Interplay Between Parameters of the Haemostatic System and Urine Formation in Rats Under Experimental Mercury Intoxication. Preventive Options

Abstract

We have explored the effects of melatonin on the interplay between parameters of the haemostatic system and the disruption in basic processes of urine formation under chronic sublimate intoxication. The prophylactic administration of melatonin was performed at a dose of 5 mg/kg along with the intragastric administration of mercury chloride at a dose of 0.5 mg/kg for two months. The use of melatonin helped reduce the Impairment in vascular-platelet and coagulation haemostasis and in the activity of the anticoagulant and fibrinolytic systems, and contributed to the reduction in thrombinaemia. Observed changes correlated with the restoration of urine formation and lipid peroxidation processes and of the activity of antioxidant blood enzymes. The results of the study suggest that melatonin can be recommended for further studies aimed at developing tools for correcting haemostasis associated with exposure to heavy metal compounds.