/mL) [ 15 ] and 0.02 ng/mL (0.1 EU/mL) [ 22 ], respectively. The FDA have therefore enforced strict regulations on endotoxin levels in medical devices (limit of 0.5 EU/mL [ 23 ]), with devices continually being recalled due to their endotoxin levels exceeding the limit [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Endotoxin contamination is a particular concern for chitosan as the cationic nature of the polymer predisposes its interaction with the negatively charged phosphate groups in LPS ( Figure 1 ) [ 27 ]. Despite the continuous increase in the number of scientific publications related to chitosan [ 28 ], the purity levels, and in particular endotoxin contamination, are seldom acknowledged [ 21 , 29 ]. Chitosan is renowned for its potent immunostimulatory ability [ 30 , 31 , 32 ], and has been reported to elicit both pro- and anti-inflammatory responses [ 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Effective Endotoxin Removal from Chitosan That Preserves Chemical Structure and Improves Compatibility with Immune Cells

et al. 2023

Self Cite

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Chitosan is one of the most researched biopolymers for healthcare applications, however, being a naturally derived polymer, it is susceptible to endotoxin contamination, which elicits pro-inflammatory responses, skewing chitosan’s performance and leading to inaccurate conclusions. It is therefore critical that endotoxins are quantified and removed for in vivo use. Here, heat and mild NaOH treatment are investigated as facile endotoxin removal methods from chitosan. Both treatments effectively removed endotoxin to below the FDA limit for medical devices (<0.5 EU/mL). However, in co-culture with peripheral blood mononuclear cells (PBMCs), only NaOH-treated chitosan prevented TNF-α production. While endotoxin removal is the principal task, the preservation of chitosan’s structure is vital for the synthesis and lysozyme degradation of chitosan-based hydrogels. The chemical properties of NaOH-treated chitosan (by FTIR-ATR) were significantly similar to its native composition, whereas the heat-treated chitosan evidenced macroscopic chemical and physical changes associated with the Maillard reaction, deeming this treatment unsuitable for further applications. Degradation studies conducted with lysozyme demonstrated that the degradation rates of native and NaOH-treated chitosan-genipin hydrogels were similar. In vitro co-culture studies showed that NaOH hydrogels did not negatively affect the cell viability of monocyte-derived dendritic cells (moDCs), nor induce phenotypical maturation or pro-inflammatory cytokine release.

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Interplay between biomaterials and the immune system: Challenges and opportunities in regenerative medicine

Cited by 54 publications

References 98 publications

Physicochemical Characterization and Immunomodulatory Activity of Polyelectrolyte Multilayer Coatings Incorporating an Exopolysaccharide from Bifidobacterium longum

Physicochemical Characterization and Immunomodulatory Activity of Polyelectrolyte Multilayer Coatings Incorporating an Exopolysaccharide from Bifidobacterium longum

Polymeric Heart Valves Will Displace Mechanical and Tissue Heart Valves: A New Era for the Medical Devices

Effective Endotoxin Removal from Chitosan That Preserves Chemical Structure and Improves Compatibility with Immune Cells

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