Interplay between the Pan-Tumor Suppressor miR-939-5p and the oncogenic lncRNA-HEIH dually curbs Hydrogen Sulphide and Nitric Oxide production in breast cancer cells

Nafea, Heba; Youness, R.A.; Abou-Aisha, Khaled

doi:10.1016/s0959-8049(20)30714-0

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have shown that human breast cancer tissues and cells lines (MDA-MB-468, MCF-7, and Hs578T) reveal the marked overexpression of CBS, CSE, and 3MST compared to normal breast cells [ 31 , 132 , 180 ]. Recently, our research group has highlighted the potential regulation of CBS and CSE in breast cancer cell lines by miR-4317 [ 31 ] and miR-939-5p [ 181 , 182 ]. It is worth mentioning that, recently, miR-548 and miR-193 have been found by our research group to simultaneously target the three synthesizing enzymes in breast cancer: CBS, CSE and 3MST ( Table 2 ) [ 132 , 183 ].…”

Section: Role Of H 2 S In Oncological Disorders An...mentioning

confidence: 99%

Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review

Youness,

Habashy,

Khater

et al. 2024

ncRNA

View full text Add to dashboard Cite

Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a “Maestro” role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possible therapeutic targets. Although a significant amount of work has been conducted on the role of nitric oxide (NO) and carbon monoxide (CO) and their inter-relationship in the field of oncology, research about hydrogen sulfide (H2S) remains in its infancy. Recently, non-coding RNAs (ncRNAs) have been reported to play a dominating role in the regulation of the endogenous machinery system of H2S in several pathological contexts. A growing list of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are leading the way as upstream regulators for H2S biosynthesis in different mammalian cells during the development and progression of human diseases; therefore, their targeting can be of great therapeutic benefit. In the current review, the authors shed the light onto the biosynthetic pathways of H2S and their regulation by miRNAs and lncRNAs in various oncological and non-oncological disorders.

show abstract