Interplay between circular RNA, microRNA, and human diseases

Kour, Bimaljeet; Gupta, Suruchi; Singh, Ravail; Sophiarani, Yengkhom; Paul, Prosenjit

doi:10.1007/s00438-022-01856-8

Cited by 10 publications

(4 citation statements)

References 111 publications

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“…Circular RNAs (circRNAs) are endogenous non-coding single stranded RNAs present in all eukaryotic cells (74), and are characterized by a covalently closed loop structure without a 5' terminal cap and a 3' terminal poly (A) tail (75). CircRNAs are grouped into intronic RNAs (ciRNAs), exonic circRNAs (ecircRNAs) and exon-intron circRNAs (elciRNAs) (76), displaying critical biological roles through playing as transcriptional regulators, ceRNA or miRNA sponges and protein templates (Figure 3) (77). Importantly, several studies have showed that the expression levels of circRNAs are dysregulated during M. tuberculosis infection (Table 2).…”

Section: The Biogenesis and Roles Of Circrnasmentioning

confidence: 99%

Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection

Wang,

Yao,

Qian

et al. 2023

Front. Immunol.

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Exosomes as double-membrane vesicles contain various contents of lipids, proteins, mRNAs and non-coding RNAs, and involve in multiple physiological processes, for instance intercellular communication and immunomodulation. Currently, numerous studies found that the components of exosomal proteins, nucleic acids or lipids released from host cells are altered following infection with Mycobacterium tuberculosis. Exosomal contents provide excellent biomarkers for the auxiliary diagnosis, efficacy evaluation, and prognosis of tuberculosis. This study aimed to review the current literatures detailing the functions of exosomes in the procedure of M. tuberculosis infection, and determine the potential values of exosomes as biomarkers to assist in the diagnosis and monitoring of tuberculosis.

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Section: The Biogenesis and Roles Of Circrnasmentioning

confidence: 99%

Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection

Wang,

Yao,

Qian

et al. 2023

Front. Immunol.

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“…MicroRNA (miRNA) is an endogenous non-coding RNA of about 22 nucleotides, which can bind to the 3′UTR (untranslated region) of target mRNA in the post-transcriptional horizontal direction, which plays an important role in the occurrence and development of tumors [ 6 , 7 ]. The process of miRNA processing and maturation has undergone a spatial transition from the nucleus to the cytoplasm, and the whole process is coordinated by a variety of enzymes and accessory proteins to perform multi-level regulation and multi-step precise reactions [ 8 , 9 ]. However, the role of miRNAs in CCA has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic silencing of miR-125a-3p promotes the progress of human cholangiocarcinoma via increasing CAC1 expression

Guo,

Wang,

Tian

et al. 2024

Heliyon

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“…Recently, increasing evidence has shown that the interaction between miRNAs and circRNAs plays a vital role in the pathogenesis of many human diseases ( 7 ), especially osteoarthritis (OA) ( 8 , 9 ). CircRNA and miRNAs are strongly related to extracellular matrix (ECM) metabolism and inflammation in OA.…”

Section: Introductionmentioning

confidence: 99%

Identification and comprehensive analysis of circRNA–miRNA–mRNA regulatory networks in osteoarthritis

et al. 2023

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Osteoarthritis (OA) is a common orthopedic degenerative disease, leading to high disability in activities of daily living. There remains an urgent need to identify the underlying mechanisms and identify new therapeutic targets in OA diagnosis and treatment. Circular RNAs (circRNAs) play a role in the development of multiple diseases. Many studies have reported that circRNAs regulate microRNAs (miRNAs) through an endogenous competitive mechanism. However, it remains unclear if an interplay between circRNAs, miRNAs, and target genes plays a deeper regulatory role in OA. Four datasets were downloaded from the GEO database, and differentially expressed circRNAs (DECs), differentially expressed miRNAs (DEMs), and differentially expressed genes (DEGs) were identified. Functional annotation and pathway enrichment analysis of DEGs and DECs were carried out to determine the main associated mechanism in OA. A protein–protein network (PPI) was constructed to analyze the function of, and to screen out, hub DEGs in OA. Based on the artificial intelligence prediction of protein crystal structures of two hub DEGs, TOP2A and PLK1, digitoxin and oxytetracycline were found to have the strongest affinity, respectively, with molecular docking. Subsequently, overlapping DEMs and miRNAs targeted by DECs obtained target DEMs (DETMs). Intersection of DEGs and genes targeted by DEMs obtained target DEGs (DETGs). Thus, a circRNA–miRNA–mRNA regulatory network was constructed from 16 circRNAs, 32 miRNAs, and 97 mRNAs. Three hub DECs have the largest number of regulated miRNAs and were verified through in vitro experiments. In addition, the expression level of 16 DECs was validated by RT-PCR. In conclusion, we constructed a circRNA–miRNA–mRNA regulatory network in OA and three new hub DECs, hsa_circ_0027914, hsa_circ_0101125, and hsa_circ_0102564, were identified as novel biomarkers for OA.

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Interplay between circular RNA, microRNA, and human diseases

Cited by 10 publications

References 111 publications

Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection

Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection

Epigenetic silencing of miR-125a-3p promotes the progress of human cholangiocarcinoma via increasing CAC1 expression

Identification and comprehensive analysis of circRNA–miRNA–mRNA regulatory networks in osteoarthritis

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