Interplay Between Oxidative Stress, Cyclooxygenases, and Prostanoids in Cardiovascular Diseases

Zhao, Sha; Cheng, Chak Kwong; Zhang, Chenglin; Huang, Yü

doi:10.1089/ars.2020.8105

Cited by 47 publications

(51 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Novel drugs targeting oxidative stress, COX-2 and prostanoids against common cardiovascular diseases have been evaluated in recent years. Experiments on animal models have demonstrated that selenium decreases oxidative stress and COX activity, downregulating the leukotriene pathway in diabetic cardiac hypertrophy [ 120 ].…”

Section: Cardiovascular Diseasementioning

confidence: 99%

The Role of Selenium in Pathologies: An Updated Review

2022

View full text Add to dashboard Cite

Selenium is an essential microelement required for a number of biological functions. Selenium—and more specifically the amino acid selenocysteine—is present in at least 25 human selenoproteins involved in a wide variety of essential biological functions, ranging from the regulation of reactive oxygen species (ROS) concentration to the biosynthesis of hormones. These processes also play a central role in preventing and modulating the clinical outcome of several diseases, including cancer, diabetes, Alzheimer’s disease, mental disorders, cardiovascular disorders, fertility impairments, inflammation, and infections (including SARS-CoV-2). Over the past years, a number of studies focusing on the relationship between selenium and such pathologies have been reported. Generally, an adequate selenium nutritional state—and in some cases selenium supplementation—have been related to improved prognostic outcome and reduced risk of developing several diseases. On the other hand, supra-nutritional levels might have adverse effects. The results of recent studies focusing on these topics are summarized and discussed in this review, with particular emphasis on advances achieved in the last decade.

show abstract

Section: Cardiovascular Diseasementioning

confidence: 99%

The Role of Selenium in Pathologies: An Updated Review

2022

View full text Add to dashboard Cite

show abstract

“…Aside from NO, EC function is dependent on the action of prostanoids—products of arachidonate metabolism via the action of cyclooxygenases (COX) [ 29 ]. Several types of prostanoids exist including: prostaglandin D2 (PGD 2 ), prostaglandin I2 (PG I2 ), prostaglandins F2α (PGF 2α ), prostaglandin E2 (PGE 2 ), and thromboxane A2 (TXA 2 ).…”

Section: Formation Of Rosmentioning

confidence: 99%

“…Several types of prostanoids exist including: prostaglandin D2 (PGD 2 ), prostaglandin I2 (PG I2 ), prostaglandins F2α (PGF 2α ), prostaglandin E2 (PGE 2 ), and thromboxane A2 (TXA 2 ). Prostaglandin H2 (PGH 2 ) is an important intermediary step in their synthesis and is converted into specific prostanoids by various prostanoid synthases [ 29 ]. PGE 2 and PG I2 act as vasodilators whilst TXA 2 and PGF 2α induce vasoconstriction [ 29 ].…”

Section: Formation Of Rosmentioning

confidence: 99%

“…Prostaglandin H2 (PGH 2 ) is an important intermediary step in their synthesis and is converted into specific prostanoids by various prostanoid synthases [ 29 ]. PGE 2 and PG I2 act as vasodilators whilst TXA 2 and PGF 2α induce vasoconstriction [ 29 ]. PGD 2 has variable effects on vascular tone depending on site and concentration [ 30 ].…”

Section: Formation Of Rosmentioning

confidence: 99%

See 1 more Smart Citation

Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Glucose Homeostasis and Diabetes-Related Endothelial Cell Dysfunction

Brown

Bridge

Kearney

2021

Cells

View full text Add to dashboard Cite

Oxidative stress within the vascular endothelium, due to excess generation of reactive oxygen species (ROS), is thought to be fundamental to the initiation and progression of the cardiovascular complications of type 2 diabetes mellitus. The term ROS encompasses a variety of chemical species including superoxide anion (O2•-), hydroxyl radical (OH-) and hydrogen peroxide (H2O2). While constitutive generation of low concentrations of ROS are indispensable for normal cellular function, excess O2•- can result in irreversible tissue damage. Excess ROS generation is catalysed by xanthine oxidase, uncoupled nitric oxide synthases, the mitochondrial electron transport chain and the nicotinamide adenosine dinucleotide phosphate (NADPH) oxidases. Amongst enzymatic sources of O2•- the Nox2 isoform of NADPH oxidase is thought to be critical to the oxidative stress found in type 2 diabetes mellitus. In contrast, the transcriptionally regulated Nox4 isoform, which generates H2O2, may fulfil a protective role and contribute to normal glucose homeostasis. This review describes the key roles of Nox2 and Nox4, as well as Nox1 and Nox5, in glucose homeostasis, endothelial function and oxidative stress, with a key focus on how they are regulated in health, and dysregulated in type 2 diabetes mellitus.

show abstract

“…In the kidney vasculature, EP2 and EP4 stimulation result in vasodilation, whereas EP1 and EP3 stimulation result in vasoconstriction [ 253 ]. Cardiomyocyte-specific deletion of the EP4 exacerbates the decline in cardiac function after myocardial infarction [ 232 , 264 ]. These observations raise the possibility that, despite results in healthy volunteers, inhibition of mPGES-1 in male patients with hyperlipidemia may predispose them to an exaggerated BP response to an HSD [ 265 ].…”

Section: Lipid Metabolitesmentioning

confidence: 99%

Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases

Strassheim

Sullivan

Irwin

et al. 2021

Cells

View full text Add to dashboard Cite

G protein-coupled receptors (GPCRs) have originally been described as a family of receptors activated by hormones, neurotransmitters, and other mediators. However, in recent years GPCRs have shown to bind endogenous metabolites, which serve functions other than as signaling mediators. These receptors respond to fatty acids, mono- and disaccharides, amino acids, or various intermediates and products of metabolism, including ketone bodies, lactate, succinate, or bile acids. Given that many of these metabolic processes are dysregulated under pathological conditions, including diabetes, dyslipidemia, and obesity, receptors of endogenous metabolites have also been recognized as potential drug targets to prevent and/or treat metabolic and cardiovascular diseases. This review describes G protein-coupled receptors activated by endogenous metabolites and summarizes their physiological, pathophysiological, and potential pharmacological roles.

show abstract

Interplay Between Oxidative Stress, Cyclooxygenases, and Prostanoids in Cardiovascular Diseases

Cited by 47 publications

References 136 publications

The Role of Selenium in Pathologies: An Updated Review

The Role of Selenium in Pathologies: An Updated Review

Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Glucose Homeostasis and Diabetes-Related Endothelial Cell Dysfunction

Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases

Contact Info

Product

Resources

About