Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases

Bhattacharya, Sulagna; Agarwal, Sakshi; Shrimali, Nishith M; Guchhait, Prasenjit

doi:10.1016/j.mam.2021.101000

Cited by 17 publications

(13 citation statements)

References 214 publications

(205 reference statements)

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“…Energy and metabolites are required for cell survival. SARS-CoV-2 infections lead to a hypoxic microenvironment ( Bhattacharya et al, 2021 ). This process is akin to the tumor microenvironment (TME) that the feature of TME is hypoxic.…”

Section: Discussionmentioning

confidence: 99%

Altered Lipid Profile in COVID-19 Patients and Metabolic Reprogramming

et al. 2022

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BackgroundCoronavirus disease 2019 (COVID-19) is a global pandemic. Previous studies have reported dyslipidemia in patients with COVID-19. Herein, we conducted a retrospective study and a bioinformatics analysis to evaluate the essential data of the lipid profile as well as the possible mechanism in patients with COVID-19.MethodsFirst of all, the retrospective study included three cohorts: patients with COVID-19, a healthy population, and patients with chronic obstructive pulmonary disease (COPD). For each subject, serum lipid profiles in the biochemical data were compared, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Furthermore, bioinformatics analyses were performed for exploring the biological or immunological mechanisms.ResultsIn line with the biochemical data of the three cohorts, the statistical result displayed that patients with COVID-19 were more likely to have lower levels of TC and HDL-C as compared with healthy individuals. The differential proteins associated with COVID-19 are involved in the lipid pathway and can target and regulate cytokines and immune cells. Additionally, a heatmap revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections were possibly involved in lipid metabolic reprogramming. The viral proteins, such as spike (S) and non-structural protein 2 (Nsp2) of SARS-CoV-2, may be involved in metabolic reprogramming.ConclusionThe metabolic reprogramming after SARS-CoV-2 infections is probably associated with the immune and clinical phenotype of patients. Hence, metabolic reprogramming may be targeted for developing antivirals against COVID-19.

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Section: Discussionmentioning

confidence: 99%

Altered Lipid Profile in COVID-19 Patients and Metabolic Reprogramming

et al. 2022

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“…Monocytopenia has also been observed in mouse models of hypoxic acute lung injury, which leads to a reduction in monocyte-derived macrophages and enhanced neutrophil-mediated inflammation in the lungs [ 34 ]. In the context of respiratory viral diseases, such as influenza and COVID-19 patients, researchers have found that patients with these lower respiratory viral infections often develop hypoxemia, primarily because crosstalk between lung inflammation and a hypoxic microenvironment may impair pulmonary ventilation [ 35 ]. Hypoxia may also promote tissue inflammation–fibrosis [ 36 ].…”

Section: The Implications Of Hypoxiamentioning

confidence: 99%

Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies

Wei

Giunta²,

Xia

2022

IJMS

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As the global aging process continues to lengthen, aging-related diseases (e.g., chronic obstructive pulmonary disease (COPD), heart failure) continue to plague the elderly population. Aging is a complex biological process involving multiple tissues and organs and is involved in the development and progression of multiple aging-related diseases. At the same time, some of these aging-related diseases are often accompanied by hypoxia, chronic inflammation, oxidative stress, and the increased secretion of the senescence-associated secretory phenotype (SASP). Hypoxia seems to play an important role in the process of inflammation and aging, but is often neglected in advanced clinical research studies. Therefore, we have attempted to elucidate the role played by different degrees and types of hypoxia in aging and aging-related diseases and their possible pathways, and propose rational treatment options based on such mechanisms for reference.

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“…However, the natural host immunity and the outcomes of SARS-CoV-2 infection vary with health status; age; and the presence of commodities [ 13 ]. If the host immune response in fighting against SARS-CoV-2 infection, including innate immune signalling activation and adaptive immune components, fails to clear the virus, the patient then enters a severe stage of disease with an acute onset of bilateral infiltrates, severe hypoxaemia, and fluid overload [ 14 ]. Thus, we focused mainly on how the trinity of COVID-19 components, including viral infection, immunity, and the inflammatory immunopathogenesis, interact with one another ( Figure 1 ).…”

Section: Covid-19: a Combat Between Sars-cov-2 Infection And Natural ...mentioning

confidence: 99%

COVID-19: imbalanced cell-mediated immune response drives to immunopathology

Wang

Qiu

et al. 2022

Emerging Microbes & Infections

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an imminent threat to humanity. SARS-CoV-2 invades host cells, causing a failure of host immune recognition. Instead of an effective antiviral immunological response after SARS-CoV-2 invasion, the cascading pathological syndrome of COVID-19, especially in severe disease, is exacerbated by an overt inflammatory response and the suppression of SARS-CoV-2–specific immune responses. As is known, excessive inflammation leads to pathophysiological changes in virus-infected tissues or organs, manifested by imbalanced immune responses, cytokine storm, and aggressive neutrophil activation, ultimately leading to lung damage, such as alveolar damage, endotheliitis, and fluid overload. However, the triggers and consequences of a disruption to immune system homeostasis and the underlying mechanisms of uncontrolled immunopathology following viral infection remain unclear. Here, we review the dynamic and systemic immune progression from an imbalance in cell-mediated immune responses to COVID-19 lung injury. Our understanding of key mechanisms involved in pathogenesis is critical for the development of therapeutic agents and to optimize therapeutic strategies.

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Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases

Cited by 17 publications

References 214 publications

Altered Lipid Profile in COVID-19 Patients and Metabolic Reprogramming

Altered Lipid Profile in COVID-19 Patients and Metabolic Reprogramming

Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies

COVID-19: imbalanced cell-mediated immune response drives to immunopathology

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