Interpretation and Considerations in the Mendelian Randomization Study on Chronic Pain, Analgesics, and Cognitive Status

In Response

“…Once again, we appreciate the comments and suggestions provided by Zhang et al, 1 and we agree that the research on the topic of chronic pain and cognitive function would shed new light on management of the cognitive disorders and chronic pain.…”

“…We appreciate the comments provided by Zhang et al 1 on our study. 2 In their comments, they highlighted the possibility of confounding factors, such as body mass index (BMI) and lifestyle, contributing to the inconsistent findings between our Mendelian randomization (MR) analyses and the observational studies on site-specific chronic pain in dementia.…”

“…We thank Zhang et al 1 for their suggestion regarding multivariable MR (MVMR) for analyzing the relationships among chronic pain, analgesics, and cognitive status. It is true that MVMR allows for the assessment of multiple exposures on a single outcome.…”