Interplay between cellular metabolism and DNA viruses

Zandi, Milad; Shokri, Somayeh; Mahmoudvand, Shahab; Adli, Ahmad Hosseinzadeh; Mohammadi, Ramin; Haddadi, Azita

doi:10.1002/jmv.28018

Cited by 13 publications

(11 citation statements)

References 149 publications

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“…At 24 h.p.i., tricarboxylic acid cycle (TCA cycle), fatty acid metabolism, and biosynthesis of cofactors were significantly enriched ( Figure 4B ). Regular metabolic alternations were activated and dysregulated for available energetic demands of virus production ( Zandi et al, 2022 ). At 36 h.p.i., regulation of actin cytoskeleton was enriched and distinguished from other time points of infection ( Figure 4C ).…”

Section: Resultsmentioning

confidence: 99%

Temporal proteomic profiling reveals functional pathways in vaccinia virus-induced cell migration

Liu

Chen

et al. 2023

Front. Microbiol.

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IntroductionViral diseases have always been intricate and persistent issues throughout the world and there is a lack of holistic discoveries regarding the molecular dysregulations of virus-host interactions. The temporal proteomics strategy can identify various differentially expressed proteins and offer collaborated interaction networks under pathological conditions.MethodHerein, temporal proteomics at various hours post infection of Vero cells were launched to uncover molecular alternations during vaccinia virus (VACV)-induced cell migration. Different stages of infection were included to differentiate gene ontologies and critical pathways at specific time points of infection via bioinformatics.ResultsBioinformatic results showed functional and distinct ontologies and pathways at different stages of virus infection. The enrichment of interaction networks and pathways verified the significances of the regulation of actin cytoskeleton and lamellipodia during VACV-induced fast cell motility.DiscussionThe current results offer a systematic proteomic profiling of molecular dysregulations at different stages of VACV infection and potential biomedical targets for treating viral diseases.

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Section: Resultsmentioning

confidence: 99%

Temporal proteomic profiling reveals functional pathways in vaccinia virus-induced cell migration

Liu

Chen

et al. 2023

Front. Microbiol.

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“…That virus infections, as mentioned, including COVID-19 are influenced by the circadian clock (Ray and Reddy 2020 ; Zandi et al 2022 ; Zandi 2022 ). That the circadian clock effects on viruses may be a general phenomenon, supports the notion that mpox pathophysiology is likely under the control of the clock as well, even though there is as yet no direct evidence.…”

Section: Circadian Clock and Viral Infectionsmentioning

confidence: 99%

Monkeypox virus replication underlying circadian rhythm networks

et al. 2023

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The mammalian brain has an endogenous central circadian clock that regulates central and peripheral cellular activities. At the molecular level, this day-night cycle induces the expression of upstream and downstream transcription factors that influence the immune system and the severity of viral infections over time. In addition, there are also circadian effects on host tolerance pathways. This stimulates adaptation to normal changes in environmental conditions and requirements (including light and food). These rhythms influence the pharmacokinetics and efficacy of therapeutic drugs and vaccines. The importance of circadian systems in regulating viral infections and the host response to viruses is currently of great importance for clinical management. With the knowledge gained from the COVID-19 pandemic, it is important to address any outbreak of viral infection that could become endemic and to quickly focus research on any knowledge gaps. For example, responses to booster vaccination COVID-19 may have different time-dependent patterns during circadian cycles. There may be a link between reactivation of latently infected viruses and regulation of circadian rhythms. In addition, mammals may show different seasonal antiviral responses in winter and summer. This article discusses the importance of the host circadian clock during monkeypox infection and immune system interactions.

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“…There is also evidence suggesting that factors like inflammation, ageing, and viral infections can contribute to the incidence of AD 77 . However, there is evidence suggesting that factors such as inflammation, 79 ageing, 79,80 and viral infections 81 can also contribute to the incidence of AD. Neuro‐toxicity, immune response, and inflammation caused by CMV may directly and/or indirectly lead to lesser amyloid beta peptides (A β ) such as Aβ42/Aβ40 in plasma 82…”

Section: Data Extractionmentioning

confidence: 99%

Association between cytomegalovirus infection and neurological disorders: A systematic review

Sanami,

Shamsabadi,

Dayhimi

et al. 2024

Reviews in Medical Virology

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Cytomegalovirus (CMV) belongs to the Herpesviridae family and is also known as human herpesvirus type 5. It is a common virus that usually doesn't cause any symptoms in healthy individuals. However, once infected, the virus remains in the host's body for life and can reactivate when the host's immune system weakens. This virus has been linked to several neurological disorders, including Alzheimer's disease, Parkinson's disease, Autism spectrum disorder, Huntington's disease (HD), ataxia, Bell's palsy (BP), and brain tumours, which can cause a wide range of symptoms and challenges for those affected. CMV may influence inflammation, contribute to brain tissue damage, and elevate the risk of moderate‐to‐severe dementia. Multiple studies suggest a potential association between CMV and ataxia in various conditions, including Guillain‐Barré syndrome, chronic inflammatory demyelinating polyneuropathy, acute cerebellitis, etc. On the other hand, the evidence regarding CMV involvement in BP is conflicting, and also early indications of a link between CMV and HD were challenged by subsequent research disproving CMV's presence. This systematic review aims to comprehensively investigate any link between the pathogenesis of CMV and its potential role in neurological disorders and follows the preferred reporting items for systematic review and meta‐analysis checklist. Despite significant research into the potential links between CMV infection and various neurological disorders, the direct cause‐effect relationship is not fully understood and several gaps in knowledge persist. Therefore, continued research is necessary to gain a better understanding of the role of CMV in neurological disorders and potential treatment avenues.

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Interplay between cellular metabolism and DNA viruses

Cited by 13 publications

References 149 publications

Temporal proteomic profiling reveals functional pathways in vaccinia virus-induced cell migration

Temporal proteomic profiling reveals functional pathways in vaccinia virus-induced cell migration

Monkeypox virus replication underlying circadian rhythm networks

Association between cytomegalovirus infection and neurological disorders: A systematic review

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